Condition

Endometriosis clinical trials and research

• 121Clinical trials
• 109NIH research projects
• 3New in 30 days
• 27Countries

Newest Endometriosis clinical trials

All recruiting trials (121)

• Postoperative Pain Trajectories After Endometriosis Surgery

  This study tests how pain changes after endometriosis surgery and whether perioperative pain testing can predict who will have ongoing pain.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07882498

• Imaging endometriosis with a special PET tracer in adult women

  This study tests whether a PET/CT scan using [18F]AlF-FAPI-74 can help detect endometriosis lesions in women who are planning laparoscopy.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT07876648

• Fiber supplement for digestive symptoms in endometriosis

  A fiber-based supplement is being tested to see if it is safe and helps with gut and vaginal microbiomes and digestive symptoms in women with endometriosis.

  Recruiting LOAM Science · San Francisco, California · NCT07875062

• Stellate ganglion block and dexmedetomidine for better sleep after gynecologic laparoscopy

  The study tests whether giving a preoperative stellate ganglion block plus intraoperative dexmedetomidine improves sleep after laparoscopic gynecologic surgery in women.

  Recruiting The Second People's Hospital of Huai'an · Huai'an, Jiangsu · NCT07860203

• Atypical Endometriosis: Histology, Immunophenotype and Molecular Features

  Researchers will look at how endometriotic tissue that looks atypical under the microscope relates to clinical features and ultrasound findings to better separate benign from potentially atypical lesions.

  Recruiting Casa di Cura Dott. Pederzoli · Peschiera del Garda, Verona · NCT07816133

• AI into Ultrasound Diagnostics in Reproductive Medicine

  Researchers are testing AI tools that analyze transvaginal ultrasound images to help detect endometriosis, adenomyosis, uterine masses, and pregnancy-related receptivity in women aged 18-45.

  Recruiting Semmelweis University · Budapest, Budapest · NCT07810920

• Personalized Exercise Recommendations for Chronic Pelvic Pain

  This study tests if an AI-powered, personalized exercise plan can help people with chronic pelvic pain see if tailored workouts work better than standard guidance.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT07810218

• Endometriosis affecting the urinary tract: long-term outcomes and kidney function

  This study looks at how deep endometriosis that touches the urinary tract affects the kidneys over time in adults with hydronephrosis or ureteral blockage.

  Recruiting Charles University, Czech Republic · Prague · NCT07776574

• Leuprorelin-like 3.75 mg injection comparison in endometriosis

  This study tests whether a new formulation of leuprorelin (HHK001) given as a single 3.75 mg injection works similarly or better than Enantone for people with endometriosis.

  Recruiting at 2 sites Phase 1 Zhuhai Huahaikang Pharmaceutical Technology Co., Ltd. · Changsha, Hunan and 1 other locations · NCT07755956

• Endometriosis Clinical Course and Reproductive Outcomes Cohort

  This prospective observational study tests how endometriosis affects pain, cysts, pregnancy, and recurrence over two years in women with endometriosis and matched healthy controls.

  Recruiting Guangdong Women and Children Hospital · Guangzhou, Guangdong · NCT07749053

• Pelvic Floor Therapy plus Exercise for Endometriosis-Related Pelvic Pain

  This 12-week study tests whether specialized pelvic floor physical therapy plus a structured exercise program helps reduce chronic pelvic pain in women with endometriosis more than a placebo version of pelvic floor therapy plus the same exercise plan.

  Recruiting Hospital de Clinicas de Porto Alegre · Porto Alegre, Rio Grande do Sul · NCT07733583

• Making pelvic health physiotherapy more accessible for endometriosis

  This study tests how to improve access to pelvic health physiotherapy for women with endometriosis in Quebec.

  Recruiting Université de Sherbrooke · Sherbrooke, Quebec · NCT07731776

• Cannabinoid-based product for gynecologic pain in endometriosis, adenomyosis, or PID

  This study tests a high-CBD, hemp-derived product against placebo in adults with gynecologic pain from endometriosis, adenomyosis, or PID over one week to see if it reduces pain and related symptoms.

  Recruiting Phase 1/2 Mclean Hospital · Belmont, Massachusetts · NCT07728695

• Biomarkers for Endometriosis: SNCG and BCL6 in blood and menstrual fluid

  This study looks at whether SNCG and BCL6 proteins in blood and menstrual fluid can help diagnose endometriosis without invasive surgery.

  Recruiting Trio Fertility · Toronto, Ontario · NCT07713797

• Pelvic Floor Function and Endometriosis-Related Pelvic Pain in Women

  This study will look at whether endometriosis-related pelvic pain is linked to pelvic floor muscle strength and related factors in women aged 18–50, comparing them with healthy controls.

  Recruiting University of Pecs · Pécs, Baranya · NCT07713108

• Depth of Argon Beam Coagulation in Ovarian Endometriomas

  This study tests how deeply Argon Beam Coagulation affects ovarian tissue during laparoscopic surgery for ovarian endometriomas in women aged 18-40.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern, Canton of Bern · NCT07711743

• Expression of Targets in Endometriotic Lesions

  This study tests molecules in tissue from people with endometriosis to see how their levels differ between endometriotic lesions and normal tissue.

  Recruiting Beijing Tsinghua Chang Gung Hospital · Beijing, Beijing Municipality · NCT07693283

• Ovarian Reserve After Cystectomy for Endometriotic vs. Non-Endometriotic Cysts

  This study tests how laparoscopic removal of ovarian cysts affects ovarian reserve in women with endometriotic cysts compared to benign/non-endometriotic cysts.

