Biomarkers for Endometriosis: SNCG and BCL6 in blood and menstrual fluid
Official title: A Prospective, Observational and Multicentric Study to Evaluate the Performance and Clinical Utility of EndoID ELISA Kit to Determine Circulating Synuclein Gamma (SNCG) and B-cell Lymphoma-6 (BCL6) Levels as Potential Biomarkers for Endometriosis"
Run by Trio Fertility · NCT07713797 · Data updated 2026-11-12
This study looks at whether SNCG and BCL6 proteins in blood and menstrual fluid can help diagnose endometriosis without invasive surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 100 (estimated) |
| Sponsor | Trio Fertility Academic / other |
| Locations | 1 site (Toronto, Ontario) |
| Status | Recruiting |
| Started | January 16, 2026 |
| Main results expected | January 1, 2027 |
| Study ends | September 1, 2027 |
| Registry record updated | August 3, 2026 |
| Trial ID | NCT07713797 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women aged 18–45 with active endometriosis diagnosed by ultrasound/MRI/laparoscopy, plus an age-matched control group without endometriosis.
✕Probably not a fit
The biomarkers may not distinguish endometriosis from other conditions or may not be detectable in all patients.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates whether measurable proteins SNCG and BCL6 in blood and menstrual fluid correlate with endometriosis. Participants include women aged 18 to 45 with active endometriosis diagnosed by imaging or laparoscopy, and a control group without endometriosis. The study aims to identify non-invasive biomarkers that could aid diagnosis and monitoring. Blood and menstrual samples will be analyzed for levels of SNCG and BCL6 and compared between groups. No intervention beyond sample collection is described; findings could inform future diagnostic approaches.
Why it matters
Potential benefit: If successful, non-invasive tests could reduce the need for surgical diagnosis and enable earlier management of endometriosis.
How similar studies have gone: Biomarker research for endometriosis has shown promise with various markers, but no widely validated non-invasive test yet; this study contributes additional data on SNCG and BCL6.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria for Endometriosis Group: * Women of reproductive age group (18Y-45Y). * Women with active endometriosis diagnosed by ultrasound/MRI/laparoscopy. Exclusion Criteria for Endometriosis Group: * Women \<18Y and \>45Y. * Women with endometriosis during stimulation with gonadotropins. * Current or prior history of uterine, ovarian, colon, pancreatic, breast or any other type of cancer. * Any prior history of chronic illness. * Pregnant women. Inclusion Criteria for Control Group: * Women of reproductive age group (18Y-45Y). * Women without endometriosis and any other gynaecological problem. Exclusion Criteria for Endometriosis Group: * Women \<18Y and \>45Y * Prior history of any disease including cancer or chronic illness. * Pregnant women.
Where it's running
-
Trio Fertility
Toronto, Ontario, Canada Recruiting
Study contacts
- Study coordinator: Yasaman Sadeghi, M.Sc.
- Email: yasamans@triofertility.com
- Phone: 4165060804
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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This study is testing different methods to treat endometriosis, like laser and heat techniques, to see which one works best for relieving pain in women who are already having surgery for the condition.
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Imaging endometriosis with a special PET tracer in adult women
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A fiber-based supplement is being tested to see if it is safe and helps with gut and vaginal microbiomes and digestive symptoms in women with endometriosis.
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Stellate ganglion block and dexmedetomidine for better sleep after gynecologic laparoscopy
The study tests whether giving a preoperative stellate ganglion block plus intraoperative dexmedetomidine improves sleep after laparoscopic gynecologic surgery in women.
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Atypical Endometriosis: Histology, Immunophenotype and Molecular Features
Researchers will look at how endometriotic tissue that looks atypical under the microscope relates to clinical features and ultrasound findings to better separate benign from potentially atypical lesions.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.