New [18F]-FES PET/CT imaging to detect and describe endometriosis lesions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants will undergo a preoperative [18F]-FES PET/CT scan in addition to standard MRI, with images compared to surgical and pathology findings to locate and characterize lesions. The study will correlate PET uptake with tissue estrogen receptor expression measured on surgical specimens and with patient-reported pain intensity. Enrollment includes symptomatic cases (VAS ≥ 4) and control patients treated surgically for infertility (VAS < 4), with imaging performed mid-cycle when possible. The approach aims to determine whether [18F]-FES PET/CT improves lesion detection and provides quantitative receptor information that could guide treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Cases:

\- Painful patients with a VAS ≥ 4 treated surgically for painful symptoms related to endometriosis;

Controls:

* Patient with a VAS \< 4 treated surgically for endometriosis in the context of infertility;
* Age \> 18 years;
* Patient who provided informed consent;
* Patients who underwent a preoperative MRI and were not contraindicated for \[18F\]-FES PET/CT;
* Patient who underwent surgery mid-cycle;
* Affiliation to a social security scheme

Exclusion Criteria:

* Patient treated for endometriosis without surgery;
* Pregnant patient
* Patient taking hormone therapy
* Menopausal patient
* Hypersensitivity to the active substance (Fluoroestradiol (18F)) or to any of the excipients
* Patient under legal protection
* Claustrophobic patient

Where it's running

• Toulouse, Rangueil Hospital
  Toulouse, France Recruiting

Study contacts

• Principal investigator: Ariane WEYL, MD — University Hospital, Toulouse
• Study coordinator: Ariane Weyl
• Email: weyl.a@chu-toulouse.fr
• Phone: 05 61 32 21 48

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Postoperative Pain Trajectories After Endometriosis Surgery

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• Imaging endometriosis with a special PET tracer in adult women

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• Fiber supplement for digestive symptoms in endometriosis

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• Atypical Endometriosis: Histology, Immunophenotype and Molecular Features

  Researchers will look at how endometriotic tissue that looks atypical under the microscope relates to clinical features and ultrasound findings to better separate benign from potentially atypical lesions.

  Recruiting Casa di Cura Dott. Pederzoli · Peschiera del Garda, Verona · NCT07816133

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.