Endometriosis and future heart disease risk in women and girls
Official title: Systemic metabolomic dysregulation linking endometriosis to subsequent cardiovascular disease
Funded at Fred Hutchinson Cancer Center · NIH-11277615 · Data updated 2026-11-12
This NIH grant explores how endometriosis in girls and women is linked to higher risk of heart disease later in life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | July 15, 2026 |
| Project end | March 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $947,180 |
| NIH project number | 1R01HL183127-01 |
| Project ID | NIH-11277615 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adolescents and adults with endometriosis who can provide blood samples and participate in long-term follow-up.
✕Less likely to help
Patients without endometriosis may not directly benefit from this study.
What this research studies
If funded, researchers will study metabolic changes in people with endometriosis to understand why their risk of cardiovascular disease rises as they age. The project will track blood markers and other indicators from adolescence through adulthood to find links to future heart problems. By identifying specific pathways, the study aims to point to targets for prevention or treatment that could benefit patients with endometriosis. The work builds on preliminary findings that certain lipids and metabolites are higher in teens with endometriosis, suggesting a non-traditional route to CVD risk.
Why it matters
Potential benefit: The research could lead to earlier detection and new strategies to prevent heart disease for people with endometriosis.
How similar studies have gone: Previous work has linked endometriosis to higher CVD risk, but this project aims to uncover specific metabolic pathways in adolescence that contribute to that risk.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Sasamoto, Naoko — Fred Hutchinson Cancer Center
- Study coordinator: Sasamoto, Naoko
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.