Argon plasma coagulation versus standard cystectomy for ovarian endometrioma
Official title: Argon Plasma Treatment for Ovarian Endometrioma Compared to Standard Cystectomy: A Prospective Controlled Randomized Pilot Study
Run by Erbe Elektromedizin GmbH · NCT07065214 · Data updated 2026-11-12
This trial will test whether argon plasma coagulation preserves ovarian reserve better than standard cystectomy for people having surgery for ovarian endometriomas.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 40 Years |
| Sex | Women only |
| Enrollment | 72 (estimated) |
| Sponsor | Erbe Elektromedizin GmbH Industry-sponsored |
| Locations | 1 site (Tübingen, Germany) |
| Status | Recruiting |
| Started | November 26, 2025 |
| Main results expected | November 1, 2028 |
| Study ends | May 30, 2029 |
| Registry record updated | October 7, 2026 |
| Trial ID | NCT07065214 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
People with symptomatic ovarian endometriomas who are scheduled for surgical treatment, can give informed consent, and meet the study's eligibility criteria are ideal candidates.
✕Probably not a fit
Patients who have had prior ovarian surgery, recurrent ovarian endometrioma, are pregnant or breastfeeding, cannot comply with follow-up, or are enrolled in other studies affecting AMH are not eligible and likely would not benefit from this trial.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, single-center, randomized controlled pilot trial enrolling 72 patients with symptomatic ovarian endometriomas who are scheduled for surgery. Participants are randomized 1:1 to receive either standard cystectomy or argon plasma coagulation (APC) during laparoscopy. The main outcome compares changes in serum AMH from before surgery to follow-up at 6 months, with a pre-specified primary endpoint analysis after the last patient completes Visit 4. The trial is conducted at the Department for Women's Health in Tübingen, Germany, under a post-market evaluation framework.
Why it matters
Potential benefit: If successful, APC could better preserve ovarian reserve and reduce the impact of surgery on future fertility compared with standard cystectomy.
How similar studies have gone: Standard cystectomy is a well-established treatment known to affect ovarian reserve, while APC for ovarian endometrioma is less studied and has only limited preliminary evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Indication for surgical endometrioma treatment according to patient symptoms * Signed informed consent Exclusion Criteria: * Expected lack of patient compliance or inability of the patient to understand the purpose of the clinical trial * Prior procedures at the ovaries * Recurrent endometrioma (patients with recurrent endometriosis outside of the ovar, e.g. peritoneal endometriosis lesions can be included) * Pregnant or breastfeeding patients * Participation in any other clinical study that could affect the AMH level or pregnancy
Where it's running
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Department for Women's Health
Tübingen, Germany, Germany Recruiting
Study contacts
- Principal investigator: Bernhard Krämer, Prof. Dr. med. — Department for Women's Health, Tuebingen, Germany
- Study coordinator: Vanessa Steinmetz
- Email: vanessa.steinmetz@erbe-med.com
- Phone: +49 70717552850
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.