Investigating the link between endometriosis and microbiota
A Study on the Correlation Between Endometriosis and Intra-tissue Microbiota
This study is trying to see if the bacteria in the bodies of women with endometriosis play a role in their condition by collecting and analyzing different samples from them.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 18 Years to 52 Years |
| Sex | Female |
| Sponsor | Zhujiang Hospital Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Trial ID | NCT06266897 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the correlation between endometriosis and intra-tissue microbiota by collecting various biological samples from participants. Women aged 18-52 with confirmed endometriosis will be recruited, and samples such as serum, vaginal swabs, cervical mucus, feces, and endometrial tissue will be analyzed through sequencing and laboratory experiments. The goal is to better understand the role of microbiota in the pathogenesis of endometriosis, which remains unclear.
Who should consider this trial
Good fit: Ideal candidates for this study are women aged 18-52 with a confirmed diagnosis of endometriosis.
Not a fit: Patients who are pregnant or have a history of malignant diseases will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new insights into the causes of endometriosis and potential new treatment strategies.
How similar studies have performed: While the investigation of microbiota in relation to endometriosis is a relatively novel approach, similar studies have shown promising results in other tumor types.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Women aged 18-52 years old. 2. Regular menstruation with a cycle of 28-35 days. 3. No sexual intercourse 1 week before the operation. 4. No systemic or local use of antibiotics and probiotics for 6 months prior to surgery. 5. No history of acute or chronic pelvic inflammatory disease. 6. Subjects fully understand the significance of the study and sign the informed consent form. Exclusion Criteria: 1. In pregnancy. 2. Intraoperative conditions or pathological examination suggest a malignant or junctional disease. 3. Severe anatomical abnormalities of the pelvis. 4. Pelvic contamination with large amounts of blood during laparoscopic operation. 5. History of gene therapy, blood transfusion, stem cell therapy, or bone marrow transplantation 6. Psychiatric, personality disorders, or abuse of psychoactive substances. 7. Immunodeficiencies, allergies, or autoimmune diseases. 8. Contraindications to endotracheal intubation anesthesia. 9. Absolute or relative contraindications to laparoscopic or hysteroscopic surgery.
Where this trial is running
Guangzhou, Guangdong
- Zhujiang Hospital — Guangzhou, Guangdong, China (Recruiting)
Study contacts
- Principal investigator: Ying Ma, PhD — Zhujiang Hospital, Southern Medical University, China
- Study coordinator: Ziwei Zhou, Dr
- Email: vivienchow@qq.com
- Phone: +8615626400134
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.