Investigating blood and tissue markers for diagnosing endometriosis
Official title: Blood and Tissue Markers for Improving Diagnosis and Prognosis of Endometriosis. a Prospective Multicenter Nationwide Study. (ENDOBIO)
Run by Region Stockholm · NCT05339451 · Data updated 2026-11-12
This study is trying to find blood and tissue markers that can help doctors diagnose endometriosis earlier and more accurately in women who are having surgery for suspected cases.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 345 (estimated) |
| Sponsor | Region Stockholm Government |
| Locations | 3 sites (Stockholm, Huddinge and 2 other locations) |
| Status | Recruiting |
| Started | May 4, 2023 |
| Main results expected | December 31, 2025 |
| Study ends | December 31, 2026 |
| Registry record updated | February 24, 2025 |
| Trial ID | NCT05339451 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women aged 18-45 who are undergoing surgery for suspected endometriosis or other benign gynecological issues.
✕Probably not a fit
Patients who are postmenopausal, have a BMI over 40, or have certain other medical conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to identify and validate biomarkers associated with endometriosis to improve diagnosis and prognosis. It will involve women of reproductive age who are undergoing laparoscopic surgery for suspected endometriosis or other benign gynecological conditions. The study will analyze blood and tissue samples to correlate these biomarkers with clinical manifestations, relapse rates, and fertility outcomes. The goal is to develop a laboratory test that can facilitate earlier and more accurate diagnosis of endometriosis.
Why it matters
Potential benefit: If successful, this study could lead to earlier diagnosis and better management of endometriosis, reducing the time patients suffer before receiving appropriate care.
How similar studies have gone: While there have been studies exploring biomarkers in endometriosis, this specific approach to validate them for diagnosis and prognosis is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
IInclusion Criteria: * women of reproductive age (18-45) who are operated because of suspected endometriosis (dysmenorrhea, dyspareunia, infertility, etc.) (patient group) * women of reproductive age (18-45) who are operated for other benign gynecological causes with laparoscopy (ovarian cysts, sterilization, fibroids, etc.) and are found without macroscopic endometriosis perioperatively and confirmed with blind biopsies (control group * talk swedish or english in order to complete questionnaires and give informed consent for their participation in the study. Exclusion Criteria: * BMI\> 40 * postmenopausal women * premature ovarian failure * pelvic inflammatory disease (PID) * current or previous malignancy * pregnancy and 6 months postpartum * corticosteroids in the last 3 months * pituitary, kidney, liver, adrenal disease * endometrial hyperplasia or endometrial polyp * cardiovascular or systemic inflammatory diseases.
Where it's running
-
Karolinska Universitetssjukhus Huddinge
Stockholm, Huddinge, Sweden Recruiting -
Södersjukhuset Kvinnokliniken
Stockholm, Stockholm County, Sweden Recruiting -
Akademiska Uppsala
Uppsala, Sweden Not yet recruiting
Study contacts
- Principal investigator: Kenny Rodriguez-Wallberg, Professor — Karolinska Institutet
- Study coordinator: Anastasia Drakou, MSc
- Email: anastasia.drakou@regionstockholm.se
- Phone: 0046 735500118
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Comparing different techniques to treat endometriosis
This study is testing different methods to treat endometriosis, like laser and heat techniques, to see which one works best for relieving pain in women who are already having surgery for the condition.
-
Postoperative Pain Trajectories After Endometriosis Surgery
This study tests how pain changes after endometriosis surgery and whether perioperative pain testing can predict who will have ongoing pain.
-
Imaging endometriosis with a special PET tracer in adult women
This study tests whether a PET/CT scan using [18F]AlF-FAPI-74 can help detect endometriosis lesions in women who are planning laparoscopy.
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Fiber supplement for digestive symptoms in endometriosis
A fiber-based supplement is being tested to see if it is safe and helps with gut and vaginal microbiomes and digestive symptoms in women with endometriosis.
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Stellate ganglion block and dexmedetomidine for better sleep after gynecologic laparoscopy
The study tests whether giving a preoperative stellate ganglion block plus intraoperative dexmedetomidine improves sleep after laparoscopic gynecologic surgery in women.
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Atypical Endometriosis: Histology, Immunophenotype and Molecular Features
Researchers will look at how endometriotic tissue that looks atypical under the microscope relates to clinical features and ultrasound findings to better separate benign from potentially atypical lesions.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.