Probiotics for treating endometriosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of specific multistrain probiotics on patients with endometriosis. It is a randomized, double-blinded, placebo-controlled, cross-over trial that aims to determine if probiotic treatment can significantly alter gut microbiome composition and functionality in these patients. Participants will undergo a six-month study period, which includes two intervention phases with a washout period in between to allow the gut microbiome to return to baseline. The study will assess various outcome measures, including gut microbiome changes and quality of life, at four distinct time points.

Why it matters

Who can join: the full rules

Minimum Age: - Maximum Age: 35 Years Sex: Female Gender Based: Ye - only women can participate in this study Accepts Healthy Volunteers: No

Inclusion Criteria:

* adult subjects with stage III or IV endometriosis diagnosis confirmed by biopsy

Exclusion Criteria:

* Age \> 35 years
* Immunocompromised patients
* Patients with chronic inflammatory diseases (e.g., autoimmune disorders)
* Pregnancy
* Use of supplements and foods with probiotics
* Use of immunosuppressant, antibiotic, proton pump inhibitors and corticosteroid drugs
* Use of probiotics product less than one month before start of study or during study

Where it's running

• University Hospital Center Zagreb
  Zagreb, Croatia Recruiting

Study contacts

• Study coordinator: Ira Renko, MS
• Email: ira.renko@gmail.com
• Phone: 955096473

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Comparing different techniques to treat endometriosis

  This study is testing different methods to treat endometriosis, like laser and heat techniques, to see which one works best for relieving pain in women who are already having surgery for the condition.

  Recruiting TriHealth Inc. · Cincinnati, Ohio · NCT06414083

• Probiotics vs Antibiotics as an add-on to non-surgical periodontal care in adult smokers with stage II, grade B periodontitis

  This study tests whether systemic probiotics or systemic antibiotics added to standard non-surgical periodontal treatment help improve gum health in adult smokers with stage II, grade B periodontitis.

  Recruiting October 6 University · Cairo · NCT07923695

• Postoperative Pain Trajectories After Endometriosis Surgery

  This study tests how pain changes after endometriosis surgery and whether perioperative pain testing can predict who will have ongoing pain.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07882498

• Imaging endometriosis with a special PET tracer in adult women

  This study tests whether a PET/CT scan using [18F]AlF-FAPI-74 can help detect endometriosis lesions in women who are planning laparoscopy.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT07876648

• Fiber supplement for digestive symptoms in endometriosis

  A fiber-based supplement is being tested to see if it is safe and helps with gut and vaginal microbiomes and digestive symptoms in women with endometriosis.

  Recruiting LOAM Science · San Francisco, California · NCT07875062

• Stellate ganglion block and dexmedetomidine for better sleep after gynecologic laparoscopy

  The study tests whether giving a preoperative stellate ganglion block plus intraoperative dexmedetomidine improves sleep after laparoscopic gynecologic surgery in women.

  Recruiting The Second People's Hospital of Huai'an · Huai'an, Jiangsu · NCT07860203

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.