EUmetriosis: new insights into how endometriosis develops

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study collects menstrual effluent (via menstrual cup or endometrial biopsy) and blood samples from premenopausal women in natural menstrual cycles, including those with a confirmed diagnosis of endometriosis and healthy controls. Researchers will analyze epigenetic marks in menstrual and plasma samples to look for patterns that distinguish women with endometriosis from those without. Participants must not have used hormonal treatments in the prior three months and are excluded if pregnant or HIV/hepatitis positive. The goal is to identify candidate non-invasive biomarkers that could reduce reliance on invasive diagnostic procedures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Premenopausal
* In spontaneous menstrual cycle (no hormonal treatments for the last 3 months)
* Healthy or with a clear diagnosis of endometriosis via ultrasound, MRI or laparoscopy

Exclusion Criteria:

* HIV or Hepatitis positive
* Pregnancy

Where it's running

• Cliniques universitaires Saint-Luc
  Brussels, Belgium Recruiting

Study contacts

• Study coordinator: Marie-Madeleine Dolmans, MD, PhD
• Email: marie-madeleine.dolmans@uclouvain.be
• Phone: +32 (0)2 764 5287

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Comparing different techniques to treat endometriosis

  This study is testing different methods to treat endometriosis, like laser and heat techniques, to see which one works best for relieving pain in women who are already having surgery for the condition.

  Recruiting TriHealth Inc. · Cincinnati, Ohio · NCT06414083

• Postoperative Pain Trajectories After Endometriosis Surgery

  This study tests how pain changes after endometriosis surgery and whether perioperative pain testing can predict who will have ongoing pain.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07882498

• Imaging endometriosis with a special PET tracer in adult women

  This study tests whether a PET/CT scan using [18F]AlF-FAPI-74 can help detect endometriosis lesions in women who are planning laparoscopy.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT07876648

• Fiber supplement for digestive symptoms in endometriosis

  A fiber-based supplement is being tested to see if it is safe and helps with gut and vaginal microbiomes and digestive symptoms in women with endometriosis.

  Recruiting LOAM Science · San Francisco, California · NCT07875062

• Stellate ganglion block and dexmedetomidine for better sleep after gynecologic laparoscopy

  The study tests whether giving a preoperative stellate ganglion block plus intraoperative dexmedetomidine improves sleep after laparoscopic gynecologic surgery in women.

  Recruiting The Second People's Hospital of Huai'an · Huai'an, Jiangsu · NCT07860203

• Atypical Endometriosis: Histology, Immunophenotype and Molecular Features

  Researchers will look at how endometriotic tissue that looks atypical under the microscope relates to clinical features and ultrasound findings to better separate benign from potentially atypical lesions.

  Recruiting Casa di Cura Dott. Pederzoli · Peschiera del Garda, Verona · NCT07816133

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.