Creating a tissue model to enhance care for endometriosis
Official title: Developing a Complex ex Vivo Endometrial Tissue Model Based on Patient Biopsies to Assess and Optimise the Response to Current and Potential Treatments for Endometriosis
Run by Hospices Civils de Lyon · NCT06331676 · Data updated 2026-11-12
This study is trying to create a new tissue model to help doctors better understand endometriosis and see how different hormonal treatments might work for patients.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 50 Years |
| Sex | Women only |
| Enrollment | 90 (estimated) |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 2 sites (Bron and 1 other locations) |
| Status | Recruiting |
| Started | June 21, 2024 |
| Main results expected | March 21, 2028 |
| Study ends | March 21, 2028 |
| Registry record updated | January 30, 2026 |
| Trial ID | NCT06331676 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are women aged 18 to 50 who have been diagnosed with endometriosis or require surgical intervention for benign gynecological conditions.
✕Probably not a fit
Patients who are pregnant, breastfeeding, or have a history of certain cancers may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project aims to develop a complex ex vivo model of endometrial tissue that mimics the human endometrium using advanced tissue bioengineering techniques. By doing so, the study seeks to improve the understanding of endometriosis and the mechanisms of hormonal treatments. The model will facilitate pre-clinical evaluations to predict individual responses to various hormonal therapies, ultimately optimizing treatment choices for patients. This innovative approach addresses the current gaps in research related to endometriosis care.
Why it matters
Potential benefit: If successful, this study could lead to more personalized and effective treatment options for women suffering from endometriosis.
How similar studies have gone: While there have been studies on endometriosis, the specific approach of developing a complex ex vivo tissue model is relatively novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female * People aged between 18 and 50 * Person who has or has had hormonal contraceptive treatment * A person who has given written consent * Person diagnosed with a benign gynaecological pathology not affecting the endometrium and requiring hysterectomy, hysteroscopy or laparoscopy or with a diagnosis of endometriosis and requiring laparoscopy or hysterectomy * Person affiliated to the french social security Exclusion Criteria: * Pregnant at the time of sampling or within 3 months prior to sampling * Breast-feeding women * Women undergoing physiological menopause * Anyone who has received hormonal treatment with hormones other than steroids in the three months prior to sampling * Anyone with a non-hormonal contraceptive intrauterine device (copper coil) * Anyone with a personal history of cancer of the breast, ovary, endometrium or cervix * People with Lynch syndrome * Persons under legal protection (guardianship, curatorship) * Persons deprived of their liberty by judicial or administrative decision * Persons with a body mass index (BMI) of less than 18.5 or more than 30
Where it's running
-
Hôpital Femme Mère Enfant / GHE
Bron, France Recruiting -
Hôpital de la Croix-Rousse / GHN
Lyon, France Recruiting
Study contacts
- Study coordinator: Charles-André PHILIP, M.D., PhD
- Email: charles-andre.philip01@chu-lyon.fr
- Phone: 04 27 85 51 70
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Comparing different techniques to treat endometriosis
This study is testing different methods to treat endometriosis, like laser and heat techniques, to see which one works best for relieving pain in women who are already having surgery for the condition.
-
Postoperative Pain Trajectories After Endometriosis Surgery
This study tests how pain changes after endometriosis surgery and whether perioperative pain testing can predict who will have ongoing pain.
-
Imaging endometriosis with a special PET tracer in adult women
This study tests whether a PET/CT scan using [18F]AlF-FAPI-74 can help detect endometriosis lesions in women who are planning laparoscopy.
-
Fiber supplement for digestive symptoms in endometriosis
A fiber-based supplement is being tested to see if it is safe and helps with gut and vaginal microbiomes and digestive symptoms in women with endometriosis.
-
Stellate ganglion block and dexmedetomidine for better sleep after gynecologic laparoscopy
The study tests whether giving a preoperative stellate ganglion block plus intraoperative dexmedetomidine improves sleep after laparoscopic gynecologic surgery in women.
-
Atypical Endometriosis: Histology, Immunophenotype and Molecular Features
Researchers will look at how endometriotic tissue that looks atypical under the microscope relates to clinical features and ultrasound findings to better separate benign from potentially atypical lesions.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.