Deep posterior endometriosis surgery and ovarian reserve

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Women aged 18–39 with suspected or confirmed severe deep posterior pelvic endometriosis and no ovarian endometriomas will undergo planned surgical resection. Ovarian reserve will be measured before and after surgery using anti‑Müllerian hormone (AMH) assays and pelvic ultrasound including antral follicle count, and participants will complete symptom and reproductive history questionnaires. The study excludes patients with prior surgery for severe deep endometriosis, significant preoperative ovarian insufficiency, recent GnRH agonist use, BMI >35, or menopause. The trial is conducted at Clinique la croix du sud in Quint‑Fonsegrives and is sponsored by Ramsay Générale de Santé.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female, aged 18 to 39 years old;
* Suspected severe deep posterior pelvic endometriosis on reference pelvic MRI (ovarian kissing, obliteration of the pouch of Douglas) with concordant clinical examination, or confirmed severe deep posterior pelvic endometriosis during exploratory laparoscopy;
* Patient affiliated with or covered by a social security plan;
* Patient having been informed and having given her free, informed, and written consent

Exclusion Criteria:

* Presence of ovarian involvement defined by the presence of at least one endometrioma \>5 mm;
* History of surgery for severe deep endometriosis;
* Severe preoperative premature ovarian insufficiency (defined by AMH \<1ng/mL and antral follicle count \<8);
* Concurrent use of GnRH agonist therapy at or within the preceding 3 months of enrollment;
* BMI \>35 kg/m²;
* Menopausal status;
* Patient participating in another trial with an exclusion period that has not yet expired at the time of screening;
* Protected patient: adult under guardianship, curatorship, or other legal protection, deprived of liberty by judicial or administrative decision;
* Pregnant, breastfeeding, or postpartum woman.

Where it's running

• Clinique la croix du sud
  Quint-Fonsegrives, France Recruiting

Study contacts

• Study coordinator: Jean-François Oudet
• Email: jf.oudet@ecten.eu
• Phone: 0033683346567

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.