Non-hormonal therapy aiming to cure endometriosis
Official title: Novel, Non-hormonal Therapeutic for Endometriosis
Funded at Endomet Biosciences, INC · NIH-11319057 · Data updated 2026-11-12
A new non-hormonal treatment called ENDO-205 is being developed to cure endometriosis by targeting the disease directly.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Endomet Biosciences, INC NIH-funded |
| Lab location | 1 site (Irvine, UNITED STATES) |
| Project start | April 10, 2025 |
| Project end | March 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $2,045,762 |
| NIH project number | 5SB1HD118921-02 |
| Project ID | NIH-11319057 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals diagnosed with endometriosis who have limited response to current hormonal or surgical treatments and are seeking non-hormonal options.
✕Less likely to help
Patients seeking immediate symptom relief without disease modification may not directly benefit until long-term outcomes are established.
What this research studies
This project aims to create ENDO-205, a disease-modifying therapy that specifically targets endometriosis tissue to stop its progression. The work focuses on a pathway involved in tissue migration and invasion, with the goal of a cure that avoids hormonal side effects. The research team at Endomet Biosciences, led by Tanya Christina Petrossian, will test this therapy's tissue-selective action and potential to reduce symptoms and recurrence after standard treatments.
Why it matters
Potential benefit: If successful, patients may experience lasting relief from endometriosis without hormonal therapies, potentially reducing surgeries and improving fertility outcomes.
How similar studies have gone: Previous studies targeting downstream pathways in endometriosis have shown promise, but a disease-modifying, non-hormonal approach remains to be proven in humans.
Where this research is happening
-
Endomet Biosciences, INC
Irvine, United States Active
Researchers
- Principal investigator: Petrossian, Tanya Christineh — Endomet Biosciences, INC
- Study coordinator: Petrossian, Tanya Christineh
Related research
Other NIH-funded projects on the same topics.
-
Molecular clues to endometriosis-related infertility
This grant explores how molecular changes in endometriosis contribute to infertility, with the aim of finding better ways to diagnose and treat the condition.
-
Hormonal Influences on Inflammation in Endometriosis
A study in adult women with endometriosis looks at how hormones and immune pathways interact to influence inflammation and symptoms.
-
How genes influence endometriosis in women of different racial and ethnic backgrounds
The team will compare genetic changes in tissue from women of various races who have endometriosis to find molecular targets for better treatments.
-
Quantum diamond sensor endoscopy to map iron in endometriosis
A tiny quantum sensor built into an endoscope will map iron in endometriosis lesions to help diagnose the disease noninvasively.
-
Understanding how RPLP1 affects endometriosis and adenomyosis
A patient-focused look at how a ribosomal protein called RPLP1 may drive tissue changes in endometriosis and adenomyosis and what this could mean for future therapies.
-
CXCR4 methylation in endometriosis and its role as an early biomarker and non-hormonal therapy target
This project explores how changes in CXCR4 gene regulation may help diagnose endometriosis earlier and point toward non-hormonal treatments for the condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.