Mapping the cellular landscape of endometriosis
Establishing an Endometriosis Transcriptomic Cell Atlas to Decipher the Pathophysiological Role of Stem Cells and Estrogens in the Disease
This study is trying to understand the differences between healthy tissue and endometriosis by looking at samples from women during their menstrual cycles to see how certain cells and hormones are involved in the condition.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 92 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | Female |
| Sponsor | University Hospital, Toulouse Academic / other |
| Locations | 1 site (Toulouse) |
| Trial ID | NCT06502548 on ClinicalTrials.gov |
What this trial studies
This study aims to explore the cellular diversity between normal endometrial tissue and endometriotic lesions by analyzing samples collected from women at different menstrual phases. It focuses on identifying potential stem cells and the immune environment that contribute to endometriosis, utilizing advanced techniques such as transcriptomics and imaging analysis. Additionally, the study will develop organoid models to investigate the role of estrogen signaling in women with and without endometriosis, providing insights into the disease's initiation and progression.
Who should consider this trial
Good fit: Ideal candidates include women aged 18 to 45 with stage III or IV endometriosis requiring surgery and healthy women undergoing tubal ligation or hysterectomy for benign reasons.
Not a fit: Patients with non-surgically treated endometriosis or those currently on hormonal treatment may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and targeted treatments for endometriosis and related infertility.
How similar studies have performed: While there have been studies exploring aspects of endometriosis, this approach combining transcriptomics and organoid models is relatively novel and untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients over 18 and under 45 years of age * Patients with multiple endometriosis sites (superficial, deep and endometriomas) with an indication for surgery to treat disabling painful symptoms and stage III or IV endometriosis in the context of infertility. * Healthy patients including those operated on between the ages of 18 and 45 for tubal ligation * Healthy patients operated on between the ages of 18 and 45 for hysterectomies for benign causes other than endometriosis or adenomyosis * Patients operated on strictly at the time of menstruation * Participants who have not been on hormonal treatment for 2 months * Participant having signed the free and informed consent form * Membership of a Social Security scheme or equivalent Exclusion Criteria: * Patients with endometriosis non-surgically treated * Patients with endometriosis receiving hormonal treatment at the time of surgery or having received hormonal treatment in the 2 months prior to surgery * Patients with adenomyosis only * Healthy non-endometriotic patients undergoing hysterectomy for infectious or malignant causes * Patients benefiting from a legal protection measure (guardianship, curatorship, safeguard of justice) * Patients with positive serology for human immunodeficiency virus (HIV), human T-lymphotropic virus (HTLV), hepatitis B (HBV) and hepatitis C (HCV)
Where this trial is running
Toulouse
- University Hospital Toulouse — Toulouse, France (Recruiting)
Study contacts
- Principal investigator: Elodie CHANTALAT, MD — University Hospital, Toulouse
- Study coordinator: Elodie CHANTALAT, MD
- Email: chantalat.e@chu-toulouse.fr
- Phone: 0561323953
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.