Investigating the link between endometriosis and microbiota
Official title: A Study on the Correlation Between Endometriosis and Intra-tissue Microbiota
Run by Zhujiang Hospital · NCT06266897 · Data updated 2026-11-12
This study is trying to see if the bacteria in the bodies of women with endometriosis play a role in their condition by collecting and analyzing different samples from them.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 52 Years |
| Sex | Women only |
| Enrollment | 500 (estimated) |
| Sponsor | Zhujiang Hospital Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Status | Recruiting |
| Started | June 18, 2023 |
| Main results expected | December 2026 |
| Study ends | December 2026 |
| Registry record updated | February 20, 2024 |
| Trial ID | NCT06266897 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are women aged 18-52 with a confirmed diagnosis of endometriosis.
✕Probably not a fit
Patients who are pregnant or have a history of malignant diseases will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the correlation between endometriosis and intra-tissue microbiota by collecting various biological samples from participants. Women aged 18-52 with confirmed endometriosis will be recruited, and samples such as serum, vaginal swabs, cervical mucus, feces, and endometrial tissue will be analyzed through sequencing and laboratory experiments. The goal is to better understand the role of microbiota in the pathogenesis of endometriosis, which remains unclear.
Why it matters
Potential benefit: If successful, this study could lead to new insights into the causes of endometriosis and potential new treatment strategies.
How similar studies have gone: While the investigation of microbiota in relation to endometriosis is a relatively novel approach, similar studies have shown promising results in other tumor types.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Women aged 18-52 years old. 2. Regular menstruation with a cycle of 28-35 days. 3. No sexual intercourse 1 week before the operation. 4. No systemic or local use of antibiotics and probiotics for 6 months prior to surgery. 5. No history of acute or chronic pelvic inflammatory disease. 6. Subjects fully understand the significance of the study and sign the informed consent form. Exclusion Criteria: 1. In pregnancy. 2. Intraoperative conditions or pathological examination suggest a malignant or junctional disease. 3. Severe anatomical abnormalities of the pelvis. 4. Pelvic contamination with large amounts of blood during laparoscopic operation. 5. History of gene therapy, blood transfusion, stem cell therapy, or bone marrow transplantation 6. Psychiatric, personality disorders, or abuse of psychoactive substances. 7. Immunodeficiencies, allergies, or autoimmune diseases. 8. Contraindications to endotracheal intubation anesthesia. 9. Absolute or relative contraindications to laparoscopic or hysteroscopic surgery.
Where it's running
-
Zhujiang Hospital
Guangzhou, Guangdong, China Recruiting
Study contacts
- Principal investigator: Ying Ma, PhD — Zhujiang Hospital, Southern Medical University, China
- Study coordinator: Ziwei Zhou, Dr
- Email: vivienchow@qq.com
- Phone: +8615626400134
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Imaging endometriosis with a special PET tracer in adult women
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Stellate ganglion block and dexmedetomidine for better sleep after gynecologic laparoscopy
The study tests whether giving a preoperative stellate ganglion block plus intraoperative dexmedetomidine improves sleep after laparoscopic gynecologic surgery in women.
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Atypical Endometriosis: Histology, Immunophenotype and Molecular Features
Researchers will look at how endometriotic tissue that looks atypical under the microscope relates to clinical features and ultrasound findings to better separate benign from potentially atypical lesions.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.