Dietary guidance and probiotics for pelvic pain in women with endometriosis and IBS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants with endometriosis and coexisting irritable bowel syndrome will be randomized to different intervention arms that include dietary guidance and use of Lactobacillus probiotics. The study will follow participants over a treatment period to record changes in chronic pelvic pain and bowel symptoms. Investigators will compare symptom scores between the groups to determine whether non‑pharmacological approaches relieve pain and improve bowel habits. The trial aims to clarify the role of diet and gut microbiota modulation in managing these overlapping conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Women between 18 and 50 years of age who wish to participate in the clinical trial;
2. Willingness to voluntarily participate in the study and accept randomization to any of the three treatment arms;
3. Participating exclusively in this clinical trial during the study period;
4. Signing the Informed Consent Form (ICF) approved by the Research Ethics Committee (CEP) and CONEP

Exclusion Criteria:

1. Chronic, severe, or uncompensated clinical conditions, such as: malnutrition (BMI \<18); insulin-dependent diabetes (types 1 or 2); uncontrolled hypertension; lung disease such as asthma or other chronic obstructive pulmonary disease; hematologic and liver diseases; advanced-stage chronic kidney disease (grades 3, 4, and 5); metabolic disorders; and immunosuppression;
2. Clinical conditions of the gastrointestinal tract that cause IBS-like symptoms, such as: inflammatory bowel disease (Chron's disease, ulcerative colitis), microscopic colitis, celiac disease, and lactose intolerance;
3. Endometriosis requiring surgical treatment during the study period;
4. Severe eating disorders, such as: bulimia, anorexia nervosa, and binge-eating disorder;
5. Chronic use of any medication with potential interaction with probiotics, the intestinal microbiota, or the natural progression of the disease in the last 6 months (such as probiotics, antibiotics, antifungals, antihistamines, digestive medications, or treatments for constipation or diarrhea);
6. Patients who already consume healthy foods or are on a restrictive diet more than four days a week, which may affect the evaluation results;
7. Patients whose stool protopastological examination is altered;
8. Inability to use oral medication;
9. Pregnancy or lactation;
10. History of alcohol or drug dependence;
11. Smoking in the last three years;
12. Inability to cooperate with investigators due to cognitive impairment or mental state.

Where it's running

• Letícia Ferracini Lenharo Hayashi
  Catanduva, São Paulo, Brazil Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Postoperative Pain Trajectories After Endometriosis Surgery

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• Imaging endometriosis with a special PET tracer in adult women

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• Fiber supplement for digestive symptoms in endometriosis

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  Recruiting LOAM Science · San Francisco, California · NCT07875062

• Stellate ganglion block and dexmedetomidine for better sleep after gynecologic laparoscopy

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• Atypical Endometriosis: Histology, Immunophenotype and Molecular Features

  Researchers will look at how endometriotic tissue that looks atypical under the microscope relates to clinical features and ultrasound findings to better separate benign from potentially atypical lesions.

  Recruiting Casa di Cura Dott. Pederzoli · Peschiera del Garda, Verona · NCT07816133

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.