Developing a new non-hormonal treatment for endometriosis
Official title: Novel, Non-hormonal Therapeutic for Endometriosis
Funded at Endomet Biosciences, INC · NIH-11300271 · Data updated 2026-11-12
This study is working on a new treatment for endometriosis that doesn't use hormones and aims to actually change the disease instead of just easing the symptoms, and women with this condition may have a chance to join clinical trials as the research moves forward.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Endomet Biosciences, INC NIH-funded |
| Lab location | 1 site (Irvine, UNITED STATES) |
| Project start | September 1, 2019 |
| Project end | August 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $177,500 |
| NIH project number | 3R44HD100289-06S1 |
| Project ID | NIH-11300271 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women diagnosed with endometriosis, particularly those who have not found relief from existing hormonal treatments.
✕Less likely to help
Patients who have not been diagnosed with endometriosis or those who have already undergone a hysterectomy may not benefit from this research.
What this research studies
This research aims to create the first disease-modifying and non-hormonal therapy for endometriosis, a condition affecting about 10% of women globally. The project addresses the limitations of current treatments, which often involve hormonal therapies that can have undesirable side effects and do not cure the disease. By focusing on a novel therapeutic approach, the research seeks to target the underlying causes of endometriosis rather than just managing symptoms. Patients may have the opportunity to participate in clinical trials as the research progresses.
Why it matters
Potential benefit: If successful, this research could provide a much-needed cure for endometriosis, significantly improving the quality of life for affected women.
How similar studies have gone: While there have been various approaches to treating endometriosis, this specific non-hormonal therapeutic strategy is novel and has not been extensively tested in clinical settings.
Where this research is happening
-
Endomet Biosciences, INC
Irvine, United States Active
Researchers
- Principal investigator: Petrossian, Tanya Christineh — Endomet Biosciences, INC
- Study coordinator: Petrossian, Tanya Christineh
Related research
Other NIH-funded projects on the same topics.
-
Molecular clues to endometriosis-related infertility
This grant explores how molecular changes in endometriosis contribute to infertility, with the aim of finding better ways to diagnose and treat the condition.
-
Hormonal Influences on Inflammation in Endometriosis
A study in adult women with endometriosis looks at how hormones and immune pathways interact to influence inflammation and symptoms.
-
How genes influence endometriosis in women of different racial and ethnic backgrounds
The team will compare genetic changes in tissue from women of various races who have endometriosis to find molecular targets for better treatments.
-
Quantum diamond sensor endoscopy to map iron in endometriosis
A tiny quantum sensor built into an endoscope will map iron in endometriosis lesions to help diagnose the disease noninvasively.
-
Understanding how RPLP1 affects endometriosis and adenomyosis
A patient-focused look at how a ribosomal protein called RPLP1 may drive tissue changes in endometriosis and adenomyosis and what this could mean for future therapies.
-
CXCR4 methylation in endometriosis and its role as an early biomarker and non-hormonal therapy target
This project explores how changes in CXCR4 gene regulation may help diagnose endometriosis earlier and point toward non-hormonal treatments for the condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.