Regional anesthesia for knee replacement: effects on early joint motion and patient satisfaction
Official title: Evaluation of the Effects of Regional Anesthesia Methods Applied in Total Knee Arthroplasty on Joint Range of Motion in the Postoperative Period and Patient Satisfaction
Run by Konya City Hospital · NCT07124494 · Data updated 2026-11-12
We will test whether three different regional anesthesia approaches — an epidural catheter, an adductor canal catheter, or multimodal IV pain control — help adults having elective knee replacement move their knee better and feel more satisfied after surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Konya City Hospital Academic / other |
| Locations | 1 site (Konya, Meram) |
| Status | Recruiting |
| Started | August 5, 2025 |
| Main results expected | December 12, 2026 |
| Study ends | December 19, 2026 |
| Registry record updated | July 22, 2026 |
| Trial ID | NCT07124494 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 years or older scheduled for primary total knee arthroplasty who are ASA physical status I–III, accept neuraxial (spinal) anesthesia, can cooperate, and are literate in Turkish are ideal candidates.
✕Probably not a fit
Patients with contraindications to neuraxial anesthesia (such as coagulopathy, local infection, sepsis), known bupivacaine allergy, severe hypovolemia, demyelinating CNS disease, or those who cannot cooperate or read Turkish are unlikely to be eligible or to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a single-center, prospective, randomized controlled trial at Konya City Hospital enrolling 90 adults undergoing elective primary total knee arthroplasty under spinal anesthesia. Participants are randomly assigned to one of three postoperative analgesia strategies: spinal anesthesia with an epidural catheter, spinal anesthesia with an adductor canal catheter, or spinal anesthesia with multimodal intravenous analgesia. The primary outcome is postoperative knee range of motion measured on postoperative days 1–3, with secondary outcomes including patient satisfaction, Oxford Knee Score, opioid consumption, and VAS pain scores. The study covers the immediate inpatient postoperative period and is planned to be completed within six months.
Why it matters
Potential benefit: If successful, the findings could identify which anesthesia approach improves early knee mobility and patient satisfaction after TKA, potentially speeding recovery and reducing opioid requirements.
How similar studies have gone: Prior trials of regional blocks including adductor canal catheters and epidurals have shown benefits for pain control and earlier mobilization in some settings, but direct head-to-head data specifically focused on early ROM and patient satisfaction remain limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
* Minimum Age: 18 Years * Maximum Age: None * Sex: All * Gender Based: No * Accepts Healthy Volunteers: No * Inclusion Criteria: * Scheduled for primary total knee arthroplasty * Age ≥ 18 years * American Society of Anesthesiologists (ASA) physical status I-III * Accepting neuraxial anesthesia * Exclusion Criteria: * Skin infection at the planned injection site * Sepsis * Coagulopathy * Refusal of neuraxial anesthesia * Severe hypovolemia * Demyelinating central nervous system disease * Age under 18 years * Illiterate in Turkish * Non-cooperative patients * Known allergy or hypersensitivity to bupivacaine
Where it's running
-
Yasin Tire
Konya, Meram, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Yasin Tire
- Email: dryasintire@hotmail.com
- Phone: 05055367970
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.