Understanding pain in patients with endometriosis and pelvic pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify factors contributing to chronic pelvic pain in patients with and without endometriosis. It will assess changes in pain and hormone levels following endometriosis lesion removal surgery. Participants will complete questionnaires and undergo psychophysical assessments to evaluate their pain responses. Additionally, blood, urine, and saliva samples will be collected to explore hormonal and immune factors related to pain.

Why it matters

Who can join: the full rules

Inclusion criteria:

* Patients with pelvic pain with and without endometriosis scheduled for an operative laparoscopic surgery for endometriosis diagnosis and/or treatment
* Age 12-45
* Females

Exclusion criteria:

* Pregnancy
* Planned hysterectomy or oophorectomy
* Co-occurring vaginismus and/or vulvodynia
* For patients aged 12-17 not having a parent/legal guardian willing to sign the consent and answer surveys about their child's health

Where it's running

• Washington University School of Medicine
  St Louis, Missouri, United States Recruiting

Study contacts

• Principal investigator: Hadas Nahman-Averbuch, PhD — Washington University School of Medicine
• Study coordinator: Alana McMichael, MA
• Email: painlab@wustl.edu
• Phone: 314-273-6194

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Personalized Exercise Recommendations for Chronic Pelvic Pain

  This study tests if an AI-powered, personalized exercise plan can help people with chronic pelvic pain see if tailored workouts work better than standard guidance.

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• Samphire Guided Care for Wellbeing at Work

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  Recruiting Samphire Group, Inc. · San Francisco, California · NCT07679074

• Electroacupuncture for pelvic pain in women with suspected endometriosis

  This study tests whether a series of electroacupuncture sessions can reduce pelvic pain in women awaiting diagnostic laparoscopy for suspected endometriosis.

  Recruiting St. Olavs Hospital · Trondheim · NCT07305025

• Franco-European Institute of Endometriosis long-term outcomes cohort

  This cohort will follow women with confirmed pelvic endometriosis to see if different medical and surgical treatments lead to better long-term symptoms, quality of life, recurrence rates, and fertility outcomes.

  Recruiting Clinique Tivoli Ducos · Bordeaux · NCT07243587

• Estradiol-linked inflammation and nerve sensitization in endometriosis pelvic pain treated with relugolix

  This study will try relugolix combination therapy to see if it reduces pelvic pain, inflammation, and pain sensitivity in premenopausal women with moderate-to-severe endometriosis-related pelvic pain.

  Recruiting Phase 3 University of Michigan · Ann Arbor, Michigan · NCT07100782

• Group care program for treating endometriosis-related pain

  This study is testing a new group care program called PEEPS to see if it can help people aged 18 to 48 with endometriosis-related pain feel better compared to those who just get regular support.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT06549985

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.