How ovarian stimulation affects blood clot (fibrin) properties

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares thrombin generation and fibrinolysis parameters in women with infertility who are scheduled for ovarian hyperstimulation as part of assisted reproductive techniques. Blood samples will be taken around the stimulation period and analyzed for fibrin clot structure, thrombin formation, and clot lysis efficiency. Different ovarian stimulation protocols will be compared to determine their effects on coagulation and the efficiency of fibrinolysis. The aim is to see whether microclot formation could be linked to implantation problems and to inform protocol choice.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* infertility defined based on the WHO 2010 criteria

Exclusion Criteria:

* ovarian involvement
* oral contraceptives use within previous 3 months
* dienogest therapy within 3 months until ART
* thrombotic events in the medical history
* severe hypertension
* diabetes mellitus
* the presence of known VTE risk factors, including obesity, recent major surgery with prolonged immobilization or trauma,
* deficiency of antithrombin, protein C or protein S,
* antiphospholipid syndrome,
* known malignancy,
* any chronic inflammatory diseases (e.g. rheumatoid arthritis)
* advanced chronic renal disease (estimated glomerular filtration rate \[eGFR\] \<30 ml/min),
* international normalized ratio (INR) more than 1.2 at the day of blood draw
* pregnancy.

Where it's running

• Department of Gynecological Endocrinology Jagiellonian University Medical College
  Krakow, Małopolska, Poland Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.