Effect of GnRH Agonist on Endometriosis Cysts
Official title: Effect of GnRH Agonist Administration on Decreasing VAS, Estradiol, and Anti Mullerian Hormone in Endometriosis Cyst Patients
Run by Rumah Sakit Pusat Angkatan Darat Gatot Soebroto · NCT06525155 · Data updated 2026-11-12
This study tests if a new medication can help women aged 18 to 40 with endometriosis cysts feel less pain and have fewer side effects before and after surgery.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 40 Years |
| Sex | Women only |
| Enrollment | 32 (estimated) |
| Sponsor | Rumah Sakit Pusat Angkatan Darat Gatot Soebroto Academic / other |
| Locations | 1 site (Jakarta) |
| Status | Recruiting |
| Started | January 2, 2024 |
| Main results expected | February 2025 |
| Study ends | February 2025 |
| Registry record updated | November 25, 2024 |
| Trial ID | NCT06525155 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are females aged 18 to 40 diagnosed with endometriosis cysts who have regular menstrual cycles.
✕Probably not a fit
Patients who have used hormonal contraception or GnRH agonists in the last three months, or those with certain medical histories, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effectiveness of triptorelin embonate, a GnRH agonist, in treating endometriosis cysts in women aged 18 to 40. Participants will be divided into two groups, receiving either two doses before surgery and one after, or just one dose after surgery. The study will evaluate pain relief using a visual analogue scale and measure hormone levels at specified intervals. The goal is to determine if a longer dosing interval can improve patient compliance and reduce side effects.
Why it matters
Potential benefit: If successful, this treatment could provide a more effective and patient-friendly approach to managing endometriosis symptoms.
How similar studies have gone: Previous studies have indicated that extended dosing intervals of triptorelin may be effective, suggesting potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female subjects aged 18 to 40 years. * The subjects was diagnosed with endometriosis cysts. * Willing to participate in research and sign informed consent before all research-related activities begin. * Regular menstruation (within 25 - 35 day intervals) in the last 3 months before the study was conducted. Exclusion Criteria: * The patient used hormonal contraception in the last 3 months prior to the study. * Using a GnRH agonist within the past 3 months. * Using the hormone progesterone within the last 3 months * Pregnancy, breastfeeding females * History of osteoporosis * History of blood clotting disorders * History of heart and blood vessel disorders
Where it's running
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Department of Obstetrics and Gynecology Central Army Hospital Gatot Soebroto
Jakarta, Indonesia Recruiting
Study contacts
- Principal investigator: Surya A Pramono, Sp.OG., Subsp.FER, MD — Rumah Sakit Pusat Angkatan Darat Gatot Soebroto
- Study coordinator: Surya A Pramono, Sp.OG., Subsp.FER, MD
- Email: suryaadipramono230781@gmail.com
- Phone: +6282145122104
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Comparing different techniques to treat endometriosis
This study is testing different methods to treat endometriosis, like laser and heat techniques, to see which one works best for relieving pain in women who are already having surgery for the condition.
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Postoperative Pain Trajectories After Endometriosis Surgery
This study tests how pain changes after endometriosis surgery and whether perioperative pain testing can predict who will have ongoing pain.
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Imaging endometriosis with a special PET tracer in adult women
This study tests whether a PET/CT scan using [18F]AlF-FAPI-74 can help detect endometriosis lesions in women who are planning laparoscopy.
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Fiber supplement for digestive symptoms in endometriosis
A fiber-based supplement is being tested to see if it is safe and helps with gut and vaginal microbiomes and digestive symptoms in women with endometriosis.
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Stellate ganglion block and dexmedetomidine for better sleep after gynecologic laparoscopy
The study tests whether giving a preoperative stellate ganglion block plus intraoperative dexmedetomidine improves sleep after laparoscopic gynecologic surgery in women.
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Atypical Endometriosis: Histology, Immunophenotype and Molecular Features
Researchers will look at how endometriotic tissue that looks atypical under the microscope relates to clinical features and ultrasound findings to better separate benign from potentially atypical lesions.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.