Understanding the progression of endometriosis and adenomyosis
ENDOCHAP Monocentric Cohort: Clinical and Molecular Study of Endometriosis and Adenomyosis
This study is trying to see if endometriosis and adenomyosis get worse over time by looking at symptoms and other factors to help improve diagnosis and treatment for those affected.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 5300 (estimated) |
| Ages | 18 Years to 42 Years |
| Sex | Female |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris) |
| Trial ID | NCT04481321 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate whether endometriosis and adenomyosis are progressive diseases by examining symptoms such as pain, abnormal uterine bleeding, and infertility, as well as the size of anatomical lesions and recurrence rates. The study will also explore molecular aspects, including immune interactions between ectopic lesions and the normal endometrium, autoimmune responses, and the role of microbiota in these conditions. By identifying specific clinical and molecular markers, the research seeks to reduce the time taken for accurate diagnosis and management of these conditions.
Who should consider this trial
Good fit: Ideal candidates for this study are women aged 18 to 42 who are experiencing pelvic pain, infertility, or have a pelvic mass, and have a radiological diagnosis.
Not a fit: Patients who are HIV-positive, pregnant, have a cancer diagnosis, or refuse to sign consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic methods and management strategies for women suffering from endometriosis and adenomyosis.
How similar studies have performed: Other studies have explored aspects of endometriosis and adenomyosis, but this specific approach focusing on disease progression and molecular markers is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women of age between - 18 and 42 years old. * In-service care for one of the pelvic pain and/or infertility, or for a pelvic mass. * Having a radiological diagnosis made by a referral practitioner and/or operated in the department Exclusion Criteria: * HIV-positive women, HBV and HCV * During pregnancy * Having a cancer diagnosis * Refusing to sign a consent.
Where this trial is running
Paris
- Port Royal, hospital cochin — Paris, France (Recruiting)
Study contacts
- Principal investigator: Louis Marcellin, MD, PhD — Assistance Publique - Hôpitaux de Paris
- Study coordinator: Charles Chapron, MD
- Email: charles.chapron@aphp.fr
- Phone: 1 58 41 19 33
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.