Understanding subtypes of endometriosis-linked ovarian cancer
Relating Molecular Subgroups of Endometriosis-Associated Ovarian Cancers to Survival and Risk
['FUNDING_R01'] · MAYO CLINIC ROCHESTER · NIH-11312707
This project looks at genetic subgroups of two endometriosis-associated ovarian cancers to find connections with survival and factors like smoking and body weight for people with these cancers.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11312707 on ClinicalTrials.gov |
What this research studies
Researchers are analyzing the molecular and genomic profiles of roughly 1,100 endometrioid and clear cell ovarian tumors that are often linked to endometriosis. They will combine tumor genetics with clinical data such as survival time, smoking history, and body mass index to see if distinct subgroups explain differences in outcomes and risk. The team builds on smaller genomic analyses that suggested some subgroups have much worse survival and different risk factor links. Results aim to define clear molecular groups that could guide future personalized treatment approaches.
Who could benefit from this research
Good fit: People diagnosed with endometrioid or clear cell ovarian cancer who can provide clinical records and tumor tissue or are treated at participating centers would be the best fit.
Not a fit: Patients with other ovarian cancer types (for example high-grade serous) or those without available tumor tissue are unlikely to get direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could help identify patients at higher risk and point to more tailored treatment options based on tumor subtype.
How similar studies have performed: Preliminary genomic studies of smaller groups (hundreds of tumors) have shown promising subgroup links to survival and risk factors, but large-scale confirmation is still new.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOODE, ELLEN L. — MAYO CLINIC ROCHESTER
- Study coordinator: GOODE, ELLEN L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Biology, Cancers