A new non-invasive test for diagnosing endometriosis in women facing infertility
Official title: Performance evaluation of a non-invasive menstrual test for endometriosis in infertility patients
Funded at Nextgenjane, INC. · NIH-11185524 · Data updated 2026-11-12
This study is working on a simple and non-invasive test using menstrual fluid to help diagnose endometriosis earlier, which could make it easier for women to get the care they need and improve their chances of having children.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nextgenjane, INC. NIH-funded |
| Lab location | 1 site (Oakland, UNITED STATES) |
| Project start | April 15, 2025 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $759,944 |
| NIH project number | 1R44HD118899-01 |
| Project ID | NIH-11185524 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women experiencing infertility who may have endometriosis.
✕Less likely to help
Patients who do not have infertility issues or those who have already been diagnosed with endometriosis may not benefit from this research.
What this research studies
This research focuses on developing a non-invasive menstrual test to diagnose endometriosis, a condition that often delays diagnosis and negatively impacts fertility. By utilizing menstrual fluid, which contains reproductive tissue, the study aims to create a reliable biomarker test that can be easily collected and transported to a laboratory. This approach seeks to provide earlier detection of endometriosis, potentially improving patient outcomes and reducing the need for invasive surgical procedures. The research is being conducted by NextGen Jane, Inc., which has already shown promising preliminary results with a genomic assay for endometriosis detection.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnoses of endometriosis, improving fertility outcomes for affected patients.
How similar studies have gone: While the approach of using menstrual fluid for diagnosis is innovative, similar non-invasive diagnostic methods for endometriosis have shown promise in preliminary studies.
Where this research is happening
-
Nextgenjane, INC.
Oakland, United States Active
Researchers
- Principal investigator: Gire, Stephen — Nextgenjane, INC.
- Study coordinator: Gire, Stephen
Related research
Other NIH-funded projects on the same topics.
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Molecular clues to endometriosis-related infertility
This grant explores how molecular changes in endometriosis contribute to infertility, with the aim of finding better ways to diagnose and treat the condition.
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Non-invasive menstrual biomarker test for endometriosis in infertility patients
A non-invasive test using menstrual fluid is being developed to help diagnose endometriosis in people dealing with infertility.
-
Hormonal Influences on Inflammation in Endometriosis
A study in adult women with endometriosis looks at how hormones and immune pathways interact to influence inflammation and symptoms.
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How genes influence endometriosis in women of different racial and ethnic backgrounds
The team will compare genetic changes in tissue from women of various races who have endometriosis to find molecular targets for better treatments.
-
Oral FSH receptor activator drugs to lower infertility treatment costs
A new oral drug approach aims to improve fertility treatments by using a small molecule that activates the FSH receptor, potentially making infertility care more affordable.
-
Prediction of ART outcomes for male factor infertility using single-molecule chromatin stenciling in sperm
A new test called sperm Fiber-seq is being developed to better predict how well ART will work for couples dealing with male-factor infertility.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.