Transdermal buprenorphine patch added to multimodal pain relief after VATS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center, randomized, triple-blind, placebo-controlled trial conducted at Clínica Dávila in Santiago, Chile. Adults undergoing elective unilateral video-assisted thoracoscopic surgery will receive either a 5 mcg/hour transdermal buprenorphine patch plus standard multimodal analgesia or a placebo patch plus standard analgesia. Postoperative pain is measured at 24, 48, 72 hours and 7 days using a 0–10 scale; secondary outcomes include opioid rescue use, length of stay, nausea and vomiting, itching, and urinary retention. The trial aims to determine if adding buprenorphine can further reduce pain and opioid needs beyond multimodal analgesia alone.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18 years or older.
* Scheduled for elective unilateral video-assisted thoracoscopic surgery (VATS).
* American Society of Anesthesiologists (ASA) physical status I-III.
* Able to understand the study procedures and provide written informed consent.

Exclusion Criteria:

* Known allergy or hypersensitivity to buprenorphine or any component of the transdermal patch.
* Chronic opioid use before surgery.
* Severe hepatic impairment.
* Pregnancy or breastfeeding.
* Inability to complete postoperative pain assessments.
* Any condition that, in the investigator's opinion, could interfere with study participation or outcome assessment.

Where it's running

• Clínica Dávila
  Santiago, Santiago Metropolitan, Chile Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.