Hormonal Influences on Inflammation in Endometriosis
Funded at University of Texas Hlth Science Center · NIH-11588229 · Data updated 2026-11-12
A study in adult women with endometriosis looks at how hormones and immune pathways interact to influence inflammation and symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | September 25, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $171,386 |
| NIH project number | 3R01HG013258-03S1 |
| Project ID | NIH-11588229 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adult women with endometriosis or those at risk due to inflammatory profiles may be eligible for future studies or related trials.
✕Less likely to help
The study itself does not involve direct treatment for participants; it analyzes existing data and biological samples.
What this research studies
This project focuses on how hormonal signals interact with immune pathways to affect endometriosis, using large genetic datasets and advanced single-cell analyses. Researchers will map shared risk genes between endometriosis and inflammatory conditions and explore how these genes behave in hormone-rich environments. The goal is to identify key biological pathways that could explain why endometriosis triggers pain and related symptoms. The work combines population genetics with cutting-edge cellular analyses to pinpoint targets for future therapies.
Why it matters
Potential benefit: If successful, findings could lead to new hormone- and immune-based approaches to treat endometriosis symptoms.
How similar studies have gone: Prior research has linked inflammatory pathways and hormonal responses to endometriosis, supporting a translational path for this approach.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Lawrenson, Kate — University of Texas Hlth Science Center
- Study coordinator: Lawrenson, Kate
Related research
Other NIH-funded projects on the same topics.
-
Molecular clues to endometriosis-related infertility
This grant explores how molecular changes in endometriosis contribute to infertility, with the aim of finding better ways to diagnose and treat the condition.
-
How genes influence endometriosis in women of different racial and ethnic backgrounds
The team will compare genetic changes in tissue from women of various races who have endometriosis to find molecular targets for better treatments.
-
Quantum diamond sensor endoscopy to map iron in endometriosis
A tiny quantum sensor built into an endoscope will map iron in endometriosis lesions to help diagnose the disease noninvasively.
-
Understanding how RPLP1 affects endometriosis and adenomyosis
A patient-focused look at how a ribosomal protein called RPLP1 may drive tissue changes in endometriosis and adenomyosis and what this could mean for future therapies.
-
CXCR4 methylation in endometriosis and its role as an early biomarker and non-hormonal therapy target
This project explores how changes in CXCR4 gene regulation may help diagnose endometriosis earlier and point toward non-hormonal treatments for the condition.
-
Hormonal links to inflammation in endometriosis
A study to understand how hormones influence immune signals in endometriosis to help explain symptoms and identify potential targets for treatment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.