Understanding subtypes of endometriosis-linked ovarian cancer
Official title: Relating Molecular Subgroups of Endometriosis-Associated Ovarian Cancers to Survival and Risk
Funded at Mayo Clinic Rochester · NIH-11312707 · Data updated 2026-11-12
This project looks at genetic subgroups of two endometriosis-associated ovarian cancers to find connections with survival and factors like smoking and body weight for people with these cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | January 13, 2021 |
| Project end | December 31, 2026 |
| Funding year | 2026 |
| Award (this year) | $404,487 |
| NIH project number | 5R01CA248288-06 |
| Project ID | NIH-11312707 on NIH RePORTER |
Who could benefit from this research
✓Could help
People diagnosed with endometrioid or clear cell ovarian cancer who can provide clinical records and tumor tissue or are treated at participating centers would be the best fit.
✕Less likely to help
Patients with other ovarian cancer types (for example high-grade serous) or those without available tumor tissue are unlikely to get direct benefit from this project.
What this research studies
Researchers are analyzing the molecular and genomic profiles of roughly 1,100 endometrioid and clear cell ovarian tumors that are often linked to endometriosis. They will combine tumor genetics with clinical data such as survival time, smoking history, and body mass index to see if distinct subgroups explain differences in outcomes and risk. The team builds on smaller genomic analyses that suggested some subgroups have much worse survival and different risk factor links. Results aim to define clear molecular groups that could guide future personalized treatment approaches.
Why it matters
Potential benefit: If successful, this work could help identify patients at higher risk and point to more tailored treatment options based on tumor subtype.
How similar studies have gone: Preliminary genomic studies of smaller groups (hundreds of tumors) have shown promising subgroup links to survival and risk factors, but large-scale confirmation is still new.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Goode, Ellen L. — Mayo Clinic Rochester
- Study coordinator: Goode, Ellen L.
Related research
Other NIH-funded projects on the same topics.
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Molecular clues to endometriosis-related infertility
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Hormonal Influences on Inflammation in Endometriosis
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How genes influence endometriosis in women of different racial and ethnic backgrounds
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Quantum diamond sensor endoscopy to map iron in endometriosis
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Understanding how RPLP1 affects endometriosis and adenomyosis
A patient-focused look at how a ribosomal protein called RPLP1 may drive tissue changes in endometriosis and adenomyosis and what this could mean for future therapies.
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CXCR4 methylation in endometriosis and its role as an early biomarker and non-hormonal therapy target
This project explores how changes in CXCR4 gene regulation may help diagnose endometriosis earlier and point toward non-hormonal treatments for the condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.