Mapping the cellular landscape of endometriosis
Official title: Establishing an Endometriosis Transcriptomic Cell Atlas to Decipher the Pathophysiological Role of Stem Cells and Estrogens in the Disease
Run by University Hospital, Toulouse · NCT06502548 · Data updated 2026-11-12
This study is trying to understand the differences between healthy tissue and endometriosis by looking at samples from women during their menstrual cycles to see how certain cells and hormones are involved in the condition.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 92 (estimated) |
| Sponsor | University Hospital, Toulouse Academic / other |
| Locations | 1 site (Toulouse) |
| Status | Recruiting |
| Started | September 27, 2024 |
| Main results expected | September 2027 |
| Study ends | September 2027 |
| Registry record updated | November 5, 2026 |
| Trial ID | NCT06502548 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include women aged 18 to 45 with stage III or IV endometriosis requiring surgery and healthy women undergoing tubal ligation or hysterectomy for benign reasons.
✕Probably not a fit
Patients with non-surgically treated endometriosis or those currently on hormonal treatment may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to explore the cellular diversity between normal endometrial tissue and endometriotic lesions by analyzing samples collected from women at different menstrual phases. It focuses on identifying potential stem cells and the immune environment that contribute to endometriosis, utilizing advanced techniques such as transcriptomics and imaging analysis. Additionally, the study will develop organoid models to investigate the role of estrogen signaling in women with and without endometriosis, providing insights into the disease's initiation and progression.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and targeted treatments for endometriosis and related infertility.
How similar studies have gone: While there have been studies exploring aspects of endometriosis, this approach combining transcriptomics and organoid models is relatively novel and untested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients over 18 and under 45 years of age * Patients with multiple endometriosis sites (superficial, deep and endometriomas) with an indication for surgery to treat disabling painful symptoms and stage III or IV endometriosis in the context of infertility. * Healthy patients including those operated on between the ages of 18 and 45 for tubal ligation * Healthy patients operated on between the ages of 18 and 45 for hysterectomies for benign causes other than endometriosis or adenomyosis * Patients operated on strictly at the time of menstruation * Participants who have not been on hormonal treatment for 2 months * Participant having signed the free and informed consent form * Membership of a Social Security scheme or equivalent Exclusion Criteria: * Patients with endometriosis non-surgically treated * Patients with endometriosis receiving hormonal treatment at the time of surgery or having received hormonal treatment in the 2 months prior to surgery * Patients with adenomyosis only * Healthy non-endometriotic patients undergoing hysterectomy for infectious or malignant causes * Patients benefiting from a legal protection measure (guardianship, curatorship, safeguard of justice) * Patients with positive serology for human immunodeficiency virus (HIV), human T-lymphotropic virus (HTLV), hepatitis B (HBV) and hepatitis C (HCV)
Where it's running
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University Hospital Toulouse
Toulouse, France Recruiting
Study contacts
- Principal investigator: Elodie CHANTALAT, MD — University Hospital, Toulouse
- Study coordinator: Elodie CHANTALAT, MD
- Email: chantalat.e@chu-toulouse.fr
- Phone: 0561323953
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Pesticide exposure, cell-free DNA, and gut/genital microbiome signatures in women with endometriosis
This project will test whether pesticide exposure is linked to oxidative-stress-related changes in circulating cell-free DNA and to differences in the gut and genital microbiomes in women with endometriosis and infertility.
-
Comparing different techniques to treat endometriosis
This study is testing different methods to treat endometriosis, like laser and heat techniques, to see which one works best for relieving pain in women who are already having surgery for the condition.
-
Complete colorectal deep infiltrating endometriosis surgery before IVF to improve fertility
This trial tests whether having complete surgery for colorectal deep infiltrating endometriosis before in vitro fertilization (IVF) helps women with endometriosis and infertility get pregnant.
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Postoperative Pain Trajectories After Endometriosis Surgery
This study tests how pain changes after endometriosis surgery and whether perioperative pain testing can predict who will have ongoing pain.
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Imaging endometriosis with a special PET tracer in adult women
This study tests whether a PET/CT scan using [18F]AlF-FAPI-74 can help detect endometriosis lesions in women who are planning laparoscopy.
-
Fiber supplement for digestive symptoms in endometriosis
A fiber-based supplement is being tested to see if it is safe and helps with gut and vaginal microbiomes and digestive symptoms in women with endometriosis.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.