Effects of pelvic organ diseases on endometrial receptivity in infertile women
Official title: Fertility Limiting Diseases of Pelvic Organs and Their Influence on Receptivity of Endometrial Cavity: Prospective Clinical Trial (REAdME)
Run by Charles University, Czech Republic · NCT06991595 · Data updated 2026-11-12
This study is trying to see how conditions like adenomyosis, fibroids, and endometriosis affect the ability of the uterus to support pregnancy in women who are having trouble getting pregnant.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 236 (estimated) |
| Sponsor | Charles University, Czech Republic Academic / other |
| Locations | 1 site (Prague) |
| Status | Recruiting |
| Started | April 1, 2023 |
| Main results expected | April 1, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | May 28, 2025 |
| Trial ID | NCT06991595 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women aged 18-45 with at least one year of infertility and diagnosed with adenomyosis, fibroid uterus, or endometriosis.
✕Probably not a fit
Patients with infertility not related to adenomyosis, fibroid uterus, or endometriosis may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project aims to characterize how fertility-limiting diseases such as adenomyosis, fibroid uterus, and endometriosis affect the receptivity of the endometrium in women experiencing infertility. The study will involve both laboratory and clinical components, including RNA sequencing to analyze gene expression differences in endometrial tissue. Patients with these conditions will be compared to those with minimal endometriosis and healthy controls to better understand the impact on fertility. The findings could lead to improved diagnostic tools and treatment options for affected women.
Why it matters
Potential benefit: If successful, this study could enhance fertility treatment strategies for women suffering from adenomyosis, fibroid uterus, and endometriosis.
How similar studies have gone: While this approach is innovative, similar studies have shown promise in understanding the relationship between endometrial receptivity and fertility-limiting conditions.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * agreement with participation in the study * age between 18 - 45 years (at the start of patient´s participation in the study)women with at least 1 year infertility Exclusion Criteria: \-
Where it's running
-
General Hospital in Prague
Prague, Czechia Recruiting
Study contacts
- Principal investigator: Michal Mara — General Hospital in Prague
- Study coordinator: Kristyna Hlinecka, MD, PhD
- Email: Kristyna.Hlinecka2@vfn.cz
- Phone: 00420605413210
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Cannabinoid-based product for gynecologic pain in endometriosis, adenomyosis, or PID
This study tests a high-CBD, hemp-derived product against placebo in adults with gynecologic pain from endometriosis, adenomyosis, or PID over one week to see if it reduces pain and related symptoms.
-
Good pain consultation for endometriosis
This trial will test whether adding a 'good pain consultation' with early biopsychosocial pain education to usual care helps biological women with endometriosis manage pain and improve quality of life.
-
Measuring L-PGDS levels in blood, urine, vaginal fluid and endometrial tissue
This project will test whether L-PGDS levels in blood, urine, vaginal fluid and uterine tissue differ between women with adenomyosis, other benign uterine conditions, and healthy controls.
-
Improving diagnosis of endometriosis and adenomyosis using advanced analysis techniques
This study is trying to find better ways to diagnose endometriosis and adenomyosis in women by using advanced techniques that look at genetics and imaging to help personalize treatments.
-
Comparing different techniques to treat endometriosis
This study is testing different methods to treat endometriosis, like laser and heat techniques, to see which one works best for relieving pain in women who are already having surgery for the condition.
-
Investigating the effects of diet and therapy on endometriosis pain
This study is testing whether an anti-inflammatory diet and therapy can help women with endometriosis feel less pain and improve their quality of life.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.