Understanding how RPLP1 affects endometriosis and adenomyosis
Official title: Defining the role of RPLP1 in endometriosis and adenomyosis pathophysiology.
Funded at University of Kansas Medical Center · NIH-11434812 · Data updated 2026-11-12
A patient-focused look at how a ribosomal protein called RPLP1 may drive tissue changes in endometriosis and adenomyosis and what this could mean for future therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $662,769 |
| NIH project number | 1R01HD122901-01 |
| Project ID | NIH-11434812 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are women with diagnosed endometriosis and/or adenomyosis who may participate through tissue donation or future related studies.
✕Less likely to help
Patients without these conditions or those not contributing tissue samples in related steps may not benefit.
What this research studies
This project investigates why RPLP1 is overexpressed in endometriosis and adenomyosis tissues and how it influences cell behavior linked to disease, such as invasion and survival. The study will compare cellular features in diseased versus normal uterine tissues and explore how RFLP1 interacts with EMT-related markers like RGS1. Researchers will use cellular and tissue analyses to map how RPLP1 affects immune cell patterns and tissue remodeling in the uterus. The goal is to identify potential targets for treatments that could lessen pain and improve fertility for affected patients.
Why it matters
Potential benefit: If successful, the research could reveal new targets for therapies that reduce tissue invasion and balance immune responses, potentially easing symptoms and improving fertility for patients with these conditions.
How similar studies have gone: Some prior work has linked RPLP1 and EMT markers to disease-like processes, but direct roles in endometriosis/adenomyosis are still being explored.
Where this research is happening
-
University of Kansas Medical Center
Kansas City, United States Active
Researchers
- Principal investigator: Nothnick, Warren B — University of Kansas Medical Center
- Study coordinator: Nothnick, Warren B
Related research
Other NIH-funded projects on the same topics.
-
Molecular clues to endometriosis-related infertility
This grant explores how molecular changes in endometriosis contribute to infertility, with the aim of finding better ways to diagnose and treat the condition.
-
Hormonal Influences on Inflammation in Endometriosis
A study in adult women with endometriosis looks at how hormones and immune pathways interact to influence inflammation and symptoms.
-
How genes influence endometriosis in women of different racial and ethnic backgrounds
The team will compare genetic changes in tissue from women of various races who have endometriosis to find molecular targets for better treatments.
-
Quantum diamond sensor endoscopy to map iron in endometriosis
A tiny quantum sensor built into an endoscope will map iron in endometriosis lesions to help diagnose the disease noninvasively.
-
CXCR4 methylation in endometriosis and its role as an early biomarker and non-hormonal therapy target
This project explores how changes in CXCR4 gene regulation may help diagnose endometriosis earlier and point toward non-hormonal treatments for the condition.
-
Hormonal links to inflammation in endometriosis
A study to understand how hormones influence immune signals in endometriosis to help explain symptoms and identify potential targets for treatment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.