Improving fertility in women with endometriosis through diet during IVF
Official title: Randomized Controlled Study on the Effect of a DietAry interveNtion in Ameliorating fertiliTy Parameters in Women With endomEtriosis Undergoing IVF (The DANTE Study)
Run by Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · NCT06885125 · Data updated 2026-11-12
This study is testing if following an anti-inflammatory diet for 12 weeks can help women with endometriosis have better fertility results during IVF.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 39 Years |
| Sex | Women only |
| Enrollment | 438 (estimated) |
| Sponsor | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico Academic / other |
| Locations | 1 site (Milan) |
| Status | Recruiting |
| Started | March 24, 2025 |
| Main results expected | June 30, 2029 |
| Study ends | December 31, 2029 |
| Registry record updated | November 2, 2026 |
| Trial ID | NCT06885125 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women under 40 years old with a diagnosis of endometriosis and a history of infertility for more than 12 months.
✕Probably not a fit
Patients with severe male factor infertility or contraindications to pregnancy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized controlled trial aims to evaluate the effectiveness of a 12-week anti-inflammatory diet on fertility outcomes in women with endometriosis who are undergoing In Vitro Fertilization (IVF). Participants will be divided into two groups: one receiving standard IVF protocols and the other following the anti-inflammatory diet in addition to the IVF protocol. The study will assess primary outcomes such as the rate of inadequate ovarian response and secondary outcomes including embryo quality, pregnancy rates, inflammation markers, and quality of life. Biological samples will be collected to analyze potential changes in inflammation and hormonal levels.
Why it matters
Potential benefit: If successful, this intervention could enhance fertility outcomes for women with endometriosis undergoing IVF.
How similar studies have gone: While dietary interventions in fertility are being explored, this specific approach combining an anti-inflammatory diet with IVF is relatively novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \< 40 years * Pregnancy seeking for more than 12 months * Regular menstrual cycle, i.e. mean cycle interval between 21 and 35 days * Ultrasonographic diagnosis of ovarian endometriomas or deep peritoneal endometriosis. * Antral Follicle Counts (AFC) ≥ 5 (no other cause of reduced ovarian reserve). * Absence of ureteral stenosis or intestinal subocclusive symptoms Exclusion Criteria: * Contraindication to pregnancy * Hydrosalpinx * Endometriomas with a mean diameter \> 4 cm * Submucosal fibroids or large intramural or subserosal fibroids (≥ 5 cm). * Doubtful sonographic findings that do not allow to reliably rule out malignancy. * severe male factor (\<1 million sperm/ml)
Where it's running
-
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Milan, Italy Recruiting
Study contacts
- Study coordinator: Paola Vigano', PhD
- Email: paola.vigano@policlinico.mi.it
- Phone: +390255034302
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.