  Recruiting Benha University · Banhā, Qalyubia Governorate · NCT07686783

• Self-administered kit to help endometriosis-related sexual pain

  A kit you use at home is being tested to see if it helps reduce painful sex for women with endometriosis.

  Recruiting Elsan · Stains · NCT07683468

• Samphire Guided Care for Wellbeing at Work

  This study tests a 12-week digital program with at-home neuromodulation to see if it helps women with menstrual or perimenopausal symptoms feel better at work and in daily life.

  Recruiting Samphire Group, Inc. · San Francisco, California · NCT07679074

• Whole-Body Cryotherapy to Help Endometriosis Pain

  A small pilot study will test whether short exposures to extreme cold can reduce chronic pelvic pain and improve quality of life for people with endometriosis.

  Recruiting University of Edinburgh · Edinburgh, Scotland · NCT07603960

• PEMF therapy for women with endometriosis

  This trial tests whether pulsed electromagnetic field therapy can reduce pain and improve quality of life for women with endometriosis, compared with a sham treatment, while keeping standard care.

  Recruiting Beni-Suef University · Banī Suwayf · NCT07592403

• Endometriosis self-management in Europe

  This study follows people with endometriosis in Europe to see how daily self-management, support from others, and care systems influence their sense of empowerment or abandonment.

  Recruiting Wageningen University and Research · Wageningen · NCT07591441

• FODMAP Diet for Pelvic Endometriosis With GI Symptoms

  This study tests whether following a low-FODMAP diet can reduce pain and improve quality of life and sexual function in women with endometriosis and gut symptoms.

  Recruiting Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · Milan · NCT07590895

• Menstrual stem cells in endometriosis

  This project will see if menstrual blood stem cells from women with endometriosis behave differently at the molecular and immune levels compared with cells from women without endometriosis.

  Recruiting University Rovira i Virgili · Reus, Tarragona and 1 other locations · NCT07578480

• Educational podcast for people with chronic pelvic pain and endometriosis

  This project will test whether giving adults with chronic pelvic pain or endometriosis access to an educational podcast along with their usual care helps improve quality of life, reduce stigma, or increase satisfaction with care compared with usual care alone.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07568834

• Lab test that uses menstrual blood to diagnose endometriosis.

  This project will test whether a lab test using self-collected menstrual blood can accurately diagnose endometriosis in menstruating women aged 14–49.

  Recruiting at 8 sites Diamens FlexCo · Linz and 7 other locations · NCT07553676

• Imaging endometriosis with total-body PET-CT in women with suspected disease

  This study tests whether total-body PET-CT with special tracers can help identify endometriosis in women who are likely to have the condition and are planning laparoscopy.

  Recruiting University of Edinburgh · Edinburgh, City Of Edinburgh · NCT07523997

• Intra-operative dual laparoscopy and neo-rectoscopy (IDLnR) versus conventional laparoscopy for bowel endometriosis

  We will test whether adding intra-operative dual laparoscopy and neo-rectoscopy (IDLnR) to surgery for women with bowel endometriosis improves bowel function six months after the operation compared with conventional laparoscopy.

  Recruiting Obstetrics & Gynecology Hospital of Fudan University · Shanghai, Shanghai Municipality and 2 other locations · NCT07523308

• Outcomes after emergency gynecology care for pelvic endometriosis or suspected endometriosis

  This project will follow adults who come to a gynecological emergency department with known or suspected endometriosis to see what their outcomes are after emergency care.

  Recruiting Centre Hospitalier Intercommunal Creteil · Créteil · NCT07472842

• Pesticide exposure, cell-free DNA, and gut/genital microbiome signatures in women with endometriosis

  This project will test whether pesticide exposure is linked to oxidative-stress-related changes in circulating cell-free DNA and to differences in the gut and genital microbiomes in women with endometriosis and infertility.

  Recruiting Centre Hospitalier Universitaire, Amiens · Salouël · NCT07471373

• Deep posterior endometriosis surgery and ovarian reserve

  This trial will test whether surgery for severe deep posterior endometriosis changes ovarian reserve in women aged 18 to 39 who do not have ovarian endometriomas.

  Recruiting GCS Ramsay Santé pour l'Enseignement et la Recherche · Quint-Fonsegrives · NCT07469007

• Reproductive outlook for women trying to conceive after medical or surgical treatment for endometriosis

  This study will try to see whether women treated medically or surgically for endometriosis are more likely to need medically assisted reproduction (PMA) and how their conception and pregnancy outcomes compare.

  Recruiting Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · Milan, MI, Italia · NCT07437742

• Immune profile test for women with chronic pelvic pain and endometriosis

  This study tests a functional immune test to see if immune profiles differ in women with chronic pelvic pain and endometriosis who aren’t responding to first-line treatments.

  Recruiting Centre Hospitalier Universitaire de Nice · Nice, Alpes-Maritimes · NCT07429773

• TENS for endometriosis-related pelvic pain

  This study tests whether two types of TENS (conventional and microstimulation) can reduce chronic pelvic pain in adults with endometriosis or adenomyosis who are on stable hormone therapy.

  Recruiting Monath Electronic · Bordeaux · NCT07393295

• See if HMI-115 helps women with moderate to severe endometriosis pain

  This phase 3 study tests whether HMI-115 reduces endometriosis-related pain in premenopausal women compared with placebo over 24 weeks, with a follow-up extension.

  Recruiting Phase 3 Hope Medicine (Nanjing) Co., Ltd · Beijing, Beijing Municipality and 4 other locations · NCT07318688

• Predicting who will get less pain after endometriosis surgery

  This project will use brain scans and questionnaires to try to see if we can predict which people with severe endometriosis will have less pelvic pain after surgery.

