Analyzing the microbiome in women with endometriosis and unexplained infertility

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to investigate the gut, peritoneal, and uterine microbiomes in women undergoing laparoscopy for endometriosis or idiopathic infertility. It will analyze the correlation between microbiome composition and the severity of endometriosis, as well as the relationship between microbiome profiles and symptoms such as pain and infertility. Additionally, the study will assess the quality of life in participants using the SF-36 questionnaire, comparing results between the two groups. The methodology involves Next Generation Sequencing (NGS) to provide detailed insights into the microbiome's role in these conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* age 18-45 years
* indications for surgical treatment of endometriosis by laparoscopy and/or indications for invasive diagnostics by laparoscopy due to idiopathic infertility.

Exclusion Criteria:

* abdominal surgeries performed within 6 months prior hospitalisation
* active infection of the genital tract
* inflammatory bowel disease
* antibiotic therapy and use of probiotics within 3 months before surgery

Where it's running

• Jagiellonian University Medical College, Department of Gynecology and Obstetrics
  Krakow, Poland Recruiting

Study contacts

• Study coordinator: Iwona M. Gawron, Ph.D.
• Email: iwona.gawron@uj.edu.pl
• Phone: +48 124248571

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Comparing different techniques to treat endometriosis

  This study is testing different methods to treat endometriosis, like laser and heat techniques, to see which one works best for relieving pain in women who are already having surgery for the condition.

  Recruiting TriHealth Inc. · Cincinnati, Ohio · NCT06414083

• Postoperative Pain Trajectories After Endometriosis Surgery

  This study tests how pain changes after endometriosis surgery and whether perioperative pain testing can predict who will have ongoing pain.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07882498

• Imaging endometriosis with a special PET tracer in adult women

  This study tests whether a PET/CT scan using [18F]AlF-FAPI-74 can help detect endometriosis lesions in women who are planning laparoscopy.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT07876648

• Fiber supplement for digestive symptoms in endometriosis

  A fiber-based supplement is being tested to see if it is safe and helps with gut and vaginal microbiomes and digestive symptoms in women with endometriosis.

  Recruiting LOAM Science · San Francisco, California · NCT07875062

• Stellate ganglion block and dexmedetomidine for better sleep after gynecologic laparoscopy

  The study tests whether giving a preoperative stellate ganglion block plus intraoperative dexmedetomidine improves sleep after laparoscopic gynecologic surgery in women.

  Recruiting The Second People's Hospital of Huai'an · Huai'an, Jiangsu · NCT07860203

• Atypical Endometriosis: Histology, Immunophenotype and Molecular Features

  Researchers will look at how endometriotic tissue that looks atypical under the microscope relates to clinical features and ultrasound findings to better separate benign from potentially atypical lesions.

  Recruiting Casa di Cura Dott. Pederzoli · Peschiera del Garda, Verona · NCT07816133

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.