PECS II vs SPSIP nerve blocks for pain after mastectomy
Official title: Comparison of the Effects of Pectoral Nerve Block and Serratus Posterior Superior Intercostal Plane Block on Acute and Persistent Postoperative Pain After Mastectomy: A Prospective, Double-Blind, Randomized Controlled Trial
Run by Bursa City Hospital · NCT07929090 · Data updated 2026-11-12
This study tests whether two ultrasound-guided nerve blocks (PECS II and SPSIP) differ in how much opioid patients need after mastectomy.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 85 Years |
| Sex | Women only |
| Enrollment | 78 (estimated) |
| Sponsor | Bursa City Hospital Government |
| Locations | 1 site (Nilufer, Bursa) |
| Status | Recruiting |
| Started | November 1, 2026 |
| Main results expected | June 15, 2027 |
| Study ends | June 15, 2027 |
| Registry record updated | November 10, 2026 |
| Trial ID | NCT07929090 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–85 undergoing elective mastectomy for breast cancer without contraindications to the blocks or planned bilateral surgery.
✕Probably not a fit
Patients who do not respond to a single-block technique or who have characteristics limiting block effectiveness may see no benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults undergoing elective mastectomy are randomized to receive either a PECS II block or an SPSIP block before anesthesia, with standard postoperative pain control including tramadol via patient-controlled device. The trial measures opioid consumption and pain scores at multiple time points in the first 24 hours after surgery, along with recovery quality and need for additional analgesia. Outcomes are assessed by a blinded anesthesiologist to reduce bias. The study aims to determine which block provides better postoperative pain control with fewer side effects.
Why it matters
Potential benefit: If successful, the more effective block could reduce opioid use and improve recovery after mastectomy.
How similar studies have gone: Prior work in regional anesthesia for breast surgery suggests regional blocks can reduce analgesic needs, though direct comparison of these two blocks is needed.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 18 and 85 years. * Scheduled for elective mastectomy for breast cancer under general anesthesia. * American Society of Anesthesiologists (ASA) physical status I, II, or III. * Willingness to participate in the study and provide informed consent. Exclusion Criteria: * Refusal to participate in the study. * History of bleeding diathesis or coagulopathy. * Receiving anticoagulant therapy. * Allergy or hypersensitivity to local anesthetics or opioid medications. * History of local anesthetic toxicity. * Infection at the planned block injection site. * Hepatic or renal failure. * Uncontrolled diabetes mellitus. * Uncontrolled hypertension. * Intellectual disability. * Receiving opioid treatment for chronic pain. * Pregnancy, suspected pregnancy, or breastfeeding. * Planned bilateral mastectomy.
Where it's running
-
Bursa City Hospital
Nilufer, Bursa, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Enes Batuhan Cansız, MD
- Email: enbatuca55@gmail.com
- Phone: 05384600660
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.