Endometriosis Steroid Profile and Biomarker Discovery
Official title: STERONLINE: Steroidome and Exposome of Endometriosis Single-center Case-control Study
Run by Nantes University Hospital · NCT06820450 · Data updated 2026-11-12
This study tests a new method to map how steroids are processed in people with and without endometriosis by collecting blood, urine, and vaginal samples to find biomarkers related to the disease.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 135 (estimated) |
| Sponsor | Nantes University Hospital Academic / other |
| Locations | 1 site (Nantes) |
| Status | Recruiting |
| Started | July 1, 2025 |
| Main results expected | July 1, 2027 |
| Study ends | July 1, 2027 |
| Registry record updated | June 24, 2026 |
| Trial ID | NCT06820450 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women aged 18 to 45 who can consent in French, are insured, and are either without signs of endometriosis or newly diagnosed with deep endometriosis within 12 months.
✕Probably not a fit
Women with pregnancy, other hormone-related conditions, acute infection, or those outside the 18-45 age range may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to develop an LC-HRMS-based steroidomics method to characterize estrogen metabolism and related steroids in endometriosis. It will first optimize a targeted and non-targeted analytical workflow in serum and urine, then apply it to a case-control cohort of women with deep endometriosis and controls. The study will compare steroid profiles across groups and evaluate how well these profiles distinguish endometriosis. Non-invasive biomarker discovery could support earlier diagnosis and personalized management strategies. The project is led by Nantes University Hospital with participation from CHU de Nantes in France.
Why it matters
Potential benefit: If successful, the approach could enable non-invasive biomarkers for earlier diagnosis and more tailored treatment strategies for endometriosis.
How similar studies have gone: Previous research in steroidomics and endometriosis has shown potential for biomarker discovery, but this exact approach is exploratory and aims to expand existing findings.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women aged 18 to 45 * Free, informed and written consent from the patient to participate in the study * Good understanding of the French language * Patient affiliated to or benefiting from a social security or similar scheme Specific inclusion criteria for each group: Group 1. Controls. * Women with no laparoscopically confirmed signs suggestive of deep endometriosis. * No clinico-biological criteria in favour of a diagnosis of endometriotic disease, nor any radiological signs (ultrasound or MRI) suggestive of endometriosis. Group 2. Cases of deep endometriosis. * Newly diagnosed women (less than 12 months). * Severe, deep endometriotic pathology with surgical indication (clinical examination, imaging tests, pre-operative findings). Exclusion Criteria: * Intercurrent diagnosis of pregnancy. * Presence of other hormone-dependent pathologies (e.g. breast cancer, PCOS). * Acute infection.
Where it's running
-
CHU de Nantes
Nantes, France Recruiting
Study contacts
- Study coordinator: Stéphane PLOTEAU, PU-PH
- Email: Stéphane.ploteau@chu-nantes.fr
- Phone: 02.40.08.76.84
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Comparing different techniques to treat endometriosis
This study is testing different methods to treat endometriosis, like laser and heat techniques, to see which one works best for relieving pain in women who are already having surgery for the condition.
-
Postoperative Pain Trajectories After Endometriosis Surgery
This study tests how pain changes after endometriosis surgery and whether perioperative pain testing can predict who will have ongoing pain.
-
Imaging endometriosis with a special PET tracer in adult women
This study tests whether a PET/CT scan using [18F]AlF-FAPI-74 can help detect endometriosis lesions in women who are planning laparoscopy.
-
Fiber supplement for digestive symptoms in endometriosis
A fiber-based supplement is being tested to see if it is safe and helps with gut and vaginal microbiomes and digestive symptoms in women with endometriosis.
-
Stellate ganglion block and dexmedetomidine for better sleep after gynecologic laparoscopy
The study tests whether giving a preoperative stellate ganglion block plus intraoperative dexmedetomidine improves sleep after laparoscopic gynecologic surgery in women.
-
Atypical Endometriosis: Histology, Immunophenotype and Molecular Features
Researchers will look at how endometriotic tissue that looks atypical under the microscope relates to clinical features and ultrasound findings to better separate benign from potentially atypical lesions.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.