Endometriosis Clinical Course and Reproductive Outcomes Cohort
Official title: Guangdong Provincial Endometriosis Clinical Research Cohort
Run by Guangdong Women and Children Hospital · NCT07749053 · Data updated 2026-11-12
This prospective observational study tests how endometriosis affects pain, cysts, pregnancy, and recurrence over two years in women with endometriosis and matched healthy controls.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 716 (estimated) |
| Sponsor | Guangdong Women and Children Hospital Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Status | Recruiting |
| Started | February 2, 2026 |
| Main results expected | July 2029 |
| Study ends | July 2029 |
| Registry record updated | August 6, 2026 |
| Trial ID | NCT07749053 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women 18–45 with diagnosed endometriosis and age- and BMI-matched healthy controls who can commit to 2 years of follow-up.
✕Probably not a fit
Patients who do not have endometriosis or who cannot complete follow-up may be unlikely to benefit from findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a 24-month prospective observational cohort enrolling women aged 18–45 with endometriosis and age- and BMI-matched healthy controls. Participants receive routine clinical care; no treatments are assigned by the study. Baseline data include demographics, reproductive history, pain scores, lesion characteristics, and treatment history. Follow-ups occur every 3 months in year one and every 6 months in year two to track cyst/pain recurrence, pregnancy outcomes, live birth, and long-term complications. The study will explore associations between disease characteristics, rASRM stage, routine therapies, and subsequent outcomes, and aims to establish an endometriosis clinical research database.
Why it matters
Potential benefit: If successful, the study could improve understanding of how endometriosis progresses and how baseline factors relate to reproductive outcomes, informing future patient care.
How similar studies have gone: Previous observational cohorts have helped describe disease patterns and outcomes in endometriosis, though this specific design to link baseline characteristics with long-term reproductive outcomes adds novel aspects.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Inclusion Criteria: Female participants aged 18 to 45 years. Able and willing to provide written informed consent. For the endometriosis cohort: diagnosis of endometriosis based on clinical findings, imaging, and/or laparoscopy. For the endometriosis cohort: availability of complete baseline clinical data, including revised American Society for Reproductive Medicine stage and lesion type. For the healthy control cohort: healthy women matched by age and body mass index to participants in the endometriosis cohort. For the healthy control cohort: regular menstrual cycles of 28 to 30 days. Exclusion Criteria: For the endometriosis cohort: concurrent malignant tumor or severe cardiac, hepatic, or renal disease. For the endometriosis cohort: previous hysterectomy. For the endometriosis cohort: a mental disorder that prevents adherence to study follow-up. Exclusion Criteria: \-
Where it's running
-
Guangdong Women and Children Hospital
Guangzhou, Guangdong, China Recruiting
Study contacts
- Study coordinator: Li Li, MD
- Email: lili-1406@163.com
- Phone: +85213631446859
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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This study is testing different methods to treat endometriosis, like laser and heat techniques, to see which one works best for relieving pain in women who are already having surgery for the condition.
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This study tests how pain changes after endometriosis surgery and whether perioperative pain testing can predict who will have ongoing pain.
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Imaging endometriosis with a special PET tracer in adult women
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A fiber-based supplement is being tested to see if it is safe and helps with gut and vaginal microbiomes and digestive symptoms in women with endometriosis.
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Stellate ganglion block and dexmedetomidine for better sleep after gynecologic laparoscopy
The study tests whether giving a preoperative stellate ganglion block plus intraoperative dexmedetomidine improves sleep after laparoscopic gynecologic surgery in women.
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Atypical Endometriosis: Histology, Immunophenotype and Molecular Features
Researchers will look at how endometriotic tissue that looks atypical under the microscope relates to clinical features and ultrasound findings to better separate benign from potentially atypical lesions.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.