  Recruiting University of Oxford · Oxford, Oxfordshire · NCT07313345

• Electroacupuncture for pelvic pain in women with suspected endometriosis

  This study tests whether a series of electroacupuncture sessions can reduce pelvic pain in women awaiting diagnostic laparoscopy for suspected endometriosis.

  Recruiting St. Olavs Hospital · Trondheim · NCT07305025

• Franco-European Institute of Endometriosis long-term outcomes cohort

  This cohort will follow women with confirmed pelvic endometriosis to see if different medical and surgical treatments lead to better long-term symptoms, quality of life, recurrence rates, and fertility outcomes.

  Recruiting Clinique Tivoli Ducos · Bordeaux · NCT07243587

• ENDO1000 — a UK-wide project on endometriosis

  This project will collect symptom reports, medical information, and biological samples from people in the UK with diagnosed endometriosis to try to find patterns that speed diagnosis and improve care.

  Recruiting University of Edinburgh · Edinburgh · NCT07240883

• Surgery first versus IVF-first for people with advanced endometriosis

  This trial will test whether having surgery before assisted reproductive technologies (like IVF) or going straight to IVF gives people with advanced endometriosis a better chance of pregnancy and live birth.

  Recruiting Karolinska Institutet · Stockholm, Stockholm County and 3 other locations · NCT07240363

• Retinal imaging to detect systemic inflammation in endometriosis

  This project will test whether quick, noninvasive eye scans can show signs of systemic inflammation in women and people assigned female at birth who have endometriosis by comparing their retinal images with those of similar people without endometriosis.

  Recruiting University of Edinburgh · Edinburgh, Scotland · NCT07232485

• Selective removal of endometriotic lining from ovarian endometriomas using CUSA Clarity

  This project will try the CUSA Clarity device on tissue from women with ovarian endometriomas to see if it removes endometriotic lining while preserving healthy ovarian tissue.

  Recruiting Kanazawa University · Kanazawa, Ishikawa-ken · NCT07215130

• Good pain consultation for endometriosis

  This trial will test whether adding a 'good pain consultation' with early biopsychosocial pain education to usual care helps biological women with endometriosis manage pain and improve quality of life.

  Recruiting Sorlandet Hospital HF · Kristiansand, Agder · NCT07205614

• Long-term HIFU treatment for rectal endometriosis

  See if high-intensity focused ultrasound (HIFU) provides lasting symptom relief for people who had rectal endometriosis treated with HIFU.

  Recruiting Edap Tms S.a. · Lyon · NCT07179419

• Indinol Forto 200 mg versus Visanne 2 mg for endometriosis pelvic pain

  This will test whether Indinol Forto 200 mg capsules relieve pelvic pain as well and are as safe as Visanne 2 mg tablets in people aged 18–45 with surgically confirmed endometriosis.

  Recruiting at 3 sites Phase 3 Alcea · Kazan' and 7 other locations · NCT07164183

• Dietary guidance and probiotics for pelvic pain in women with endometriosis and IBS

  This trial will try dietary guidance and Lactobacillus probiotics to see if they reduce chronic pelvic pain in women who have both endometriosis and irritable bowel syndrome.

  Recruiting University of Sao Paulo · Catanduva, São Paulo · NCT07149519

• Multidisciplinary educational program to support people with endometriosis

  This program will try a nurse-led multidisciplinary educational support program to help adults with endometriosis manage chronic pelvic pain and improve quality of life.

  Recruiting Centre Hospitalier Emile Roux · Aix-en-Provence and 1 other locations · NCT07134023

• Estradiol-linked inflammation and nerve sensitization in endometriosis pelvic pain treated with relugolix

  This study will try relugolix combination therapy to see if it reduces pelvic pain, inflammation, and pain sensitivity in premenopausal women with moderate-to-severe endometriosis-related pelvic pain.

  Recruiting Phase 3 University of Michigan · Ann Arbor, Michigan · NCT07100782

• Whole-food, plant-based diet for endometriosis pain and quality of life

  This trial will test whether switching to a whole-food, plant-based diet for 12 weeks helps women with endometriosis have less pain and better quality of life.

  Recruiting University of California, San Diego · La Jolla, California · NCT07090096

• Temporary ovarian suspension during laparoscopy to reduce postoperative adhesions

  This study will test whether temporarily lifting and attaching the ovaries to the abdominal wall during laparoscopic surgery reduces ovarian and pelvic adhesions in people having surgery for moderate-to-severe endometriosis.

  Recruiting Carmel Medical Center · Haifa · NCT07087756

• Argon plasma coagulation versus standard cystectomy for ovarian endometrioma

  This trial will test whether argon plasma coagulation preserves ovarian reserve better than standard cystectomy for people having surgery for ovarian endometriomas.

  Recruiting Erbe Elektromedizin GmbH · Tübingen, Germany · NCT07065214

• New [18F]-FES PET/CT imaging to detect and describe endometriosis lesions

  This study will test whether an [18F]-FES PET/CT scan can better find endometriosis lesions and measure estrogen receptor activity in adults scheduled for surgery.

  Recruiting University Hospital, Toulouse · Toulouse · NCT07053982

• Screening for fibromyalgia in women with suspected endometriosis

  This project will test how common fibromyalgia is in women who come to an endometriosis clinic for their first visit.

  Recruiting Assuta Ashdod Hospital · Ashdod · NCT07037251

• HerResolve™ blood test to detect endometriosis in symptomatic women

  This will test whether the HerResolve™ non-invasive blood test can detect endometriosis in women aged 18–49 who have pelvic pain or abnormal bleeding and are scheduled for laparoscopy.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT07006987

• EUmetriosis: new insights into how endometriosis develops

  This study will see if epigenetic changes in menstrual blood and plasma can be used to find a non-invasive test for women with endometriosis.

