Using low-dose ketamine during surgery to treat endometriosis pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of intraoperative administration of low-dose ketamine during laparoscopic surgery for endometriosis on postoperative pain outcomes. It aims to compare pain levels experienced by patients who receive ketamine versus those who do not, focusing on the management of chronic pelvic pain associated with endometriosis. The study includes patients aged 18 and older who are undergoing surgery for endometriosis at the Inselspital, Bern University Hospital. The trial will assess the effectiveness of ketamine in reducing the need for opioids and improving recovery after surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients undergoing surgery for endometriosis operation requiring general anaesthesia at the Inselspital, Bern University Hospital, University of Bern, Department of gynaecology and obstetrics.
* Age ≥ 18 years
* American Society of Anesthesiologist (ASA) physical status 1-3
* Patients with known or suspected endometriosis
* Written informed consent.

Exclusion Criteria:

* Age \< 18 years
* ASA physical status ≥4
* Higher-grade atrioventricular block without pacemaker
* Severe hypovolemia or bradycardia
* Uncontrolled hyper- or hypotension
* Liver disease
* Known malignant hyperthermia
* Cardiovascular instability or severe heart failure (New York Heart Association classification (NYHA) \> III)
* Myocardial infarction during the last 30 days prior to surgery
* Increased intracranial or increased intraocular pressure
* Limited peripheral autonomic activity, hypersensitivity to ketamine or propofol or its components
* Pregnancy
* Rejection or lack of consent of the patient or relatives

Where it's running

• Inselspital Bern
  Bern, Switzerland Recruiting

Study contacts

• Study coordinator: Christian Vetter, MD
• Email: christian.vetter@insel.ch
• Phone: +416343776

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Comparing different techniques to treat endometriosis

  This study is testing different methods to treat endometriosis, like laser and heat techniques, to see which one works best for relieving pain in women who are already having surgery for the condition.

  Recruiting TriHealth Inc. · Cincinnati, Ohio · NCT06414083

• Postoperative Pain Trajectories After Endometriosis Surgery

  This study tests how pain changes after endometriosis surgery and whether perioperative pain testing can predict who will have ongoing pain.

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• Imaging endometriosis with a special PET tracer in adult women

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  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT07876648

• Fiber supplement for digestive symptoms in endometriosis

  A fiber-based supplement is being tested to see if it is safe and helps with gut and vaginal microbiomes and digestive symptoms in women with endometriosis.

  Recruiting LOAM Science · San Francisco, California · NCT07875062

• Stellate ganglion block and dexmedetomidine for better sleep after gynecologic laparoscopy

  The study tests whether giving a preoperative stellate ganglion block plus intraoperative dexmedetomidine improves sleep after laparoscopic gynecologic surgery in women.

  Recruiting The Second People's Hospital of Huai'an · Huai'an, Jiangsu · NCT07860203

• Atypical Endometriosis: Histology, Immunophenotype and Molecular Features

  Researchers will look at how endometriotic tissue that looks atypical under the microscope relates to clinical features and ultrasound findings to better separate benign from potentially atypical lesions.

  Recruiting Casa di Cura Dott. Pederzoli · Peschiera del Garda, Verona · NCT07816133

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.