Investigating pain and hormone levels in migraine and endometriosis patients
Official title: Mechanisms Underlying Endometriosis and Migraine Comorbidity
Run by Washington University School of Medicine · NCT06785129 · Data updated 2026-11-12
This study is trying to see how pain responses and hormone levels differ in people with migraines, endometriosis, both conditions, and healthy individuals.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 12 Years to 45 Years |
| Sex | Women only |
| Enrollment | 120 (estimated) |
| Sponsor | Washington University School of Medicine Academic / other |
| Locations | 1 site (St Louis, Missouri) |
| Status | Recruiting |
| Started | February 12, 2025 |
| Main results expected | January 1, 2028 |
| Study ends | January 1, 2030 |
| Registry record updated | July 13, 2026 |
| Trial ID | NCT06785129 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals aged 12-45 with diagnosed migraine, endometriosis, or both, as well as healthy controls without chronic pain.
✕Probably not a fit
Patients who are pregnant, breastfeeding, or have certain psychiatric or neurological conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the differences in experimental pain responses and sex hormone levels among individuals with migraine, endometriosis, both conditions, and healthy controls. Participants will be recruited from various clinics and will undergo a comprehensive assessment involving surveys, psychophysical tests, and hormone sample collection. The study will utilize electronic consent processes and will include a diverse range of questionnaires to gather demographic and health-related information. The goal is to better understand the interplay between these conditions and pain perception.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of pain in patients with migraine and endometriosis.
How similar studies have gone: While there have been studies on pain and hormonal interactions, this specific approach combining these conditions in an observational format is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients with diagnosed endometriosis, migraine, or both endometriosis and migraine 2. Healthy control subjects with no history of chronic pain 3. Age 12-45 4. Assigned female sex at birth Exclusion Criteria: 1. Pregnancy or breastfeeding 2. Presence of prolactinoma 3. Presence of psychiatric, neurological, endocrinological and/or developmental conditions and taking medications for these conditions 4. Current use of dopamine agonist or SSRI medications 5. For patients aged 12-17 not having a parent/legal guardian willing to sign the consent and answer surveys about their child's health
Where it's running
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Washington University School of Medicine
St Louis, Missouri, United States Recruiting
Study contacts
- Principal investigator: Hadas Nahman-Averbuch, PhD — Washington University School of Medicine
- Study coordinator: Alana McMichael, MA
- Email: painlab@wustl.edu
- Phone: 314-273-6194
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.