Using GnRH agonist to improve pregnancy rates in women with endometriosis or adenomyosis before embryo transfer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of administering GnRH agonists to women with endometriosis and/or adenomyosis prior to frozen embryo transfer. The study compares the outcomes of patients receiving one or two doses of GnRH agonist alongside standard hormonal support against those receiving hormonal support alone. The aim is to reduce pro-inflammatory markers in the endometrium, potentially enhancing implantation rates and improving fertility outcomes for these patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women aged 18 to 36 years (women ≥18 years to \<36 years) with endometriosis and / or adenomyosis
* Having benefited from In vitro fertilisation /intracytoplasmic micro-injection with freeze all and for whom the frozen embryon transfer of a blastocyst is planned
* A normal uterine cavity
* An MRI showing endometriosis and / or adenomyosis during the inclusion visit
* Having signed a consent form
* Being affiliated to a Health Insurance Plan.

Exclusion Criteria:

* Patient aged \<18 years and ≥ 36 years
* BMI\> 35
* History of implantation failures (≥ 2)
* Endometrial alterations: synechiae, polyps, myomas, hyperplasia, hematometra
* known hydrosalpinx uni or bilateral
* MRI showing no endometriosis or adenomyosis
* Hypersensitivity to GnRH, GnRH analogues, or any of the excipients of Decapeptyl 3 mg
* Known hypersensitivity to estradiol
* Known hypersensitivity to progesterone
* Known hypersensitivity to acetylsalicylic acid or other nonsteroidal anti-inflammatory drugs
* Known hypersensitivity to folic acid
* Known hypersensitivity to cefixime or an antibiotic in the cephalosporin group
* Known hypersensitivity to levofloxacin or any other quinolone
* History of tendinopathies related to the administration of fluoroquinolones
* Epilepsy
* Hypersensitivity to contrast agents for MRI
* Known or suspected breast cancer or history of breast cancer
* Known or suspected genital tract cancer or history of genital cancer
* known or suspected estrogen-dependent malignant neoplasms
* Undiagnosed genital haemorrhage
* Untreated endometrial hyperplasia
* History of idiopathic venous thrombo-embolic accident or evolving venous thrombo-embolic event (deep vein thrombosis, pulmonary embolism)
* Recent or evolving arterial thromboembolic stroke (eg angina, myocardial infarction)
* Acute liver disease or history of liver disease, until hepatic tests are normalized
* Severe renal insufficiency
* Severe, uncontrolled heart failure
* Evolutionary gastroduodenal ulcer
* History of asthma caused by the administration of salicylates or substances of similar activity, especially nonsteroidal anti-inflammatory drugs
* GnRH Agonist Decapeptyl administered within 6 months prior to transfer
* To be deprived of liberty or under guardianship
* Pregnancy and breast feeding.

Where it's running

• Hopital Foch
  Suresnes, France Recruiting

Study contacts

• Study coordinator: Elisabeth Hulier-Ammar, Dr
• Email: e.hulier-ammar@hopital-foch.com
• Phone: 0033146251175

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.