Non-hormonal nanodrug targeting endometriosis lesions
Official title: Development of anti-inflammatory nanodrug for endometriosis treatment
Funded at Michigan State University · NIH-11365825 · Data updated 2026-11-12
A tiny nanoparticle treatment using cerium oxide bound to albumin aims to shrink endometriosis lesions and ease pain without hormonal therapy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | September 30, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $628,601 |
| NIH project number | 5R01HD108895-05 |
| Project ID | NIH-11365825 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with endometriosis, especially those seeking non-hormonal treatment options.
✕Less likely to help
Patients with conditions unrelated to endometriosis or those unable to access nanoparticle-based therapies may not benefit.
What this research studies
This project develops a targeted, non-hormonal nanodrug designed to accumulate in endometriosis lesions and reduce inflammation driven by pSTAT3. The approach uses albumin-coated nanoceria with a fluorescent dye to track delivery and ensure safety. Researchers will test the therapy in preclinical models to see if it can lower lesion numbers and inflammation while minimizing side effects. If successful, this could lead to a new option for people with endometriosis who cannot or prefer not to use hormonal treatments.
Why it matters
Potential benefit: If successful, the treatment could reduce endometriosis lesions and pain with fewer hormonal side effects.
How similar studies have gone: Preclinical studies have shown that nanoceria can reduce endometriotic lesions in mouse models, supporting further development.
Where this research is happening
-
Michigan State University
East Lansing, United States Active
Researchers
- Principal investigator: Kim, Taeho — Michigan State University
- Study coordinator: Kim, Taeho
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.