Postoperative Pain Trajectories After Endometriosis Surgery
Official title: Pain Trajectories After Surgery for Endometriosis: A 6-Month Prospective Monocentric Study
Run by Centre Hospitalier Universitaire, Amiens · NCT07882498 · Data updated 2026-11-12
This study tests how pain changes after endometriosis surgery and whether perioperative pain testing can predict who will have ongoing pain.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 150 (estimated) |
| Sponsor | Centre Hospitalier Universitaire, Amiens Academic / other |
| Locations | 1 site (Amiens) |
| Status | Recruiting |
| Started | July 7, 2026 |
| Main results expected | July 2028 |
| Study ends | January 2029 |
| Registry record updated | October 20, 2026 |
| Trial ID | NCT07882498 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) with imaging-confirmed endometriosis scheduled for surgical treatment and affiliated with the French Social Security system.
✕Probably not a fit
Patients who do not experience chronic postoperative pain or who do not complete follow-up may not derive predictive benefit from the testing.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective, single-centre observational study will follow adults with confirmed endometriosis undergoing surgery to map their pain trajectories at multiple time points up to 6 months. It will combine perioperative quantitative sensory testing with patient-reported outcomes to explore predictors of chronic postoperative pain. The goal is to identify distinct pain patterns and see if early tests can forecast long-term pain after surgery. Analyses will focus on mechanical and pressure pain sensitivity, temporal summation, and standard pain questionnaires. Follow-ups are planned for day 2, day 14, and later time points to characterize trajectory.
Why it matters
Potential benefit: If successful, the study could help clinicians anticipate which patients are at higher risk for persistent pain and tailor perioperative care accordingly.
How similar studies have gone: Prior work shows that pain trajectories and quantitative sensory testing can relate to postoperative pain in other conditions; this study applies similar concepts to endometriosis with observational design.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years * Imaging-confirmed endometriosis * Scheduled surgical treatment for endometriosis * Affiliation to the French Social Security system * Written informed consent obtained Exclusion Criteria: * Patients under legal protection (guardians or curators) * History of psychiatric disorders * Neurodegenerative diseases * Inability to self-assess pain using a numerical rating scale * Non-French-speaking patients * Pregnancy or breastfeeding * Refusal to participate
Where it's running
-
CHU Amiens-Picardie
Amiens, France Recruiting
Study contacts
- Study coordinator: Paul Tarpin
- Email: Tarpin.paul@chu-amiens.fr
- Phone: 33+3.22.08.79.80
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Prevention of chronic postsurgical pain in people who regularly use opioids
This trial tests whether adding a telemedicine post-surgery consult between days 15 and 28 helps reduce long-term pain and opioid use in adults on chronic opioids undergoing elective surgery.
-
Whether intense pain before emergency surgery leads to long-term pain after the operation
We will test whether people having emergency abdominal or orthopedic surgery who have strong pain before the operation are more likely to have ongoing pain three months afterward.
-
Comparing different techniques to treat endometriosis
This study is testing different methods to treat endometriosis, like laser and heat techniques, to see which one works best for relieving pain in women who are already having surgery for the condition.
-
PECS II vs SPSIP nerve blocks for pain after mastectomy
This study tests whether two ultrasound-guided nerve blocks (PECS II and SPSIP) differ in how much opioid patients need after mastectomy.
-
Palatal Shield Technique to Reduce Pain and Improve Healing After Free Gingival Graft
This randomized trial tests whether a collagen sponge with a protective palatal shield made of flowable resin helps reduce pain and improve healing after free gingival graft harvest.
-
Phenotype-based pain management for chronic post-treatment pain after head and neck cancer
We’re testing a personalized pain plan to see if tailoring treatment to a patient’s pain type can reduce chronic pain in adults who completed head and neck cancer treatment.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.