Developing a new non-hormonal treatment for endometriosis

Novel, Non-hormonal Therapeutic for Endometriosis

NIH-funded research Endomet Biosciences, INC · NIH-11186444

This study is testing a new treatment called ENDO-205 for endometriosis, which aims to help women by targeting the disease directly without the side effects of current options, making it a promising step towards better health for those affected.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionEndomet Biosciences, INC NIH-funded
Lab location1 site (Irvine, UNITED STATES)
Project IDNIH-11186444 on NIH RePORTER

What this research studies

This research aims to create the first disease-modifying and non-hormonal therapy for endometriosis, a condition affecting about 10% of women globally. The project focuses on developing a novel therapeutic called ENDO-205, which targets specific pathways involved in the disease's progression. Unlike current treatments that often have undesirable side effects and do not address the root cause, ENDO-205 is designed to be absorbed only by endometriosis tissue, potentially offering a more effective solution. The research is part of a broader initiative to improve women's health and is recognized as a high priority by the NICHD.

Who could benefit from this research

Good fit: Ideal candidates for this research are women diagnosed with endometriosis who are seeking alternative treatment options beyond hormonal therapies.

Not a fit: Patients who do not have endometriosis or those who have already undergone definitive surgical treatment may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could provide a much-needed curative option for women suffering from endometriosis, significantly improving their quality of life.

How similar studies have performed: While there have been various approaches to treating endometriosis, the specific non-hormonal therapeutic strategy being developed in this research is novel and has not been extensively tested in prior studies.

Where this research is happening

Irvine, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.