Condition

Dysmenorrhea clinical trials and research

• 15Clinical trials
• 9NIH research projects
• 6Countries

Newest Dysmenorrhea clinical trials

All recruiting trials (15)

• Osteopathic Manipulative Treatment for Dysmenorrhea Symptoms

  This pilot study tests whether a targeted OMT session before the next period can reduce pain and other dysmenorrhea symptoms in female university community members.

  Recruiting Western University of Health Sciences · Pomona, California · NCT07849140

• Diaphragm-Pelvic Floor Training for Young Women with Menstrual Pain

  A randomized trial tests whether Diaphragm-Pelvic Floor Synergy training can reduce menstrual pain and improve quality of life in university-aged women with primary dysmenorrhea.

  Recruiting Riphah International University · Islamabad, Punjab Province · NCT07754305

• Samphire Guided Care for Wellbeing at Work

  This study tests a 12-week digital program with at-home neuromodulation to see if it helps women with menstrual or perimenopausal symptoms feel better at work and in daily life.

  Recruiting Samphire Group, Inc. · San Francisco, California · NCT07679074

• Aerobic Exercise vs. Jacobson’s Relaxation for Primary Dysmenorrhea

  This study tests whether aerobic exercise or Jacobson’s progressive relaxation can help reduce pain and fatigue and improve quality of life for young women with primary dysmenorrhea.

  Recruiting Riphah International University · Okāra, Punjab Province · NCT07628452

• Sacral release versus lumbar mobilization for period cramps in teens.

  This will test whether sacral release or lumbar mobilization works better to reduce menstrual pain, lessen symptoms, and improve quality of life in adolescent girls with primary dysmenorrhea.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT07576231

• IV magnesium for acute menstrual cramp pain

  This trial will test whether a single IV dose of magnesium sulfate relieves severe menstrual cramp pain in women 18–35 better than IV dexketoprofen.

  Recruiting Gaziosmanpasa Research and Education Hospital · Gaziosmanpaşa, Outside of the US · NCT07248540

• How pelvic organ pain affects muscles and the automatic nervous system in women with painful periods

  We will test whether women with painful periods show bigger muscle and automatic nervous system (heart-rate variability) responses to a brief pelvic pain stimulus than women without painful periods.

  Recruiting Azusa Pacific University · Azusa, California · NCT07209566

• Good pain consultation for endometriosis

  This trial will test whether adding a 'good pain consultation' with early biopsychosocial pain education to usual care helps biological women with endometriosis manage pain and improve quality of life.

  Recruiting Sorlandet Hospital HF · Kristiansand, Agder · NCT07205614

• Doppler-guided angiopuncture for menstrual pain

  This test tries Doppler ultrasound-guided angiopuncture to reduce period pain in people with primary dysmenorrhea.

  Recruiting City University of Hong Kong · Changchun · NCT07176910

• Using NSAIDs to treat menstrual pain and prevent chronic pelvic pain

  This study is testing if taking naproxen sodium can help young adults with painful periods feel better and possibly prevent long-term pelvic pain.

  Recruiting Phase 4 Endeavor Health · Evanston, Illinois · NCT06861920

• Using distraction techniques to reduce pain during injections in adolescents with menstrual pain

  This study tests if distraction techniques like the Helfer Skin Tap Technique and ShotBlocker can help reduce pain during injections for teenagers who have menstrual pain.

  Recruiting Ondokuz Mayıs University · Samsun · NCT06842329

• Using TENS to relieve menstrual pain in women

  This study is testing if a device that sends gentle electrical pulses can help women with severe menstrual pain feel better.

  Recruiting Osmaniye Korkut Ata University · Osmaniye · NCT06741059

• Cognitive exercise therapy and yoga for period pain in teen girls

  This study will test whether cognitive exercise therapy or yoga can reduce menstrual pain and improve function in adolescent girls with primary dysmenorrhea.

  Recruiting Acibadem University · Istanbul, Ataşehir · NCT06398990

• Electroacupuncture for menstrual pain from adenomyosis

  This trial will try electroacupuncture to reduce menstrual pain in women with adenomyosis-related dysmenorrhea.

  Recruiting Guang'anmen Hospital of China Academy of Chinese Medical Sciences · Beijing · NCT06364592

• Understanding how period pain in adolescents may lead to chronic pain

  This study looks at how period pain in young women aged 11 to 20 might lead to long-term pain problems later on.

  Recruiting University of Oxford · Oxford, Oxfordshire · NCT06353789

NIH-funded research (9)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Decoding Dysmenorrhea: Longitudinal Pain Phenotypes in Adolescents and Young Adults

  A study on how menstrual pain develops over time in teenagers and young adults, exploring brain and behavior to understand why some have ongoing pain.

  NIH research Mclean Hospital · Belmont, United States · NIH-11447102

• Gut microbiome and multisensory sensitivity in teen menstrual pain

  A study in adolescent girls with moderate-to-severe menstrual pain will explore how gut bacteria relate to their pain and sensitivity to different senses.

  NIH research Mclean Hospital · Belmont, United States · NIH-11438140

• AI-powered, person-centered chatbot to help manage menstrual pain

  A patient-friendly AI chatbot called PeriodPal will provide evidence-based, personalized tips to help manage dysmenorrhea and reduce days missed from work or school.

  NIH research University of Arizona · Tucson, United States · NIH-11436001

• Vaginal microbiome and bodily signals linked to menstrual pain phenotypes

  This research will look at how the vaginal microbiome, inflammatory signals, hormones, and natural metabolites relate to different patterns of menstrual pain in diverse teens and young women.

  NIH research University of Arizona · Tucson, United States · NIH-11333329

• Investigating the role of vaginal microbiome in menstrual pain

  This study is looking at how the bacteria in the vagina might influence menstrual pain, or dysmenorrhea, in women aged 14-39, to help find better ways to treat those who experience different levels of pain during their periods.

  NIH research University of Arizona · Tucson, United States · NIH-11129803

• Understanding how menstrual pain can lead to chronic pelvic pain

  This study is looking at how painful periods might lead to long-term pelvic pain and how inflammation and nerve changes play a role, so we can find better ways to help women manage their pain and prevent it from getting worse.

  NIH research Endeavor Health Clinical Operations · Evanston, United States · NIH-11023728

• A home device to treat menstrual pain

  This study is testing a handy device called the SoleStim that helps relieve menstrual cramps for people who find that regular pain medications don’t work well for them, so they can feel better and manage their symptoms at home.

  NIH research Theranova, LLC · San Francisco, United States · NIH-10916979

• Understanding the causes of uterine pain to improve treatment for menstrual cramps

  This study is looking at how menstrual cramps happen and what causes the pain, using special MRI tools to see what's going on in the uterus during those painful times, with the hope of finding better treatments for women who experience severe cramps.

  NIH research Endeavor Health Clinical Operations · Evanston, United States · NIH-10692599

• Understanding menstrual pain and its effects on adolescent girls

  This study is looking at menstrual pain in girls aged 14-18 to find out what might predict if they will develop long-lasting pain, using tests and brain scans to understand how their bodies handle pain, with the hope of improving treatment options in the future.

  NIH research Mclean Hospital · Belmont, United States · NIH-10624359

Related topics

Quick answers

How many Dysmenorrhea clinical trials are recruiting right now?

15, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (4 trials), Turkey (Türkiye) (4 trials), Pakistan (3 trials), China (2 trials), Norway (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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