Menstrual stem cells in endometriosis
Official title: Study of the Role of Menstrual Blood-derived Stem Cells and the Immune Environment in Endometriosis
Run by University Rovira i Virgili · NCT07578480 · Data updated 2026-11-12
This project will see if menstrual blood stem cells from women with endometriosis behave differently at the molecular and immune levels compared with cells from women without endometriosis.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 40 (estimated) |
| Sponsor | University Rovira i Virgili Academic / other |
| Locations | 2 sites (Reus, Tarragona and 1 other locations) |
| Status | Recruiting |
| Started | April 2026 |
| Main results expected | October 2027 |
| Study ends | April 2028 |
| Registry record updated | May 11, 2026 |
| Trial ID | NCT07578480 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women aged 18–45 who can provide menstrual blood and either have a clinical/ecographic diagnosis of endometriosis or serve as controls without endometriosis, and who have not used hormonal, immunosuppressive, or antibiotic treatments in the prior 3 months are ideal candidates.
✕Probably not a fit
People under 18 or over 45, pregnant or breastfeeding women, those with active pelvic inflammatory or autoimmune disease, recent hormonal/immunosuppressive/antibiotic use, insufficient menstrual flow, active gynecological cancer, or positive HIV/HPV tests are unlikely to be eligible or to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Researchers will collect menstrual blood from women aged 18–45, isolate menstrual blood-derived stem cells (MenSCs) and perform in vitro functional, molecular and immunological analyses. Findings in MenSCs will be validated against endometrial tissue and endometrioma samples when available. Results will be correlated with clinical features to identify patterns linked to disease severity and symptoms. The study is observational and does not involve experimental treatments.
Why it matters
Potential benefit: If successful, this work could reveal cellular mechanisms that point to new biomarkers or therapeutic targets for endometriosis.
How similar studies have gone: A few smaller studies have characterized menstrual stem cells in gynecologic conditions, but broad molecular and immune profiling with direct tissue validation remains relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18-45 years. * Endometriosis group: Women with clinical and/or ecographical diagnostic of endometriosis. * Control group: Women with the endometriosis diagnosis. Exclusion Criteria: * \<18 years or \>45 years. * Pregnancy or lactation. * Diagnosis of prior chronic pelvic inflammatory or autoimmune disease. * History of active gynecological cancer. * Positive for human immunodeficiency virus (HIV) or human papillomavirus (HPV). * Hormonal therapy use in the previous 3 months. * Use of immunosuppressants or corticosteroids in the previous 3 months. * Systemic antibiotics use in the previous 3 months. * Insufficient menstrual flow to allow the MenSCs isolation.
Where it's running
-
Hospital Universitari Joan XXIII
Tarragona, Tarragona, Spain Recruiting -
Universitat Rovira i Virgili. Facultat de Medicina i Ciències de la Salut
Reus, Tarragona, Spain Active not recruiting
Study contacts
- Study coordinator: Dr. Francisco Algaba-Chueca
- Email: francisco.algaba@urv.cat
- Phone: +34623966066
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Comparing different techniques to treat endometriosis
This study is testing different methods to treat endometriosis, like laser and heat techniques, to see which one works best for relieving pain in women who are already having surgery for the condition.
-
Postoperative Pain Trajectories After Endometriosis Surgery
This study tests how pain changes after endometriosis surgery and whether perioperative pain testing can predict who will have ongoing pain.
-
Imaging endometriosis with a special PET tracer in adult women
This study tests whether a PET/CT scan using [18F]AlF-FAPI-74 can help detect endometriosis lesions in women who are planning laparoscopy.
-
Fiber supplement for digestive symptoms in endometriosis
A fiber-based supplement is being tested to see if it is safe and helps with gut and vaginal microbiomes and digestive symptoms in women with endometriosis.
-
Stellate ganglion block and dexmedetomidine for better sleep after gynecologic laparoscopy
The study tests whether giving a preoperative stellate ganglion block plus intraoperative dexmedetomidine improves sleep after laparoscopic gynecologic surgery in women.
-
Atypical Endometriosis: Histology, Immunophenotype and Molecular Features
Researchers will look at how endometriotic tissue that looks atypical under the microscope relates to clinical features and ultrasound findings to better separate benign from potentially atypical lesions.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.