  Recruiting Université Catholique de Louvain · Brussels · NCT07000786

• Effects of pelvic organ diseases on endometrial receptivity in infertile women

  This study is trying to see how conditions like adenomyosis, fibroids, and endometriosis affect the ability of the uterus to support pregnancy in women who are having trouble getting pregnant.

  Recruiting Charles University, Czech Republic · Prague · NCT06991595

• Wearable brain stimulation device for managing endometriosis pain

  This study tests if a wearable brain stimulation device can help women with endometriosis feel less pain and improve their overall wellbeing.

  Recruiting Samphire Group, Inc. · San Francisco, California · NCT06974773

• Using low-dose ketamine during surgery to treat endometriosis pain

  This study is testing if giving low-dose ketamine during surgery can help reduce pain and improve recovery for people with endometriosis.

  Recruiting Phase 4 Insel Gruppe AG, University Hospital Bern · Bern · NCT06951802

• Probiotics for treating endometriosis

  This study is testing whether taking specific probiotics can help improve gut health and quality of life for people with endometriosis.

  Recruiting The Gut Microbiome Center (Centar za crijevni mikrobiom) · Zagreb · NCT06929364

• Using tDCS stimulation to improve function and reduce pain in neurological and gynaecological patients

  This study is testing if a brain stimulation treatment can help improve movement and reduce pain for people with neurological and gynecological conditions.

  Recruiting Poznan University of Physical Education · Poznan · NCT06891690

• Improving fertility in women with endometriosis through diet during IVF

  This study is testing if following an anti-inflammatory diet for 12 weeks can help women with endometriosis have better fertility results during IVF.

  Recruiting Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · Milan · NCT06885125

• Measuring L-PGDS levels in blood, urine, vaginal fluid and endometrial tissue

  This project will test whether L-PGDS levels in blood, urine, vaginal fluid and uterine tissue differ between women with adenomyosis, other benign uterine conditions, and healthy controls.

  Recruiting Centre Hospitalier Universitaire de Nīmes · Nîmes · NCT06864494

• Identifying ureters during deep endometriosis surgery using indocyanine green dye instead of ureteric stents

  This project will see if injecting indocyanine green dye into the ureters causes less postoperative pain than placing ureteric stents for women aged 18–50 undergoing laparoscopic or robotic surgery for deep endometriosis.

  Recruiting University Hospitals of North Midlands NHS Trust · Stoke-on-Trent, Staffordshire · NCT06852248

• Understanding how the uterus absorbs fluid during early pregnancy

  This study is trying to understand how the uterus absorbs fluid during early pregnancy in women, both with and without endometriosis, to learn more about the process.

  Recruiting Johns Hopkins University · Athens, Georgia and 2 other locations · NCT06847685

• Using an app to improve quality of life for patients with endometriosis

  This study is testing whether using an app can help improve the quality of life and reduce pain for people with endometriosis.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT06821217

• Endometriosis Steroid Profile and Biomarker Discovery

  This study tests a new method to map how steroids are processed in people with and without endometriosis by collecting blood, urine, and vaginal samples to find biomarkers related to the disease.

  Recruiting Nantes University Hospital · Nantes · NCT06820450

• Evaluating physical therapy for endometriosis pain management

  This study is testing if a mix of education about pain and specific exercises can help women with endometriosis feel less pain and improve their quality of life.

  Recruiting University of Seville · Seville · NCT06795243

• Using FAPI PET-CT to diagnose endometriosis

  This study is testing a new imaging method called FAPI PET-CT to see if it can help diagnose endometriosis in patients before they have surgery.

  Recruiting Ziv Hospital · Safed · NCT06792318

• Investigating pain and hormone levels in migraine and endometriosis patients

  This study is trying to see how pain responses and hormone levels differ in people with migraines, endometriosis, both conditions, and healthy individuals.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT06785129

• Assessing Central Awareness in Women with Endometriosis

  This study is trying to see how common a condition called Central Sensitisation Syndrome is in women with endometriosis and how it relates to their chronic pelvic pain.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna · NCT06773065

• Stanford program to advance robotic surgery for children and adolescents

  This program will try the da Vinci Xi surgical robot in children and adolescents (ages 6–21, ≥15 kg) to see if it is safe and works well for procedures like sleeve gastrectomy, cholecystectomy, splenectomy, hysterectomy, and operations for endometriosis.

  Recruiting Stanford University · Stanford, California · NCT06671639

• Improving diagnosis of endometriosis and adenomyosis using advanced analysis techniques

  This study is trying to find better ways to diagnose endometriosis and adenomyosis in women by using advanced techniques that look at genetics and imaging to help personalize treatments.

  Recruiting IRCCS San Raffaele · Catanzaro, Catanzaro and 1 other locations · NCT06572852

• Yoga to reduce endometriosis-related pelvic pain

  This 12-week program will test if practicing yoga can reduce pelvic pain in women aged 18–45 with surgically confirmed endometriosis.

  Recruiting Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT06559852

• Using osteopathic techniques to improve quality of life after endometriosis surgery

  This study is testing if osteopathic techniques can help women feel better and improve their quality of life after surgery for endometriosis by reducing painful complications.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT06553989

• Group care program for treating endometriosis-related pain

  This study is testing a new group care program called PEEPS to see if it can help people aged 18 to 48 with endometriosis-related pain feel better compared to those who just get regular support.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT06549985

• Comparing Implantable Gestrinone and Oral Dienogest for Endometriosis Treatment

  This study is testing whether an implantable form of Gestrinone works better than the oral medication Dienogest for relieving endometriosis symptoms in women aged 18 to 45.

