Effects of pelvic organ diseases on endometrial receptivity in infertile women
Fertility Limiting Diseases of Pelvic Organs and Their Influence on Receptivity of Endometrial Cavity: Prospective Clinical Trial (REAdME)
This study is trying to see how conditions like adenomyosis, fibroids, and endometriosis affect the ability of the uterus to support pregnancy in women who are having trouble getting pregnant.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 236 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | Female |
| Sponsor | Charles University, Czech Republic Academic / other |
| Locations | 1 site (Prague) |
| Trial ID | NCT06991595 on ClinicalTrials.gov |
What this trial studies
This project aims to characterize how fertility-limiting diseases such as adenomyosis, fibroid uterus, and endometriosis affect the receptivity of the endometrium in women experiencing infertility. The study will involve both laboratory and clinical components, including RNA sequencing to analyze gene expression differences in endometrial tissue. Patients with these conditions will be compared to those with minimal endometriosis and healthy controls to better understand the impact on fertility. The findings could lead to improved diagnostic tools and treatment options for affected women.
Who should consider this trial
Good fit: Ideal candidates are women aged 18-45 with at least one year of infertility and diagnosed with adenomyosis, fibroid uterus, or endometriosis.
Not a fit: Patients with infertility not related to adenomyosis, fibroid uterus, or endometriosis may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance fertility treatment strategies for women suffering from adenomyosis, fibroid uterus, and endometriosis.
How similar studies have performed: While this approach is innovative, similar studies have shown promise in understanding the relationship between endometrial receptivity and fertility-limiting conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * agreement with participation in the study * age between 18 - 45 years (at the start of patient´s participation in the study)women with at least 1 year infertility Exclusion Criteria: \-
Where this trial is running
Prague
- General Hospital in Prague — Prague, Czechia (Recruiting)
Study contacts
- Principal investigator: Michal Mara — General Hospital in Prague
- Study coordinator: Kristyna Hlinecka, MD, PhD
- Email: Kristyna.Hlinecka2@vfn.cz
- Phone: 00420605413210
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.