Understanding how the uterus absorbs fluid during early pregnancy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the mechanisms of uterine fluid absorption during early pregnancy, focusing on women with and without endometriosis. It includes healthy women aged 18 to 45, as well as those diagnosed with endometriosis or infertility. The study will analyze various factors, including menstrual cycle regularity and endometrial thickness, to understand the physiological processes involved. Participants will be recruited from multiple locations, including Johns Hopkins Hospital and Rutgers University.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Subject must be a healthy woman between the ages of 18 and 45 years.
2. Women with diagnosed endometriosis or infertility (cases).
3. Women without a diagnosis of endometriosis or infertility (controls).
4. Subject must have regular menstrual cycles.
5. Subject must have a body mass index (BMI) between 18 and 40.
6. Subject must be or have been sexually active or have had a previous vaginal exam that used a speculum.
7. Subject must be able to understand and provide consent to procedures and use/disclosure of protected health information.
8. No history of Chlamydia trachomatis, Mycoplasma genitalium, Neisseria gonorrhoeae, hepatitis B, and HIV.
9. For IVF study subjects, a minimum endometrial thickness of 7mm at the time of sample collection.

Exclusion Criteria:

1. Pregnant women.
2. Study subjects with endometrial cancer.
3. Study subjects with a history of endometrial ablation.
4. Study subjects with undiagnosed uterine bleeding.
5. Women with reproductive diseases that affect the endometrium (such as fibroids or uterine polyps that distort endometrial cavity).
6. Study subjects with an intrauterine device (IUD).

Where it's running

• Johns Hopkins Hospital
  Baltimore, Maryland, United States Recruiting
• University of Georgia
  Athens, Georgia, United States Not yet recruiting
• Rutgers University
  Piscataway, New Jersey, United States Active not recruiting

Study contacts

• Study coordinator: James Segars, MD
• Email: jsegars2@jhmi.edu
• Phone: 410-614-2000

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Imaging endometriosis with a special PET tracer in adult women

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• Fiber supplement for digestive symptoms in endometriosis

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  Recruiting LOAM Science · San Francisco, California · NCT07875062

• Stellate ganglion block and dexmedetomidine for better sleep after gynecologic laparoscopy

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• Atypical Endometriosis: Histology, Immunophenotype and Molecular Features

  Researchers will look at how endometriotic tissue that looks atypical under the microscope relates to clinical features and ultrasound findings to better separate benign from potentially atypical lesions.

  Recruiting Casa di Cura Dott. Pederzoli · Peschiera del Garda, Verona · NCT07816133

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.