  Recruiting at 4 sites Phase 4 Bio Meds Pharmaceutica Ltda · Campina Grande, Paraíba and 3 other locations · NCT06543550

• Effect of GnRH Agonist on Endometriosis Cysts

  This study tests if a new medication can help women aged 18 to 40 with endometriosis cysts feel less pain and have fewer side effects before and after surgery.

  Recruiting Phase 3 Rumah Sakit Pusat Angkatan Darat Gatot Soebroto · Jakarta · NCT06525155

• Mapping the cellular landscape of endometriosis

  This study is trying to understand the differences between healthy tissue and endometriosis by looking at samples from women during their menstrual cycles to see how certain cells and hormones are involved in the condition.

  Recruiting University Hospital, Toulouse · Toulouse · NCT06502548

• Try the elleFA app to help track endometriosis symptoms and treatments.

  This project will try a smartphone app called elleFA to help pre-menopausal women with known or suspected endometriosis who are receiving care at the McGill University Health Centre track symptoms and treatments more accurately.

  Recruiting McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT06452407

• Comparing robot-assisted and traditional laparoscopic surgery for endometriosis

  This study is testing whether robot-assisted surgery is safer and more effective than traditional surgery for women with deep endometriosis who need a total hysterectomy.

  Recruiting at 2 sites GCS Ramsay Santé pour l'Enseignement et la Recherche · Aix-en-Provence and 1 other locations · NCT06445179

• Comparing quality of life after surgery for endometriosis with and without medication

  This study is testing if a new combination therapy after surgery for endometriosis can improve the quality of life for women who have had the surgery.

  Recruiting Phase 3 Main Line Health · Wynnewood, Pennsylvania · NCT06439524

• Immune signals and regulatory T cells in migraine

  This research will test whether blood immune markers and regulatory T cells are linked to migraine in women ages 18–50 who have migraine or certain autoimmune/inflammatory conditions.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand, AURA · NCT06426316

• Analyzing salivary microRNA in endometriosis patients and their response to progestin therapy

  This study is testing if analyzing saliva can help identify which women with endometriosis will respond well to a specific hormone treatment.

  Recruiting University of Udine · Udine, UD · NCT06414720

• Comparing different techniques to treat endometriosis

  This study is testing different methods to treat endometriosis, like laser and heat techniques, to see which one works best for relieving pain in women who are already having surgery for the condition.

  Recruiting TriHealth Inc. · Cincinnati, Ohio · NCT06414083

• Comparing different techniques to treat endometriosis

  This study is testing different methods to treat endometriosis, like laser and heat techniques, to see which one works best for relieving pain in women who are already having surgery for the condition.

  Recruiting TriHealth Inc. · Cincinnati, Ohio · NCT06414083

• Identifying factors affecting hormonal treatment response in endometriosis patients

  This study is trying to find out why some women with endometriosis don’t respond to hormonal treatments by looking at their symptoms and ultrasound results.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, BO · NCT06413381

• Analyzing saliva for diagnosing gynecological conditions

  This study is testing if analyzing saliva can help doctors diagnose gynecological conditions like endometriosis and ovarian cancer in both patients with symptoms and those without.

  Recruiting at 5 sites Ziwig · Angers and 12 other locations · NCT06392997

• Registry for treating parietal endometriosis with cryoablation and surgery

  This study is tracking how well cryoablation and surgery work for people with parietal endometriosis over three years.

  Recruiting at 14 sites Centre Hospitalier Intercommunal Creteil · Bordeau and 17 other locations · NCT06356831

• Using magnetic stimulation to reduce pain from endometriosis

  This study is testing whether a type of magnetic stimulation can help people with endometriosis pain who haven't found relief from other treatments.

  Recruiting University of Ottawa · Ottawa, Ontario · NCT06333353

• Investigating the effects of diet and therapy on endometriosis pain

  This study is testing whether an anti-inflammatory diet and therapy can help women with endometriosis feel less pain and improve their quality of life.

  Recruiting at 5 sites Radboud University Medical Center · 's-Hertogenbosch and 4 other locations · NCT06332560

• Creating a tissue model to enhance care for endometriosis

  This study is trying to create a new tissue model to help doctors better understand endometriosis and see how different hormonal treatments might work for patients.

  Recruiting at 2 sites Hospices Civils de Lyon · Bron and 1 other locations · NCT06331676

• Investigating the link between endometriosis and microbiota

  This study is trying to see if the bacteria in the bodies of women with endometriosis play a role in their condition by collecting and analyzing different samples from them.

  Recruiting Zhujiang Hospital · Guangzhou, Guangdong · NCT06266897

• Identifying biomarkers for endometriosis using menstrual blood

  This study is trying to find markers in menstrual blood that can help diagnose and understand endometriosis in women aged 18-45, both those with the condition and those without.

  Recruiting Institut National de la Santé Et de la Recherche Médicale, France · Paris · NCT06245512

• Therapeutic physiotherapy for pain and quality of life in women with endometriosis

  This study is testing if a combination of exercise and pain education can help women with endometriosis feel better and improve their quality of life compared to just receiving pain education.

  Recruiting University of Valencia · Valencia · NCT06212349

• Digital mindfulness program for managing endometriosis

  This study is testing a digital mindfulness program to see if it can help people with endometriosis manage their pain and improve their quality of life.

  Recruiting at 2 sites University of Aarhus · Aarhus, Central Jutland and 1 other locations · NCT06211231

• Tele-rehabilitation for chronic pelvic pain in endometriosis

  This study is testing a tele-rehabilitation program to see if it can help women with endometriosis and chronic pelvic pain feel better through online sessions that include pain education and exercises.

