EUmetriosis: new insights into how endometriosis develops
EUmetriosis: Insights Into the Pathogenesis of Endometriosis
NA · Université Catholique de Louvain · NCT07000786
This study will see if epigenetic changes in menstrual blood and plasma can be used to find a non-invasive test for women with endometriosis.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 56 Years |
| Sex | Female |
| Sponsor | Université Catholique de Louvain (other) |
| Locations | 1 site (Brussels) |
| Trial ID | NCT07000786 on ClinicalTrials.gov |
What this trial studies
This interventional study collects menstrual effluent (via menstrual cup or endometrial biopsy) and blood samples from premenopausal women in natural menstrual cycles, including those with a confirmed diagnosis of endometriosis and healthy controls. Researchers will analyze epigenetic marks in menstrual and plasma samples to look for patterns that distinguish women with endometriosis from those without. Participants must not have used hormonal treatments in the prior three months and are excluded if pregnant or HIV/hepatitis positive. The goal is to identify candidate non-invasive biomarkers that could reduce reliance on invasive diagnostic procedures.
Who should consider this trial
Good fit: Ideal candidates are premenopausal women in a spontaneous (non-hormonally treated) menstrual cycle, either healthy or with endometriosis confirmed by ultrasound, MRI, or laparoscopy.
Not a fit: Women who are pregnant, currently using hormonal treatments, or who are HIV- or hepatitis-positive will not qualify and thus will not benefit from participation.
Why it matters
Potential benefit: If successful, this could lead to a non-invasive menstrual or blood test that helps diagnose endometriosis earlier and reduce the need for surgery.
How similar studies have performed: Previous research has found epigenetic differences in endometrial tissue and some blood-based signals, but robust, clinically validated non-invasive biomarkers for endometriosis have not yet been established.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Premenopausal * In spontaneous menstrual cycle (no hormonal treatments for the last 3 months) * Healthy or with a clear diagnosis of endometriosis via ultrasound, MRI or laparoscopy Exclusion Criteria: * HIV or Hepatitis positive * Pregnancy
Where this trial is running
Brussels
- Cliniques universitaires Saint-Luc — Brussels, Belgium (RECRUITING)
Study contacts
- Study coordinator: Marie-Madeleine Dolmans, MD, PhD
- Email: marie-madeleine.dolmans@uclouvain.be
- Phone: +32 (0)2 764 5287
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Endometriosis