Understanding how genes shape endometriosis severity using single-cell multi-omics
Official title: Disentangling the genetic mechanisms of endometriosis severity with single-cell multi-omics
Funded at University of Texas Hlth Science Center · NIH-11324620 · Data updated 2026-11-12
Researchers will map how genetic and epigenetic factors contribute to different severities of endometriosis to help improve diagnosis and future treatments for people living with the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | September 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $691,810 |
| NIH project number | 5R01HD114855-03 |
| Project ID | NIH-11324620 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with endometriosis across different disease stages who have consented to participate in genomic and epigenomic analyses.
✕Less likely to help
Patients not represented in the study cohort or those without endometriosis may not directly benefit.
What this research studies
This project looks at endometriosis, a painful and often fertility‑related condition, by studying how gene regulation changes across individual cells in high‑ and low‑severity cases. Using advanced single‑cell epigenomics and multi-omics approaches, the team will profile landscapes of gene regulation and identify allele‑specific effects that differ by disease stage. They will also build genetic predictors that could forecast outcomes for patients based on their unique biology. The study leverages a large well‑annotated cohort to connect molecular patterns with clinical features, with the aim of revealing mechanisms that drive disease severity. The ultimate goal is to lay groundwork for personalized strategies in diagnosis and management tied to a patient’s molecular profile.
Why it matters
Potential benefit: If successful, the findings could lead to better stage-specific understandings of endometriosis and pave the way for personalized diagnostics and targeted therapies.
How similar studies have gone: Previous work has mapped gene expression in endometriosis and endometrioma, with growing evidence that molecular patterns relate to disease stage.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Lawrenson, Kate — University of Texas Hlth Science Center
- Study coordinator: Lawrenson, Kate
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.