  Recruiting University of Alcala · Alcalà de Henares, Madrid · NCT06209346

• Esketamine for treating chronic pain from endometriosis

  This study is testing whether esketamine can help women with endometriosis feel less chronic pelvic pain compared to a placebo.

  Recruiting Phase 3 Reinier de Graaf Groep · Delft · NCT06161805

• Internet-based therapy for endometriosis and chronic pain

  This study is testing an online therapy program for people with endometriosis and chronic pain to see if it helps them feel better and manage their symptoms.

  Recruiting Skane University Hospital · Lund, Skåne County · NCT06153303

• Understanding pain in patients with endometriosis and pelvic pain

  This study looks at what causes chronic pelvic pain in people with and without endometriosis and checks how pain and hormone levels change after surgery to remove endometriosis lesions.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT06101303

• Comparing two types of sutures for vaginal cuff closure in laparoscopic hysterectomy

  This study is testing whether a new type of suture can close the vaginal cuff faster than a standard suture for women having laparoscopic hysterectomy, without causing more complications.

  Recruiting at 2 sites Aesculap AG · Frankfurt am Main, Hesse and 1 other locations · NCT06024109

• Evaluating bone health in women with uterine fibroids or endometriosis using a medication

  This study is testing if a new medication can help improve bone health in women with uterine fibroids or endometriosis who have heavy bleeding or pain.

  Recruiting at 120 sites Phase 3 Sumitomo Pharma Switzerland GmbH · Mobile, Alabama and 119 other locations · NCT05862272

• Analyzing the microbiome in women with endometriosis and unexplained infertility

  This study is testing how the gut and other microbiomes in women with endometriosis or unexplained infertility might be linked to their symptoms and quality of life.

  Recruiting Jagiellonian University · Krakow · NCT05824819

• Pelvic MRI to check organ mobility in endometriosis.

  This project will use dynamic (cine) pelvic MRI to see if measuring pelvic organ movement helps diagnose and explain symptoms of endometriosis in women referred for pelvic MRI.

  Recruiting University Hospital, Lille · Lille · NCT05779462

• Impact of preoperative immunonutrition on recovery after bladder surgery

  This study tests if special nutritional drinks before bladder surgery can help patients recover better and have fewer complications afterward.

  Recruiting at 4 sites Phase 3 Centre Hospitalier Universitaire Vaudois · Lausanne, Canton of Vaud and 3 other locations · NCT05726786

• MetriDx uterine biopsy test to find endometriosis biomarkers

  This test tries to see if a simple uterine biopsy sent to a lab and analyzed by MetriDx's AI can detect endometriosis in people who are having or recently had laparoscopy.

  Recruiting at 2 sites Phase 2 Hera Biotech, Inc. · Saginaw, Michigan and 2 other locations · NCT05698212

• Investigating blood and tissue markers for diagnosing endometriosis

  This study is trying to find blood and tissue markers that can help doctors diagnose endometriosis earlier and more accurately in women who are having surgery for suspected cases.

  Recruiting at 2 sites Region Stockholm · Stockholm, Huddinge and 2 other locations · NCT05339451

• Using a deep neural network to help diagnose endometriosis in women with chronic pelvic pain

  This study is testing a new tool called EndoCheck to see if it can help doctors diagnose endometriosis in women who have chronic pelvic pain, comparing its results to traditional surgery.

  Recruiting at 10 sites Aspira Women's Health · Chandler, Arizona and 9 other locations · NCT05245695

• Comparing robotic and laparoscopic surgery for deep endometriosis

  This study is testing whether robot-assisted surgery is better than regular laparoscopic surgery for people with deep endometriosis in terms of pain relief and quality of life after the procedure.

  Recruiting University of Oulu · Oulu · NCT05179109

• Understanding inflammation's role in cardiovascular risk for women with endometriosis

  This study is testing whether a new pill can help women with endometriosis improve their heart health by looking at how inflammation affects their risk for heart disease.

  Recruiting Early Phase 1 Penn State University · University Park, Pennsylvania · NCT05069740

• Observational study on women with endometriosis and adenomyosis

  This study is gathering health information from women with endometriosis and adenomyosis to see how their quality of life and reproductive health are affected, in hopes of finding better treatment options for different patient needs.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT04862000

• A platform for collecting health data on ME/CFS and Long Covid

  This study is trying to collect health information from adults with ME/CFS and Long Covid to help researchers better understand these conditions and improve future treatments.

  Recruiting Brain Inflammation Collaborative · Delafield, Wisconsin · NCT04806620

• Comparing proton and intensity modulated radiation therapy after surgery for cervical or endometrial cancer

  This study tests whether proton radiation therapy causes fewer side effects than intensity modulated radiation therapy in patients who have had surgery for cervical or endometrial cancer.

  Recruiting Mayo Clinic · Scottsdale, Arizona and 2 other locations · NCT04567771

• Understanding the progression of endometriosis and adenomyosis

  This study is trying to see if endometriosis and adenomyosis get worse over time by looking at symptoms and other factors to help improve diagnosis and treatment for those affected.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT04481321

• Using GnRH agonist to improve pregnancy rates in women with endometriosis or adenomyosis before embryo transfer

  This study is testing if giving GnRH agonists to women with endometriosis or adenomyosis before frozen embryo transfer can help improve their chances of getting pregnant.

  Recruiting Phase 2/3 Hopital Foch · Suresnes · NCT04356664

• Non-invasive treatment for chronic pelvic pain from endometriosis

  This study is testing a new non-invasive treatment using nerve stimulation to see if it can help women with chronic pelvic pain from endometriosis feel better.

