Analyzing salivary microRNA in endometriosis patients and their response to progestin therapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the salivary microRNA profiles of patients diagnosed with endometriosis to determine differences between those who respond to progestin therapy and those who do not. Ninety patients attending the Chronic Pelvic Pain Clinic will provide saliva samples before starting treatment with 2 mg dienogest. After four months of therapy, the researchers will evaluate the treatment response and analyze the salivary miRNA signatures to identify potential biomarkers for therapy response. The goal is to enhance non-invasive diagnostic tools for early identification and treatment of endometriosis.

Why it matters

Who can join: the full rules

INCLUSION CRITERIA

* Age \> 18 years
* Fertile age
* Clinical-ultrasound diagnosis or histological diagnosis of endometriosis
* Informed consent

EXCLUSION CRITERIA

* Pregnancy
* Pre-menarcheal or post-menopausal status
* Chronic pelvic pain syndrome with or without central sensitization assessed with the Central Sensitization Inventory Test (CSI)
* Neoplasia, diabetes, BMI \> 30 kg/m2, coagulopathies, autoimmune diseases, or other conditions that may affect salivary miRNA measurement
* Currently undergoing progestin therapy

Where it's running

• University of Udine
  Udine, Ud, Italy Recruiting

Study contacts

• Study coordinator: Matilde Degano, dr
• Email: matildedegano@rocketmail.com
• Phone: 3206173076

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Comparing different techniques to treat endometriosis

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• Postoperative Pain Trajectories After Endometriosis Surgery

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• Imaging endometriosis with a special PET tracer in adult women

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  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT07876648

• Fiber supplement for digestive symptoms in endometriosis

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  Recruiting LOAM Science · San Francisco, California · NCT07875062

• Stellate ganglion block and dexmedetomidine for better sleep after gynecologic laparoscopy

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• Atypical Endometriosis: Histology, Immunophenotype and Molecular Features

  Researchers will look at how endometriotic tissue that looks atypical under the microscope relates to clinical features and ultrasound findings to better separate benign from potentially atypical lesions.

  Recruiting Casa di Cura Dott. Pederzoli · Peschiera del Garda, Verona · NCT07816133

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.