Creating a tissue model to enhance care for endometriosis
Developing a Complex ex Vivo Endometrial Tissue Model Based on Patient Biopsies to Assess and Optimise the Response to Current and Potential Treatments for Endometriosis
NA · Hospices Civils de Lyon · NCT06331676
This study is trying to create a new tissue model to help doctors better understand endometriosis and see how different hormonal treatments might work for patients.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | Female |
| Sponsor | Hospices Civils de Lyon (other) |
| Locations | 2 sites (Bron and 1 other locations) |
| Trial ID | NCT06331676 on ClinicalTrials.gov |
What this trial studies
This project aims to develop a complex ex vivo model of endometrial tissue that mimics the human endometrium using advanced tissue bioengineering techniques. By doing so, the study seeks to improve the understanding of endometriosis and the mechanisms of hormonal treatments. The model will facilitate pre-clinical evaluations to predict individual responses to various hormonal therapies, ultimately optimizing treatment choices for patients. This innovative approach addresses the current gaps in research related to endometriosis care.
Who should consider this trial
Good fit: Ideal candidates for this study are women aged 18 to 50 who have been diagnosed with endometriosis or require surgical intervention for benign gynecological conditions.
Not a fit: Patients who are pregnant, breastfeeding, or have a history of certain cancers may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more personalized and effective treatment options for women suffering from endometriosis.
How similar studies have performed: While there have been studies on endometriosis, the specific approach of developing a complex ex vivo tissue model is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female * People aged between 18 and 50 * Person who has or has had hormonal contraceptive treatment * A person who has given written consent * Person diagnosed with a benign gynaecological pathology not affecting the endometrium and requiring hysterectomy, hysteroscopy or laparoscopy or with a diagnosis of endometriosis and requiring laparoscopy or hysterectomy * Person affiliated to the french social security Exclusion Criteria: * Pregnant at the time of sampling or within 3 months prior to sampling * Breast-feeding women * Women undergoing physiological menopause * Anyone who has received hormonal treatment with hormones other than steroids in the three months prior to sampling * Anyone with a non-hormonal contraceptive intrauterine device (copper coil) * Anyone with a personal history of cancer of the breast, ovary, endometrium or cervix * People with Lynch syndrome * Persons under legal protection (guardianship, curatorship) * Persons deprived of their liberty by judicial or administrative decision * Persons with a body mass index (BMI) of less than 18.5 or more than 30
Where this trial is running
Bron and 1 other locations
- Hôpital Femme Mère Enfant / GHE — Bron, France (RECRUITING)
- Hôpital de la Croix-Rousse / GHN — Lyon, France (RECRUITING)
Study contacts
- Study coordinator: Charles-André PHILIP, M.D., PhD
- Email: charles-andre.philip01@chu-lyon.fr
- Phone: 04 27 85 51 70
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Endometriosis, endometriosis, tissue bioengineering, hormonal therapies