  Recruiting Hopital Foch · Suresnes, Île-de-France Region · NCT04177511

• How ovarian stimulation affects blood clot (fibrin) properties

  This trial will test whether different ovarian stimulation methods change blood clotting and the body's ability to break down clots in women with infertility preparing for assisted reproductive treatment.

  Recruiting Jagiellonian University · Krakow, Małopolska · NCT04166825

• Collection of biological samples from patients with pelvic gynecological cancer and endometriosis

  This study is collecting samples from patients with pelvic gynecological cancers and endometriosis to see if they can find clues that help predict cancer recurrence and improve personalized treatments.

  Recruiting at 2 sites Centre Hospitalier Intercommunal Creteil · Créteil and 1 other locations · NCT03622983

• Complete colorectal deep infiltrating endometriosis surgery before IVF to improve fertility

  This trial tests whether having complete surgery for colorectal deep infiltrating endometriosis before in vitro fertilization (IVF) helps women with endometriosis and infertility get pregnant.

  Recruiting at 5 sites University Hospital, Lille · Clermont-Ferrand and 4 other locations · NCT02948972

• Investigating the link between food consumption and fertility in women with endometriosis

  This study is trying to see if certain foods can affect fertility in women with endometriosis.

  Recruiting University of Aarhus · Aarhus · NCT01946698

• New diagnostic tools and treatments for endometriosis

  This study is trying out new ways to diagnose and treat endometriosis in women to see how they can better manage the condition.

  Recruiting Turku University Hospital · Helsinki and 3 other locations · NCT01301885

NIH-funded research (newest 40 of 109)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Molecular clues to endometriosis-related infertility

  This grant explores how molecular changes in endometriosis contribute to infertility, with the aim of finding better ways to diagnose and treat the condition.

  NIH research University of Missouri-Columbia · Columbia, United States · NIH-11595518

• Hormonal Influences on Inflammation in Endometriosis

  A study in adult women with endometriosis looks at how hormones and immune pathways interact to influence inflammation and symptoms.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11588229

• How genes influence endometriosis in women of different racial and ethnic backgrounds

  The team will compare genetic changes in tissue from women of various races who have endometriosis to find molecular targets for better treatments.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11464658

• Quantum diamond sensor endoscopy to map iron in endometriosis

  A tiny quantum sensor built into an endoscope will map iron in endometriosis lesions to help diagnose the disease noninvasively.

  NIH research University of Florida · Gainesville, United States · NIH-11439445

• Understanding how RPLP1 affects endometriosis and adenomyosis

  A patient-focused look at how a ribosomal protein called RPLP1 may drive tissue changes in endometriosis and adenomyosis and what this could mean for future therapies.

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11434812

• CXCR4 methylation in endometriosis and its role as an early biomarker and non-hormonal therapy target

  This project explores how changes in CXCR4 gene regulation may help diagnose endometriosis earlier and point toward non-hormonal treatments for the condition.

  NIH research Marshall University · Huntington, UNITED STATES · NIH-11424504

• Hormonal links to inflammation in endometriosis

  A study to understand how hormones influence immune signals in endometriosis to help explain symptoms and identify potential targets for treatment.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11419789

• Gut microbiota and endometriosis: a microbiome-based approach to understanding and treating pain and lesions

  Researchers are studying how the gut microbiome might influence endometriosis to guide new, nonhormonal treatments for symptoms like pelvic pain and infertility.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11391968

• Plasma protein patterns linked to long-term pelvic pain in endometriosis from teens to adults

  This project looks for blood protein patterns that show which adolescents and young adults with endometriosis are likely to develop long-lasting pelvic pain.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11387137

• Targeting CMG2 to relieve endometriosis pain

  Trying a new drug approach that blocks a protein called CMG2 to reduce pelvic pain in people with endometriosis.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11385649

• Endometriosis and heart disease risk in women with reproductive history details

  This grant studies whether women with endometriosis have higher chances of developing heart and blood vessel problems, using large health records to follow outcomes over many years.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11383429

• Non-hormonal nanodrug targeting endometriosis lesions

  A tiny nanoparticle treatment using cerium oxide bound to albumin aims to shrink endometriosis lesions and ease pain without hormonal therapy.

  NIH research Michigan State University · East Lansing, United States · NIH-11365825

• Vaginal microbiome and nerve signals in endometriosis pain

  This grant studies how bacteria in the vagina influence pain in people with endometriosis, using mouse models and probiotic approaches to find new ways to relieve pain.

  NIH research University of Texas Dallas · Richardson, United States · NIH-11355520

• Rimegepant for Endometriosis Pain in Women 18–45

  A Phase II study to see if the CGRP blocker rimegepant can reduce pelvic pain in women with endometriosis who are 18–45 years old.

  NIH research Mayo Clinic Arizona · Scottsdale, United States · NIH-11346506

• Nanoparticle therapy to target endometriosis in women

  A new nanoparticle-based treatment aims to melt endometriosis lesions using a special chemistry approach to kill cells causing pain, with the goal of reducing surgery and preserving fertility.

  NIH research Oregon State University · Corvallis, United States · NIH-11344411

• Oral treatment to slow endometriosis and reduce pain

  This project tests an oral drug to slow endometriosis progression and ease pain, with the goal of reducing the need for repeated surgeries.

  NIH research Sur180 Therapeutics, LLC · Mcallen, United States · NIH-11331307

• Phytotherapy for Endometriosis using Withaferin-A

  A doctor-scientist at a U.S. university is testing a plant-based compound to help reduce endometriosis symptoms and improve fertility in affected women, using a preclinical model to explore how it might work.

  NIH research Texas A&m University · College Station, United States · NIH-11330521

• Targeting gut-support cells to relieve endometriosis symptoms

  This project looks at whether calming certain gut-support cells can reduce gut pain and inflammation for people with endometriosis.

