Aescin (Reparil) versus Ibuprofen for pain, swelling, and limited mouth opening after impacted lower wisdom tooth removal

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center, randomized, single-blind trial enrolling 100 adults who need surgical removal of impacted mandibular third molars at a dental center in Muscat, Oman. Participants are randomly assigned to Reparil (aescin 20 mg three times daily) or ibuprofen (400 mg three times daily) for five days after a standardized extraction. Outcomes include patient-reported pain (VAS), objective facial swelling measured with a 3D facial scanner, and mouth opening measured with a digital caliper, recorded preoperatively, on day 2, and on day 7 post-surgery. The study also monitors adverse events to compare safety profiles between the herbal extract and the NSAID.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients indicated for surgical removal of impacted mandibular third molars according to National Institute for Health and Care Excellence (NICE) guidelines.

Age between 18 and 40 years.

Impacted mandibular third molars with similar anatomical position and difficulty level as classified by Pell and Gregory and Pederson scoring.

Healthy individuals (ASA I-II) with no significant systemic illness.

Willing to provide written informed consent and attend all follow-up visits (Day 2 and Day 7 post-surgery).

Exclusion Criteria:

* Recent use (within three weeks preoperatively) of anti-inflammatories, corticosteroids, or antibiotics.

Known allergies or hypersensitivity to Aescin, Ibuprofen, rescue medications, or local anesthetics.

Pregnant or lactating women.

Patients with contraindications to NSAIDs (e.g., asthma, bleeding disorders, chronic kidney disease, active peptic ulcer, or cardiovascular disease).

Recent use of substances that may affect surgery or interact with study drugs (e.g., contraceptives, alcohol, or tobacco).

Surgical time exceeding 30 minutes or cases with intraoperative complications requiring non-study medications.

Where it's running

• Medical City for Military and Security Services - Dental Center
  Muscat, Al Khoud, Oman Recruiting

Study contacts

• Principal investigator: Suhail H AL Samari, BDS, MFD — Oman Medical Speciality Board
• Study coordinator: Suhail H AlSamari, BDS, MFD
• Email: suhail.dental@gmail.com
• Phone: +968 97366511

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Tea tree oil versus chlorhexidine mouthwash after impacted lower wisdom tooth removal

  This tests whether tea tree oil mouthwash can reduce swelling, pain, limited mouth opening, and help gum healing as well as standard chlorhexidine in adults after extraction of impacted lower wisdom teeth.

  Recruiting Harran University · Sanliurfa · NCT07180498

• Hilotherapy versus Kinesio taping for recovery after bimaxillary jaw surgery

  This study will test whether kinesio taping or hilotherapy reduces swelling, pain, and limited mouth opening in adults after bimaxillary orthognathic (jaw) surgery.

  Recruiting Medipol University · Istanbul, Bağcılar · NCT07006610

• PECS II vs SPSIP nerve blocks for pain after mastectomy

  This study tests whether two ultrasound-guided nerve blocks (PECS II and SPSIP) differ in how much opioid patients need after mastectomy.

  Recruiting Bursa City Hospital · Nilufer, Bursa · NCT07929090

• Palatal Shield Technique to Reduce Pain and Improve Healing After Free Gingival Graft

  This randomized trial tests whether a collagen sponge with a protective palatal shield made of flowable resin helps reduce pain and improve healing after free gingival graft harvest.

  Recruiting Cairo University · Cairo, Cairo Governorate · NCT07926516

• Perfusion Index to Measure Postoperative Pain in Kids After Adenotonsillectomy

  This study tests whether the perfusion index can reliably reflect pain levels in children aged 1–12 after adenotonsillectomy, comparing standard care with an added glossopharyngeal nerve block.

  Recruiting Istanbul University · Istanbul, Istanbul · NCT07915804

• Anterior Knee Nerves Block vs Femoral Nerve Block for Knee Arthroscopy

  This trial tests whether an anterior nerves of the knee (ANK) block provides similar pain relief to a femoral nerve block after knee arthroscopy in adults, aiming to reduce quadriceps weakness.

  Recruiting Van Training and Research Hospital · Van · NCT07910500

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.