Selective removal of endometriotic lining from ovarian endometriomas using CUSA Clarity
Official title: Selective Removal of Endometriotic Lesions Using CUSA Clarity in Ovarian Endometriomas: A Case-Based Histopathological Study
Run by Kanazawa University · NCT07215130 · Data updated 2026-11-12
This project will try the CUSA Clarity device on tissue from women with ovarian endometriomas to see if it removes endometriotic lining while preserving healthy ovarian tissue.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 20 Years and up |
| Sex | Women only |
| Enrollment | 10 (estimated) |
| Sponsor | Kanazawa University Academic / other |
| Locations | 1 site (Kanazawa, Ishikawa-ken) |
| Status | Recruiting |
| Started | January 30, 2025 |
| Main results expected | March 31, 2027 |
| Study ends | March 31, 2028 |
| Registry record updated | October 10, 2025 |
| Trial ID | NCT07215130 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women aged 20 or older undergoing surgical treatment for ovarian endometrioma at Kanazawa University Hospital who provide written informed consent between January 1, 2025 and March 31, 2027 are eligible.
✕Probably not a fit
Patients with suspected malignancy on preoperative imaging, those not undergoing surgical removal of an endometrioma, or those who do not consent are unlikely to receive benefit from this ex vivo tissue study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In this observational ex vivo histopathology study, ovarian endometrioma wall specimens obtained during surgery are divided and treated with the CUSA Clarity ultrasonic aspirator using Tissue Select settings 0–4. Treated samples are fixed, paraffin-embedded, and stained with hematoxylin-eosin plus immunohistochemical markers (for example, cytokeratin 7 and CD10). Pathologists evaluate the extent of removal of endometriotic epithelium, preservation of ovarian stroma, depth of tissue removal, and presence of residual lesions at margins. The findings are intended to inform whether CUSA Clarity could be adapted for fertility-preserving surgical approaches to ovarian endometriomas.
Why it matters
Potential benefit: If successful, this approach could allow removal of endometriotic tissue while preserving ovarian reserve and improving fertility prospects.
How similar studies have gone: Ultrasonic aspirators like CUSA have demonstrated tissue-selective effects in other surgical settings, but applying CUSA Clarity specifically to selectively remove endometriotic epithelium ex vivo is a novel and relatively untested application.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female patients diagnosed with ovarian endometrioma who undergo surgical treatment (cystectomy or adnexectomy) at Kanazawa University Hospital between January 1, 2025, and March 31, 2027. * Written informed consent obtained prior to study participation. * Age ≥ 20 years at the time of consent. * For patients with previously stored endometrioma specimens under a broad consent, additional written consent for participation in this study will be obtained. Exclusion Criteria: * Patients with suspected malignancy based on preoperative imaging. * Patients judged by the attending physician to be unsuitable for participation in this study for any reason.
Where it's running
-
Kanazawa University Hospital
Kanazawa, Ishikawa-ken, Japan Recruiting
Study contacts
- Principal investigator: Kaoru Abiko, MD, PhD — Kanazawa University, Department of Obstetrics and Gynecology
- Study coordinator: Tatsuhito Kanda, MD, PhD
- Email: tkanda@staff.kanazawa-u.ac.jp
- Phone: +81-76-265-2425
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Depth of Argon Beam Coagulation in Ovarian Endometriomas
This study tests how deeply Argon Beam Coagulation affects ovarian tissue during laparoscopic surgery for ovarian endometriomas in women aged 18-40.
-
Comparing different techniques to treat endometriosis
This study is testing different methods to treat endometriosis, like laser and heat techniques, to see which one works best for relieving pain in women who are already having surgery for the condition.
-
Postoperative Pain Trajectories After Endometriosis Surgery
This study tests how pain changes after endometriosis surgery and whether perioperative pain testing can predict who will have ongoing pain.
-
Imaging endometriosis with a special PET tracer in adult women
This study tests whether a PET/CT scan using [18F]AlF-FAPI-74 can help detect endometriosis lesions in women who are planning laparoscopy.
-
Fiber supplement for digestive symptoms in endometriosis
A fiber-based supplement is being tested to see if it is safe and helps with gut and vaginal microbiomes and digestive symptoms in women with endometriosis.
-
Stellate ganglion block and dexmedetomidine for better sleep after gynecologic laparoscopy
The study tests whether giving a preoperative stellate ganglion block plus intraoperative dexmedetomidine improves sleep after laparoscopic gynecologic surgery in women.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.