Clinical trial Recruiting at 1 site Observational Ages 18 to 45 Women only

Effects of pelvic organ diseases on endometrial receptivity in infertile women

Official title: Fertility Limiting Diseases of Pelvic Organs and Their Influence on Receptivity of Endometrial Cavity: Prospective Clinical Trial (REAdME)

Run by Charles University, Czech Republic · NCT06991595 · Data updated 2026-11-12

This study is trying to see how conditions like adenomyosis, fibroids, and endometriosis affect the ability of the uterus to support pregnancy in women who are having trouble getting pregnant.

More Endometriosis trials

Quick facts

Study typeObservational
Ages18 Years to 45 Years
SexWomen only
Enrollment236 (estimated)
SponsorCharles University, Czech Republic
Academic / other
Locations1 site (Prague)
StatusRecruiting
StartedApril 1, 2023
Main results expectedApril 1, 2026
Study endsDecember 31, 2026
Registry record updatedMay 28, 2025
Trial IDNCT06991595 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are women aged 18-45 with at least one year of infertility and diagnosed with adenomyosis, fibroid uterus, or endometriosis.

Probably not a fit

Patients with infertility not related to adenomyosis, fibroid uterus, or endometriosis may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to characterize how fertility-limiting diseases such as adenomyosis, fibroid uterus, and endometriosis affect the receptivity of the endometrium in women experiencing infertility. The study will involve both laboratory and clinical components, including RNA sequencing to analyze gene expression differences in endometrial tissue. Patients with these conditions will be compared to those with minimal endometriosis and healthy controls to better understand the impact on fertility. The findings could lead to improved diagnostic tools and treatment options for affected women.

Why it matters

Potential benefit: If successful, this study could enhance fertility treatment strategies for women suffering from adenomyosis, fibroid uterus, and endometriosis.

How similar studies have gone: While this approach is innovative, similar studies have shown promise in understanding the relationship between endometrial receptivity and fertility-limiting conditions.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* agreement with participation in the study
* age between 18 - 45 years (at the start of patient´s participation in the study)women with at least 1 year infertility

Exclusion Criteria:

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Where it's running

  • General Hospital in Prague
    Prague, Czechia
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.