  NIH research Ponce School of Medicine · Ponce, United States · NIH-11328783

• Understanding how genes shape endometriosis severity using single-cell multi-omics

  Researchers will map how genetic and epigenetic factors contribute to different severities of endometriosis to help improve diagnosis and future treatments for people living with the condition.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11324620

• Non-invasive menstrual biomarker test for endometriosis in infertility patients

  A non-invasive test using menstrual fluid is being developed to help diagnose endometriosis in people dealing with infertility.

  NIH research Nextgenjane, INC. · Oakland, UNITED STATES · NIH-11321735

• Cell enzymes (kinases) as new treatment targets for endometriosis

  The team is seeing whether blocking certain cell enzymes called kinases could lead to new medicines for people with endometriosis.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11319871

• Non-hormonal therapy aiming to cure endometriosis

  A new non-hormonal treatment called ENDO-205 is being developed to cure endometriosis by targeting the disease directly.

  NIH research Endomet Biosciences, INC · Irvine, UNITED STATES · NIH-11319057

• Understanding subtypes of endometriosis-linked ovarian cancer

  This project looks at genetic subgroups of two endometriosis-associated ovarian cancers to find connections with survival and factors like smoking and body weight for people with these cancers.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11312707

• Biomarkers and pathways behind persistent endometriosis pain

  This project looks for immune and inflammatory signals in adolescent and adult women with endometriosis to spot who may develop long-lasting pelvic pain.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11309169

• Predicting who may develop endometriosis and related long-term health problems

  This project will build tools that combine genetic, clinical, and lifestyle information to predict which people are likely to develop endometriosis and later health issues.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11308286

• What causes pain in endometriosis

  This project will look at hormone levels, pain-processing in the nervous system, and tissue markers in people with pelvic pain who are having laparoscopic surgery to find links to more or less pain.

  NIH research Washington University · Saint Louis, United States · NIH-11302715

• Developing a new non-hormonal treatment for endometriosis

  This study is working on a new treatment for endometriosis that doesn't use hormones and aims to actually change the disease instead of just easing the symptoms, and women with this condition may have a chance to join clinical trials as the research moves forward.

  NIH research Endomet Biosciences, INC · Irvine, UNITED STATES · NIH-11300271

• EASE-ENDO: A Mind-Body Virtual Group to Help Endometriosis-Related Pain

  A group video program designed to empower people with endometriosis to manage pain and improve daily life through mind-body strategies.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11289289

• Understanding the Endometriosis-Related Microbiome and Metabolism to Improve Pain Care

  A research project at a major university will look at how gut and reproductive tract microbes and NAD+ metabolism relate to endometriosis pain to help tailor treatments.

  NIH research University of Florida · Gainesville, United States · NIH-11281804

• Endometriosis and future heart disease risk in women and girls

  This NIH grant explores how endometriosis in girls and women is linked to higher risk of heart disease later in life.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11277615

• Endometriosis, the microbiome, and the immune system

  A small study will look at how the reproductive microbiome and immune cells called neutrophils interact in women with endometriosis and pelvic pain or infertility.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11260319

• GATA proteins' role in endometriosis

  Researchers will compare uterine lining tissue from women with and without endometriosis to learn how changes in GATA proteins may cause the condition.

  NIH research Northwestern University · Chicago, United States · NIH-11248425

• Genetic and cell-level changes in endometriosis across diverse women

  This work looks for genetic changes and cell-level differences in endometriosis tissues from women of different racial and ethnic backgrounds to find new treatment targets.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11242059

• Investigating heart disease risk in women with endometriosis

  This study is looking at how endometriosis might raise the risk of heart problems in women and how common treatments for endometriosis could affect heart health, with the goal of finding better ways to keep both your reproductive and heart health in check.

  NIH research Pennsylvania State University, the · University Park, United States · NIH-11239443

• Developing faster tests for diagnosing endometriosis

  This study is working to create new, easy-to-use tests for endometriosis that can be quickly available to patients, making it faster and simpler for women to get the help they need.

  NIH research Venturewell · Hadley, United States · NIH-11219925

• Improving diagnostic technologies for endometriosis

  This study is working on creating better and faster tests for endometriosis, so patients can get the help they need more easily and quickly.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11219917

• Targeting lipid signaling to relieve endometriosis pain

  A research project at Boston Children’s Hospital is exploring new drug targets in the body’s fat-derived signaling system to reduce pain from endometriosis and lessen reliance on opioids.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11201361

• How hormones change inflammation in endometriosis

  This project looks at how sex hormones alter immune and inflammatory processes in people with endometriosis to find clues for better treatments.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11197620

• Developing a new non-hormonal treatment for endometriosis

  This study is testing a new treatment called ENDO-205 for endometriosis, which aims to help women by targeting the disease directly without the side effects of current options, making it a promising step towards better health for those affected.

  NIH research Endomet Biosciences, INC · Irvine, UNITED STATES · NIH-11186444

• A new non-invasive test for diagnosing endometriosis in women facing infertility

  This study is working on a simple and non-invasive test using menstrual fluid to help diagnose endometriosis earlier, which could make it easier for women to get the care they need and improve their chances of having children.

  NIH research Nextgenjane, INC. · Oakland, UNITED STATES · NIH-11185524

Related topics

Quick answers

How many Endometriosis clinical trials are recruiting right now?

121, as of November 12, 2026. 3 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 27 countries. The most sites are in France (27 trials), United States (23 trials), Italy (8 trials), China (8 trials), United Kingdom (6 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 8, Phase 4: 2, Phase 1/2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →