Cell enzymes (kinases) as new treatment targets for endometriosis
Kinases as Therapeutic Targets for Endometriosis
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-11319871
The team is seeing whether blocking certain cell enzymes called kinases could lead to new medicines for people with endometriosis.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11319871 on ClinicalTrials.gov |
What this research studies
If you have endometriosis, researchers will use tissue and cells taken from women to study enzymes called kinases that are more active in endometriosis lesions. They will turn off those enzymes in lab-grown cells and organoids and test existing small drugs that target them. The team will also search for new drug-like molecules using a DNA-encoded chemistry method and then refine promising compounds in lab and animal tests. This work aims to identify drug candidates that could move into future clinical trials.
Who could benefit from this research
Good fit: Ideal candidates are people with diagnosed endometriosis who might donate tissue during surgery or join future clinical trials of new drug candidates.
Not a fit: People without endometriosis or those seeking immediate symptom relief should not expect direct benefit from this lab-focused discovery work.
Why it matters
Potential benefit: If successful, this could lead to new targeted drugs that reduce endometriosis lesions and symptoms like pelvic pain.
How similar studies have performed: Kinase-blocking drugs have helped other diseases and early lab studies support kinases as promising targets in endometriosis, but identifying new inhibitors with DEC-Tec for this condition is relatively new.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MATZUK, MARTIN M. — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: MATZUK, MARTIN M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.