How hormones change inflammation in endometriosis
Hormonal Influences on Inflammation in Endometriosis
This project looks at how sex hormones alter immune and inflammatory processes in people with endometriosis to find clues for better treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11197620 on NIH RePORTER |
What this research studies
Researchers will compare large genetic datasets from people with endometriosis and related inflammatory conditions to find shared risk genes. They will analyze patient tissue using single-cell and spatial molecular techniques to see which immune cells and signals respond to hormones. By linking genetic signals to specific cell states and hormone responses, the team hopes to explain why lesions survive outside the uterus and cause pain or infertility.
Who could benefit from this research
Good fit: Ideal candidates are reproductive‑age people with diagnosed endometriosis who can provide tissue samples or genetic information for research.
Not a fit: People without endometriosis or those unable to provide clinical samples or genetic data are unlikely to gain direct benefit from this project.
Why it matters
Potential benefit: If successful, the work could identify new hormone‑sensitive immune targets that lead to therapies reducing pain and improving fertility for people with endometriosis.
How similar studies have performed: Genetic and single‑cell mapping approaches have revealed mechanisms in other inflammatory diseases and are promising for endometriosis, but translating those findings into treatments is still early.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Lawrenson, Kate — University of Texas Hlth Science Center
- Study coordinator: Lawrenson, Kate
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.