Understanding the progression of endometriosis and adenomyosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate whether endometriosis and adenomyosis are progressive diseases by examining symptoms such as pain, abnormal uterine bleeding, and infertility, as well as the size of anatomical lesions and recurrence rates. The study will also explore molecular aspects, including immune interactions between ectopic lesions and the normal endometrium, autoimmune responses, and the role of microbiota in these conditions. By identifying specific clinical and molecular markers, the research seeks to reduce the time taken for accurate diagnosis and management of these conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women of age between - 18 and 42 years old.
* In-service care for one of the pelvic pain and/or infertility, or for a pelvic mass.
* Having a radiological diagnosis made by a referral practitioner and/or operated in the department

Exclusion Criteria:

* HIV-positive women, HBV and HCV
* During pregnancy
* Having a cancer diagnosis
* Refusing to sign a consent.

Where it's running

• Port Royal, hospital cochin
  Paris, France Recruiting

Study contacts

• Principal investigator: Louis Marcellin, MD, PhD — Assistance Publique - Hôpitaux de Paris
• Study coordinator: Charles Chapron, MD
• Email: charles.chapron@aphp.fr
• Phone: 1 58 41 19 33

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Cannabinoid-based product for gynecologic pain in endometriosis, adenomyosis, or PID

  This study tests a high-CBD, hemp-derived product against placebo in adults with gynecologic pain from endometriosis, adenomyosis, or PID over one week to see if it reduces pain and related symptoms.

  Recruiting Phase 1/2 Mclean Hospital · Belmont, Massachusetts · NCT07728695

• Good pain consultation for endometriosis

  This trial will test whether adding a 'good pain consultation' with early biopsychosocial pain education to usual care helps biological women with endometriosis manage pain and improve quality of life.

  Recruiting Sorlandet Hospital HF · Kristiansand, Agder · NCT07205614

• Effects of pelvic organ diseases on endometrial receptivity in infertile women

  This study is trying to see how conditions like adenomyosis, fibroids, and endometriosis affect the ability of the uterus to support pregnancy in women who are having trouble getting pregnant.

  Recruiting Charles University, Czech Republic · Prague · NCT06991595

• Measuring L-PGDS levels in blood, urine, vaginal fluid and endometrial tissue

  This project will test whether L-PGDS levels in blood, urine, vaginal fluid and uterine tissue differ between women with adenomyosis, other benign uterine conditions, and healthy controls.

  Recruiting Centre Hospitalier Universitaire de Nīmes · Nîmes · NCT06864494

• Improving diagnosis of endometriosis and adenomyosis using advanced analysis techniques

  This study is trying to find better ways to diagnose endometriosis and adenomyosis in women by using advanced techniques that look at genetics and imaging to help personalize treatments.

  Recruiting IRCCS San Raffaele · Catanzaro, Catanzaro and 1 other locations · NCT06572852

• Comparing different techniques to treat endometriosis

  This study is testing different methods to treat endometriosis, like laser and heat techniques, to see which one works best for relieving pain in women who are already having surgery for the condition.

  Recruiting TriHealth Inc. · Cincinnati, Ohio · NCT06414083

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.