Investigating pain and hormone levels in migraine and endometriosis patients
Mechanisms Underlying Endometriosis and Migraine Comorbidity
This study is trying to see how pain responses and hormone levels differ in people with migraines, endometriosis, both conditions, and healthy individuals.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 120 (estimated) |
| Ages | 12 Years to 45 Years |
| Sex | Female |
| Sponsor | Washington University School of Medicine Academic / other |
| Locations | 1 site (St Louis, Missouri) |
| Trial ID | NCT06785129 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the differences in experimental pain responses and sex hormone levels among individuals with migraine, endometriosis, both conditions, and healthy controls. Participants will be recruited from various clinics and will undergo a comprehensive assessment involving surveys, psychophysical tests, and hormone sample collection. The study will utilize electronic consent processes and will include a diverse range of questionnaires to gather demographic and health-related information. The goal is to better understand the interplay between these conditions and pain perception.
Who should consider this trial
Good fit: Ideal candidates include individuals aged 12-45 with diagnosed migraine, endometriosis, or both, as well as healthy controls without chronic pain.
Not a fit: Patients who are pregnant, breastfeeding, or have certain psychiatric or neurological conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of pain in patients with migraine and endometriosis.
How similar studies have performed: While there have been studies on pain and hormonal interactions, this specific approach combining these conditions in an observational format is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients with diagnosed endometriosis, migraine, or both endometriosis and migraine 2. Healthy control subjects with no history of chronic pain 3. Age 12-45 4. Assigned female sex at birth Exclusion Criteria: 1. Pregnancy or breastfeeding 2. Presence of prolactinoma 3. Presence of psychiatric, neurological, endocrinological and/or developmental conditions and taking medications for these conditions 4. Current use of dopamine agonist or SSRI medications 5. For patients aged 12-17 not having a parent/legal guardian willing to sign the consent and answer surveys about their child's health
Where this trial is running
St Louis, Missouri
- Washington University School of Medicine — St Louis, Missouri, United States (Recruiting)
Study contacts
- Principal investigator: Hadas Nahman-Averbuch, PhD — Washington University School of Medicine
- Study coordinator: Alana McMichael, MA
- Email: painlab@wustl.edu
- Phone: 314-273-6194
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.