Developing a new non-hormonal treatment for endometriosis
Official title: Novel, Non-hormonal Therapeutic for Endometriosis
Funded at Endomet Biosciences, INC · NIH-11186444 · Data updated 2026-11-12
This study is testing a new treatment called ENDO-205 for endometriosis, which aims to help women by targeting the disease directly without the side effects of current options, making it a promising step towards better health for those affected.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Endomet Biosciences, INC NIH-funded |
| Lab location | 1 site (Irvine, UNITED STATES) |
| Project start | April 10, 2025 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $2,045,782 |
| NIH project number | 1SB1HD118921-01 |
| Project ID | NIH-11186444 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women diagnosed with endometriosis who are seeking alternative treatment options beyond hormonal therapies.
✕Less likely to help
Patients who do not have endometriosis or those who have already undergone definitive surgical treatment may not benefit from this research.
What this research studies
This research aims to create the first disease-modifying and non-hormonal therapy for endometriosis, a condition affecting about 10% of women globally. The project focuses on developing a novel therapeutic called ENDO-205, which targets specific pathways involved in the disease's progression. Unlike current treatments that often have undesirable side effects and do not address the root cause, ENDO-205 is designed to be absorbed only by endometriosis tissue, potentially offering a more effective solution. The research is part of a broader initiative to improve women's health and is recognized as a high priority by the NICHD.
Why it matters
Potential benefit: If successful, this research could provide a much-needed curative option for women suffering from endometriosis, significantly improving their quality of life.
How similar studies have gone: While there have been various approaches to treating endometriosis, the specific non-hormonal therapeutic strategy being developed in this research is novel and has not been extensively tested in prior studies.
Where this research is happening
-
Endomet Biosciences, INC
Irvine, United States Active
Researchers
- Principal investigator: Petrossian, Tanya Christineh — Endomet Biosciences, INC
- Study coordinator: Petrossian, Tanya Christineh
Related research
Other NIH-funded projects on the same topics.
-
Molecular clues to endometriosis-related infertility
This grant explores how molecular changes in endometriosis contribute to infertility, with the aim of finding better ways to diagnose and treat the condition.
-
Hormonal Influences on Inflammation in Endometriosis
A study in adult women with endometriosis looks at how hormones and immune pathways interact to influence inflammation and symptoms.
-
How genes influence endometriosis in women of different racial and ethnic backgrounds
The team will compare genetic changes in tissue from women of various races who have endometriosis to find molecular targets for better treatments.
-
Quantum diamond sensor endoscopy to map iron in endometriosis
A tiny quantum sensor built into an endoscope will map iron in endometriosis lesions to help diagnose the disease noninvasively.
-
Understanding how RPLP1 affects endometriosis and adenomyosis
A patient-focused look at how a ribosomal protein called RPLP1 may drive tissue changes in endometriosis and adenomyosis and what this could mean for future therapies.
-
CXCR4 methylation in endometriosis and its role as an early biomarker and non-hormonal therapy target
This project explores how changes in CXCR4 gene regulation may help diagnose endometriosis earlier and point toward non-hormonal treatments for the condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.