Immune signals and regulatory T cells in migraine

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-site study enrolls women aged 18–50 in two main groups: those with specified autoimmune or inflammatory diagnoses (MS, SLE, RA, Crohn's disease, type 1 diabetes, or endometriosis) and those with migraine (at least four headache days per month). Participants provide blood samples that will be analyzed for cytokines, neuropeptides and regulatory T cell numbers/function. Results will compare immune marker patterns between groups and explore correlations with migraine frequency and characteristics. The protocol involves only blood sampling and laboratory assays, with no therapeutic intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* female
* 18 - 50 years of age
* at least 50 kg
* autoimmune/inflammatory disease groups : with a diagnosis of multiple sclerosis, systemic lupus erythematous, rheumatoid arthritis, Crohn's disease, type 1 diabetes or endometriosis
* migraine group : with a diagnosis of migraine with at least 4 headache days per month

Exclusion Criteria:

* BMI \< or = 17 ou \> or = 30kg/m²
* type 2 diabetes, immune deficit, other chronic autoimmune or inflammatory disease
* non-migraine headache, except for tension type headache of less than 4 days/month
* pregnancy, delivery, miscarriage, breast-feeding, participation in a medically assisted human reproduction program (ovary stimulation/hormone therapy) \< 3 months before blood sampling
* Menopause, hysterectomy, or bilateral oophorectomy
* Hormone therapy (besides contraception and treatment of endometriosis)
* bone marrow or solid organ transplant
* guardianship, curatorship, safeguard of justice or deprivation of liberty
* for patients : diagnosis of several autoimmune or inflammatory diseases
* for controls : diagnosis of an autoimmune or inflammatory disease
* for non-migraine participants : migraine

Where it's running

• CHU de Clermont-Ferrand - Service de Neurologie
  Clermont-Ferrand, Aura, France Recruiting

Study contacts

• Principal investigator: Xavier MOISSET — University Hospital, Clermont-Ferrand
• Study coordinator: Lise LACLAUTRE
• Email: promo_interne_drci@chu-clermontferrand.fr
• Phone: 334.73.754.963

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.