Using magnetic stimulation to reduce pain from endometriosis
Is Repetitive Transcranial Magnetic Stimulation Effective in Reducing Endometriosis-associated Pain: A Randomized Controlled Trial
This study is testing whether a type of magnetic stimulation can help people with endometriosis pain who haven't found relief from other treatments.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 152 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | Female |
| Sponsor | University of Ottawa Academic / other |
| Locations | 1 site (Ottawa, Ontario) |
| Trial ID | NCT06333353 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in reducing endometriosis-associated pain (EAP) in individuals who have not found relief from previous treatments. It employs a double-blind, randomized-controlled design with four groups receiving either real or sham rTMS for either 5 or 10 sessions. The study will assess pain outcomes and the potential benefits of different treatment durations. The protocol adheres to established reporting standards and focuses on patient-oriented research.
Who should consider this trial
Good fit: Ideal candidates are individuals with self-reported endometriosis-associated pain that persists despite medical or surgical interventions.
Not a fit: Patients with contraindications to rTMS, such as those with metal implants or a history of seizures, will not benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could provide a new, effective treatment option for individuals suffering from chronic pain due to endometriosis.
How similar studies have performed: Previous feasibility trials have shown promising results for rTMS in reducing endometriosis-associated pain, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: -self-reported endometriosis-associated pain (\> 3 in the numeric rating scale, 0-10) that has persisted following medical or surgical intervention, Exclusion Criteria: * Contra-indications to rTMS (e.g., metal/implants around the head/neck, pacemaker), history of epilepsy (history of seizures) in the family * Pain symptoms initiated by other known causes (e.g., infections, thyroid disease, autoimmune diseases, gastrointestinal disease) * Experience a more severe, extra-pelvic pain than that associated with endometriosis * Pregnancy
Where this trial is running
Ottawa, Ontario
- McLean Function Measurement Lab — Ottawa, Ontario, Canada (Recruiting)
Study contacts
- Principal investigator: Linda McLean, PhD — University of Ottawa
- Study coordinator: Anne-Marie MacDonald, MSc
- Email: alake@uottawa.ca
- Phone: 613-562-5800
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.