Nerve block versus IV pain control after laparoscopic gallbladder removal

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center, prospective, randomized, parallel-group trial will allocate adult patients undergoing elective laparoscopic cholecystectomy to bilateral thoracic paravertebral block, bilateral external oblique intercostal block, or standard systemic analgesia with IV patient-controlled tramadol. All regional blocks are performed under ultrasound guidance after induction of general anesthesia using standardized volumes and concentrations of a long-acting local anesthetic. The primary endpoint is total tramadol consumption within 24 hours after surgery, and secondary outcomes include pain scores, additional analgesic requirements, incidence of nausea/vomiting, time to mobilization, and length of hospital stay. The design tests whether truncal regional techniques provide opioid-sparing analgesia and faster recovery compared with systemic opioid-based regimens.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 18 and 65 years
* Scheduled for elective laparoscopic cholecystectomy under general anesthesia
* ASA physical status I-III
* Able to understand the study procedure and provide informed consent

Exclusion Criteria:

Patient refusal or inability to provide informed consent

Allergy or contraindication to local anesthetics, tramadol, or study medications

Coagulopathy or current anticoagulant therapy

Local infection at the planned block injection site

Severe hepatic or renal impairment

Chronic opioid use or opioid dependence

Neurological or psychiatric disorders affecting pain perception or communication

Pregnancy or breastfeeding

Body mass index (BMI) \> 35 kg/m²

Conversion to open cholecystectomy during surgery

Where it's running

• Cukurova University Faculty of Medicine
  Adana, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Nurefsan Sadikoglu, MD — Cukurova University Hospital
• Study coordinator: Nurefsan Sadikoglu, MD
• Email: nurefsansadikoglu@gmail.com
• Phone: +(90) 538 926 2414

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.