Hormonal links to inflammation in endometriosis
Official title: Hormonal Influences on Inflammation in Endometriosis
Funded at University of Texas Hlth Science Center · NIH-11419789 · Data updated 2026-11-12
A study to understand how hormones influence immune signals in endometriosis to help explain symptoms and identify potential targets for treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | September 25, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $288,880 |
| NIH project number | 5R01HG013258-03 |
| Project ID | NIH-11419789 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adult women with endometriosis or at risk for inflammatory conditions related to endometriosis may be eligible for future studies or follow-up investigations.
✕Less likely to help
Some participants may not directly benefit if their contribution does not lead to a new therapy or if their specific genetic profile differs from those driving the findings.
What this research studies
This project looks at how hormonal signals interact with the immune system to drive endometriosis, using large genetic datasets and advanced single-cell analysis. Researchers will map shared risk genes between endometriosis and inflammatory conditions and C taditionally examine how these signals manifest in individual cells within affected tissues. The goal is to build a clearer picture of why endometriosis happens and why symptoms vary among patients, with an eye toward future therapies. Participation would involve contributing to genetic or tissue studies and consenting to potential future use of samples if applicable.
Why it matters
Potential benefit: If successful, the work could reveal new molecular targets and pathways for therapies that alleviate symptoms and improve quality of life for people with endometriosis.
How similar studies have gone: Previous studies have linked endometriosis to inflammation and hormonal pathways, with ongoing research suggesting shared genetic factors across inflammatory diseases.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Lawrenson, Kate — University of Texas Hlth Science Center
- Study coordinator: Lawrenson, Kate
Related research
Other NIH-funded projects on the same topics.
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Molecular clues to endometriosis-related infertility
This grant explores how molecular changes in endometriosis contribute to infertility, with the aim of finding better ways to diagnose and treat the condition.
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Hormonal Influences on Inflammation in Endometriosis
A study in adult women with endometriosis looks at how hormones and immune pathways interact to influence inflammation and symptoms.
-
How genes influence endometriosis in women of different racial and ethnic backgrounds
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Quantum diamond sensor endoscopy to map iron in endometriosis
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Understanding how RPLP1 affects endometriosis and adenomyosis
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CXCR4 methylation in endometriosis and its role as an early biomarker and non-hormonal therapy target
This project explores how changes in CXCR4 gene regulation may help diagnose endometriosis earlier and point toward non-hormonal treatments for the condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.